Jian-Xing Ma

The effect of angiostatin on vascular leakage and VEGF expression in rat retina.

Suppression of corneal neovascularization by PEDF release from human amniotic membranes.

Decreased expression of pigment epithelium-derived factor is involved in the pathogenesis of diabetic nephropathy.

Targeted expression of Cre recombinase to cone photoreceptors in transgenic mice.

Systemic and periocular deliveries of plasminogen kringle 5 reduce vascular leakage in rat models of oxygen-induced retinopathy and diabetes.

RPE65 is the isomerohydrolase in the retinoid visual cycle.

Identification of conserved histidines and glutamic acid as key residues for isomerohydrolase activity of RPE65, an enzyme of the visual cycle in the retinal pigment epithelium.

RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle.

Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor.

Therapeutic potential of angiostatin in diabetic nephropathy.

Deletion of smooth muscle alpha-actin alters blood-retina barrier permeability and retinal function.

Two point mutations of RPE65 from patients with retinal dystrophies decrease the stability of RPE65 protein and abolish its isomerohydrolase activity.

Impacts of two point mutations of RPE65 from Leber's congenital amaurosis on the stability, subcellular localization and isomerohydrolase activity of RPE65.

Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy.

Ocular neovascularization: Implication of endogenous angiogenic inhibitors and potential therapy.

The roles of three palmitoylation sites of RPE65 in its membrane association and isomerohydrolase activity.

Light induces programmed cell death by activating multiple independent proteases in a cone photoreceptor cell line.

Conditional gene knockout system in cone photoreceptors.

Rat strain-dependent susceptibility to ischemia-induced retinopathy associated with retinal vascular endothelial growth factor regulation.

RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.

Very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularization.

Retinoid processing in cone and Müller cell lines.

RPE65 from cone-dominant chicken is a more efficient isomerohydrolase compared with that from rod-dominant species.

Down-regulation of angiogenic inhibitors: a potential pathogenic mechanism for diabetic complications.

Anti-inflammatory effects of pigment epithelium-derived factor in diabetic nephropathy.

Salamander blue-sensitive cones lost during metamorphosis.

Intraretinal leakage and oxidation of LDL in diabetic retinopathy.

Pigment epithelium-derived factor mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized low-density lipoprotein.

Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients.

Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65.

SERPINA3K prevents oxidative stress induced necrotic cell death by inhibiting calcium overload.

Systemic administration of HMG-CoA reductase inhibitor protects the blood-retinal barrier and ameliorates retinal inflammation in type 2 diabetes.

Photoreceptor degeneration and retinal inflammation induced by very low-density lipoprotein receptor deficiency.

Anti-inflammatory and antioxidant effects of SERPINA3K in the retina.

The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins.

Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane.

Nanoparticle-mediated expression of an angiogenic inhibitor ameliorates ischemia-induced retinal neovascularization and diabetes-induced retinal vascular leakage.

Evidence for two retinoid cycles in the cone-dominated chicken eye.

Müller cell-derived VEGF is a significant contributor to retinal neovascularization.

Pigment epithelium-derived factor suppresses adipogenesis via inhibition of the MAPK/ERK pathway in 3T3-L1 preadipocytes.

The pathogenic role of the canonical Wnt pathway in age-related macular degeneration.

Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models.

Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65.

Inhibition of connective tissue growth factor overexpression in diabetic retinopathy by SERPINA3K via blocking the WNT/beta-catenin pathway.

Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family.

PEDF as a treatment for cervical cancer.

Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease.

The potential of nanomedicine therapies to treat neovascular disease in the retina.

Wnt pathway antagonists and angiogenesis.

An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain.

Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization.

Anti-angiogenic and anti-inflammatory effects of SERPINA3K on corneal injury.

Anti-inflammatory and antiangiogenic effects of nanoparticle-mediated delivery of a natural angiogenic inhibitor.

Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity.

Comparison of ocular pathologies in vitamin A-deficient mice and RPE65 gene knockout mice.

Identification of a novel inhibitor of the canonical Wnt pathway.

An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species.

A PEDF-derived peptide inhibits retinal neovascularization and blocks mobilization of bone marrow-derived endothelial progenitor cells.

RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis.

Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity.

RPE65 is present in human green/red cones and promotes photopigment regeneration in an in vitro cone cell model.

Identification of the key residues determining the product specificity of isomerohydrolase.

Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium.

Therapeutic potential of a monoclonal antibody blocking the Wnt pathway in diabetic retinopathy.

Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization.

Therapeutic effects of PPARα agonists on diabetic retinopathy in type 1 diabetes models.

Nitrosative stress plays an important role in Wnt pathway activation in diabetic retinopathy.

Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism.

A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis.

Dual inhibition of plasminogen kringle 5 on angiogenesis and chemotaxis suppresses tumor metastasis by targeting HIF-1α pathway.

Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy.

MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model.

Increased importin 13 activity is associated with the pathogenesis of pterygium.

Antiangiogenic and antineuroinflammatory effects of kallistatin through interactions with the canonical Wnt pathway.

Pathogenic role of diabetes-induced PPAR-α down-regulation in microvascular dysfunction.

Regulation of endothelial progenitor cell release by Wnt signaling in bone marrow.

Coexpression of three opsins in cone photoreceptors of the salamander Ambystoma tigrinum.

Inhibition of pathological corneal neovascularization by a small peptide derived from human apolipoprotein (a) Kringle V.

Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling.

Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients.

Immune complex formation in human diabetic retina enhances toxicity of oxidized LDL towards retinal capillary pericytes.

Protective and antioxidant effects of PPARα in the ischemic retina.

PPARα regulates mobilization and homing of endothelial progenitor cells through the HIF-1α/SDF-1 pathway.

Serine Proteinase Inhibitor SERPINA3K Suppresses Corneal Neovascularization via Inhibiting Wnt Signaling and VEGF.

Peroxisome proliferator-activated receptor α protects capillary pericytes in the retina.

Identification of key residues determining isomerohydrolase activity of human RPE65.

Nanoparticle-assisted targeted delivery of eye-specific genes to eyes significantly improves the vision of blind mice in vivo.

Receptor heterodimerization as a novel mechanism for the regulation of Wnt/β-catenin signaling.

Interruption of Wnt signaling in Müller cells ameliorates ischemia-induced retinal neovascularization.

SERPINA3K plays antioxidant roles in cultured pterygial epithelial cells through regulating ROS system.

High levels of pigment epithelium-derived factor in diabetes impair wound healing through suppression of Wnt signaling.

Posttranslational modification of Sirt6 activity by peroxynitrite.

Nanoparticle-mediated expression of a Wnt pathway inhibitor ameliorates ocular neovascularization.

Angiogenesis in diabetes and obesity.

Therapeutic Effects of PPAR α on Neuronal Death and Microvascular Impairment.

Identification of active retinaldehyde dehydrogenase isoforms in the postnatal human eye.

MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization.

Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development.

PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases.

The oxidant role of 4-hydroxynonenal in corneal epithelium.

Wnt signaling in age-related macular degeneration: human macular tissue and mouse model.

Down-Regulation of MicroRNA-184 Is Associated With Corneal Neovascularization.

The regulatory role of hepatoma-derived growth factor as an angiogenic factor in the eye.

sFlt Multivalent Conjugates Inhibit Angiogenesis and Improve Half-Life In Vivo.

Extravascular modified lipoproteins: a role in the propagation of diabetic retinopathy in a mouse model of type 1 diabetes.

Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications.

Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling.

Interaction of PPARα With the Canonic Wnt Pathway in the Regulation of Renal Fibrosis.

Postnatal Chick Choroids Exhibit Increased Retinaldehyde Dehydrogenase Activity During Recovery From Form Deprivation Induced Myopia.

Complete metabolome and lipidome analysis reveals novel biomarkers in the human diabetic corneal stroma.

ROS-mediated Different Homeostasis of Murine Corneal Epithelial Progenitor Cell Line under Oxidative Stress.

Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway.

Establishment of a 3D In Vitro Model to Accelerate the Development of Human Therapies against Corneal Diabetes.

A Dominant Mutation in Rpe65, D477G, Delays Dark Adaptation and Disturbs the Visual Cycle in the Mutant Knock-In Mice.

Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARα.

Transgenic expression of a canonical Wnt inhibitor, kallistatin, is associated with decreased circulating CD19+ B lymphocytes in the peripheral blood.

Inhibition of Stat3 by a Small Molecule Inhibitor Slows Vision Loss in a Rat Model of Diabetic Retinopathy.

Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration.

Canonical Wnt signaling in diabetic retinopathy.

SERPINA3K Ameliorates the Corneal Oxidative Injury Induced by 4-Hydroxynonenal.

Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy.

Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration.

Unravelling the stromal-nerve interactions in the human diabetic cornea.

Therapeutic Effects of a Novel Agonist of Peroxisome Proliferator-Activated Receptor Alpha for the Treatment of Diabetic Retinopathy.

Therapeutic Effects of PPARα Agonist on Ocular Neovascularization in Models Recapitulating Neovascular Age-Related Macular Degeneration.

PPARα is essential for retinal lipid metabolism and neuronal survival.