John P. Lydon

Reproductive functions of progesterone receptors.

Progesterone's role in mammary gland development and tumorigenesis as disclosed by experimental mouse genetics.

A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development.

Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro.

Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development.

Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform.

Progesterone receptors in mammary gland development and tumorigenesis.

Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms.

Progesterone involvement in breast development and tumorigenesis--as revealed by progesterone receptor "knockout" and "knockin" mouse models.

Hormonal defect in maspin heterozygous mice reveals a role of progesterone in pubertal ductal development.

Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis.

Cre-mediated recombination in cell lineages that express the progesterone receptor.

Revealing progesterone's role in uterine and mammary gland biology: insights from the mouse.

Identification of murine uterine genes regulated in a ligand-dependent manner by the progesterone receptor.

Enhanced sexual behaviors and androgen receptor immunoreactivity in the male progesterone receptor knockout mouse.

Generation of a mouse for conditional excision of progesterone receptor.

Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse.

Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus.

Steroid receptor coactivator 2 is essential for progesterone-dependent uterine function and mammary morphogenesis: insights from the mouse--implications for the human.

Targeting iCre expression to murine progesterone receptor cell-lineages using bacterial artificial chromosome transgenesis.

Progesterone-action in the murine uterus and mammary gland requires steroid receptor coactivator 2: relevance to the human.

Bmp2 is critical for the murine uterine decidual response.

The p160 steroid receptor coactivator 2, SRC-2, regulates murine endometrial function and regulates progesterone-independent and -dependent gene expression.

Mouse models of implantation.

COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity.

The pattern of beta-catenin responsiveness within the mammary gland is regulated by progesterone receptor.

A repressive role for prohibitin in estrogen signaling.

Targeting reverse tetracycline-dependent transactivator to murine mammary epithelial cells that express the progesterone receptor.

Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.

Peroxisome proliferator-activated receptor gamma is a target of progesterone regulation in the preovulatory follicles and controls ovulation in mice.

Steroid receptor coactivator 2 is required for female fertility and mammary morphogenesis: insights from the mouse, relevance to the human.

Bone growth and turnover in progesterone receptor knockout mice.

In vivo analysis of progesterone receptor action in the uterus during embryo implantation.

Gap junction communication between uterine stromal cells plays a critical role in pregnancy-associated neovascularization and embryo survival.

Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice.

Transcriptional response of the murine mammary gland to acute progesterone exposure.

The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse.

The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression.

Stromal progesterone receptors mediate induction of Indian Hedgehog (IHH) in uterine epithelium and its downstream targets in uterine stroma.

Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease.

Finally! A model for progesterone receptor action in normal human breast.

Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells.

The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action.

ERBB receptor feedback inhibitor 1 regulation of estrogen receptor activity is critical for uterine implantation in mice.

A mouse model to dissect progesterone signaling in the female reproductive tract and mammary gland.

Ablation of Indian hedgehog in the murine uterus results in decreased cell cycle progression, aberrant epidermal growth factor signaling, and increased estrogen signaling.

Epithelial-stromal interaction and progesterone receptors in the mouse uterus.

Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse.

Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization.

Foxa2 is essential for mouse endometrial gland development and fertility.

Stem cells: Cues from steroid hormones.

Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression.

WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development.

Minireview: steroid receptor coactivator-3: a multifarious coregulator in mammary gland metastasis.

A mouse transgenic approach to induce β-catenin signaling in a temporally controlled manner.

WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse.

Estrogen-regulated prohibitin is required for mouse uterine development and adult function.

The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2.

Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice.

Connective tissue growth factor is required for normal follicle development and ovulation.

From the ranks of mammary progesterone mediators, RANKL takes the spotlight.

Epithelial progesterone receptor exhibits pleiotropic roles in uterine development and function.

CDH1 is essential for endometrial differentiation, gland development, and adult function in the mouse uterus.

NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy.

GATA2 is expressed at critical times in the mouse uterus during pregnancy.

Uterine development and fertility are dependent on gene dosage of the nuclear receptor coregulator REA.

Progesterone receptors: a key for neuroprotection in experimental stroke.

Research resource: Genome-wide profiling of progesterone receptor binding in the mouse uterus.

A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis.

Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability.

Dysregulation of uterine signaling pathways in progesterone receptor-Cre knockout of dicer.

Nuclear receptor coactivator-6 attenuates uterine estrogen sensitivity to permit embryo implantation.

Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression.

Functional role of progestin and the progesterone receptor in the suppression of spermatogenesis in rodents.

Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells.

Signal transducer and activator of transcription-3 (Stat3) plays a critical role in implantation via progesterone receptor in uterus.

BMPR2 is required for postimplantation uterine function and pregnancy maintenance.

Loss of CDH1 and Pten accelerates cellular invasiveness and angiogenesis in the mouse uterus.

β-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition.

Critical tumor suppressor function mediated by epithelial Mig-6 in endometrial cancer.

Liver receptor homolog-1 is essential for pregnancy.

Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs.

VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy.

Progesterone signaling inhibits cervical carcinogenesis in mice.

Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells.

Integrated chromatin immunoprecipitation sequencing and microarray analysis identifies FOXA2 target genes in the glands of the mouse uterus.

Paracrine-rescued lobulogenesis in chimeric outgrowths comprising progesterone-receptor-null mammary epithelium and redirected wild-type testicular cells.

Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization.

Fibroblast growth factor receptor two (FGFR2) regulates uterine epithelial integrity and fertility in mice.

Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans.

Application of 13C isotope labeling using liquid chromatography mass spectrometry (LC-MS) to determining phosphate-containing metabolic incorporation.

A mouse model for endometrioid ovarian cancer arising from the distal oviduct.

A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells.

Activated AKT pathway promotes establishment of endometriosis.

Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function.

The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.

Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.

Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance.

The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction.

A role for site-specific phosphorylation of mouse progesterone receptor at serine 191 in vivo.

Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation.

Constitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and function.

Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation.

Maximal Dexamethasone Inhibition of Luminal Epithelial Proliferation Involves Progesterone Receptor (PR)- and Non-PR-Mediated Mechanisms in Neonatal Mouse Uterus.

Aberrant Activation of the RANK Signaling Receptor Induces Murine Salivary Gland Tumors.

Steroid receptor coactivators as therapeutic targets in the female reproductive system.

Reprint of "Steroid receptor coactivators as therapeutic targets in the female reproductive system".

ARID1A Is Essential for Endometrial Function during Early Pregnancy.

Correction: Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization.

Application of (13) C isotope labeling using liquid chromatography mass spectrometry (LC-MS) to determining phosphate-containing metabolic incorporation.

GATA4 and GATA6 Knockdown During Luteinization Inhibits Progesterone Production and Gonadotropin Responsiveness in the Corpus Luteum of Female Mice.

Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis.

Correction: Perturbing the Cellular Levels of Steroid Receptor Coactivator-2 Impairs Murine Endometrial Function.

Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization.

Uterine ALK3 is essential during the window of implantation.

Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice.

Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development.

Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus.

Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis.

The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization.

The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker.

Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts.

The essential role of GATA transcription factors in adult murine prostate.

Loss of Fertility in the Absence of Progesterone Receptor Expression in Kisspeptin Neurons of Female Mice.

A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function.

Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence.

Three-Dimensional High-Frequency Ultrasonography for Early Detection and Characterization of Embryo Implantation Site Development in the Mouse.

Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment.

A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin.

CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy.

Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase.

A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland.

Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice.

Conditional abrogation of transforming growth factor-β receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice.

PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice.

Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization.