Department of Medical Physiology
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Coagulation-associated enhancement of fibrinolytic activity via a neutralization of PAI-1 activity.
Seminars in thrombosis and hemostasis , 2000 | Pubmed ID: 10805280
[Regulatory mechanism of fibrinolysis system by thrombin activatable fibrinolysis inhibitor (TAFI)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica Nov, 2000 | Pubmed ID: 11215380
The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis Cleaves and inactivates plasminogen activator inhibitor type 1.
The Journal of biological chemistry Jul, 2001 | Pubmed ID: 11325965
Enhanced secretion of tissue plasminogen activator by simultaneous use of retinoic acid and ascorbic acid from tissue cultured gastroepiploic artery.
Life sciences Feb, 2002 | Pubmed ID: 11883720
Tissue-type plasminogen activator has paradoxical roles in focal cerebral ischemic injury by thrombotic middle cerebral artery occlusion with mild or severe photochemical damage in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jun, 2002 | Pubmed ID: 12045662
Decoding of short-lived Ca2+ influx signals into long term substrate phosphorylation through activation of two distinct classes of protein kinase C.
The Journal of biological chemistry Mar, 2003 | Pubmed ID: 12514176
Dietary supplementation with fermented soybeans suppresses intimal thickening.
Nutrition (Burbank, Los Angeles County, Calif.) Mar, 2003 | Pubmed ID: 12620531
Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery.
Life sciences Jul, 2003 | Pubmed ID: 12850244
Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice.
Blood Apr, 2004 | Pubmed ID: 14630814
Activated protein C attenuates coagulation-associated over-expression of fibrinolytic activity by suppressing the thrombin-dependent inactivation of PAI-1.
Journal of thrombosis and haemostasis : JTH Dec, 2003 | Pubmed ID: 14675098
Sexual dimorphism in endotoxin susceptibility after partial hepatectomy in rats.
Journal of hepatology May, 2005 | Pubmed ID: 15826722
Plasminogen activator inhibitor type 1 promotes fibrosarcoma cell migration by modifying cellular attachment to vitronectin via alpha(v)beta(5) integrin.
Seminars in thrombosis and hemostasis Jun, 2005 | Pubmed ID: 16052409
Protein S attenuates the invasive potential of THP-1 cells by interfering with plasminogen binding on cell surface via a protein C-independent mechanism.
FEBS letters Nov, 2005 | Pubmed ID: 16229836
Less pronounced enhancement of thrombin-dependent inactivation of plasminogen activator inhibitor type 1 by low molecular weight heparin compared with unfractionated heparin.
Thrombosis and haemostasis Apr, 2006 | Pubmed ID: 16601834
Nafamostat attenuated the impairment of fibrinolysis in animal sepsis model by suppressing the increase of plasminogen activator inhibitor type 1.
The Journal of trauma Apr, 2006 | Pubmed ID: 16612309
Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells.
The Journal of biological chemistry Sep, 2006 | Pubmed ID: 16870611
Intraperitoneal infusion of recombinant plasminogen activator inhibitor type 2 induced apoptosis in implanted human colon cancer and inhibited its growth and liver metastasis.
Anticancer research Mar-Apr, 2008 | Pubmed ID: 18507009
Real-time analysis of platelet aggregation and procoagulant activity during thrombus formation in vivo.
Pflugers Archiv : European journal of physiology Sep, 2008 | Pubmed ID: 18553102
Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells.
Blood Jan, 2009 | Pubmed ID: 18922856
Involvement of platelet activation by P2Y12 receptor in the development of transplant arteriosclerosis in mice.
Transplantation Mar, 2009 | Pubmed ID: 19295309
Inactivation of plasminogen activator inhibitor type 1 by activated factor XII plays a role in the enhancement of fibrinolysis by contact factors in-vitro.
Life sciences Jul, 2009 | Pubmed ID: 19500599
A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy.
Pflügers Archiv : European journal of physiology Nov, 2009 | Pubmed ID: 19680684
In vivo imaging analysis of the interaction between unusually large von Willebrand factor multimers and platelets on the surface of vascular wall.
Pflugers Archiv : European journal of physiology Jun, 2011 | Pubmed ID: 21494805
Novel situations of endothelial injury in stroke--mechanisms of stroke and strategy of drug development: novel mechanism of the expression and amplification of cell surface-associated fibrinolytic activity demonstrated by real-time imaging analysis.
Journal of pharmacological sciences , 2011 | Pubmed ID: 21498960
Surface-retained tPA is essential for effective fibrinolysis on vascular endothelial cells.
Blood Sep, 2011 | Pubmed ID: 21791417
[Parameters related to fibrinolysis and their meanings].
Rinsho byori. The Japanese journal of clinical pathology Jul, 2011 | Pubmed ID: 21874797
PAI-1, progress in understanding the clinical problem and its aetiology.
British journal of haematology May, 2012 | Pubmed ID: 22360729
Accelerated fibrinolysis and its propagation on vascular endothelial cells by secreted and retained tPA.
Journal of biomedicine & biotechnology , 2012 | Pubmed ID: 23118500
Binding of thrombin-activated platelets to a fibrin scaffold through α(IIb)β₃ evokes phosphatidylserine exposure on their cell surface.
PloS one , 2013 | Pubmed ID: 23383331
TM5275 prolongs secreted tissue plasminogen activator retention and enhances fibrinolysis on vascular endothelial cells.
Thrombosis research Jul, 2013 | Pubmed ID: 23611258
Endogenously generated plasmin at the vascular wall injury site amplifies lysine binding site-dependent plasminogen accumulation in microthrombi.
PloS one , 2015 | Pubmed ID: 25806939
Platelets Regulate the Migration of Keratinocytes via Podoplanin/CLEC-2 Signaling during Cutaneous Wound Healing in Mice.
The American journal of pathology Jan, 2016 | Pubmed ID: 26597882
Characteristic Distribution Pattern of Lysophosphatidylcholine in Fibromuscular Dysplasia-Associated Visceral Artery Aneurysms Compared with Atherosclerotic Visceral Artery Aneurysms.
Journal of atherosclerosis and thrombosis Jun, 2016 | Pubmed ID: 26666464
The preventive effect of fish oil on abdominal aortic aneurysm development.
Bioscience, biotechnology, and biochemistry Jun, 2016 | Pubmed ID: 27022887
[Recent progress and perspectives in the field of fibrinolysis].
[Rinsho ketsueki] The Japanese journal of clinical hematology Mar, 2016 | Pubmed ID: 27076246
Bidirectional functions of thrombin on fibrinolysis: Evidence of thrombin-dependent enhancement of fibrinolysis provided by spontaneous plasma clot lysis.
Thrombosis research Jul, 2016 | Pubmed ID: 27179129
Activities of wild-type and variant tissue-type plasminogen activators retained on vascular endothelial cells.
FEBS open bio May, 2016 | Pubmed ID: 27419052
Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm.
Scientific reports Aug, 2016 | Pubmed ID: 27499372
Plasminogen activator inhibitor type 1 in platelets induces thrombogenicity by increasing thrombolysis resistance under shear stress in an in-vitro flow chamber model.
Thrombosis research Oct, 2016 | Pubmed ID: 27611498
Imaging analyses of coagulation-dependent initiation of fibrinolysis on activated platelets and its modification by thrombin-activatable fibrinolysis inhibitor.
Thrombosis and haemostasis Apr, 2017 | Pubmed ID: 28150854
Mutation in a highly conserved glycine residue in strand 5B of plasminogen activator inhibitor 1 causes polymerisation.
Thrombosis and haemostasis May, 2017 | Pubmed ID: 28229167
Thrombolytic Therapy Targeting Alpha 2-Antiplasmin.
Circulation Mar, 2017 | Pubmed ID: 28289005
Pathological Analysis of the Ruptured Vascular Wall of Hypoperfusion-induced Abdominal Aortic Aneurysm Animal Model.
Journal of oleo science May, 2017 | Pubmed ID: 28381776
Lysophosphatidylcholine Acyltransferase-3 Expression Is Associated with Atherosclerosis Progression.
Journal of vascular research , 2017 | Pubmed ID: 28683445
Hiroki Tanaka1,2,
Naoki Unno2,
Tatsuro Yata2,
Hirona Kugo3,
Nobuhiro Zaima3,
Takeshi Sasaki4,
Tetsumei Urano1
1Department of Medical Physiology, Hamamatsu University School of Medicine,
2Division of Vascular Surgery, Second Department of Surgery, Hamamatsu University School of Medicine,
3Department of Applied Biological Chemistry, Graduate School of Agriculture, Kindai University,
4Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine
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