Pinchas Cohen

Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model.

Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety.

Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation.

Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer.

IGFBP-3 mediates p53-induced apoptosis during serum starvation.

Diagnosis and management of growth hormone deficiency in childhood and adolescence--part 2: growth hormone treatment in growth hormone deficient children.

Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis.

IGFs and IGFBPs: role in health and disease.

Rapid insulin-like growth factor (IGF)-independent effects of IGF binding protein-3 on endothelial cell survival.

Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States).

Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells.

Type Ialpha collagen is an IGFBP-3 binding protein.

Insulin-like growth factor I (IGF-I) and IGF binding protein-1 modulate prostate cancer cell growth and apoptosis: possible mediators for the effects of diet and exercise on cancer cell survival.

Statement 1: a serum insulin-like growth factor I (IGF-I) level should be part of the evaluation of children with short stature.

Individualized growth hormone therapy in children: advances beyond weight-based dosing.

Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells.

Effect of isocaloric low-fat diet on human LAPC-4 prostate cancer xenografts in severe combined immunodeficient mice and the insulin-like growth factor axis.

A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation.

Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.

Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee.

Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization.

Insulin-like growth factors and their binding proteins in children born small for gestational age: implication for growth hormone therapy.

Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells.

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults.

Insulin-like growth factor binding protein-3 is a novel mediator of apoptosis in insulin-secreting cells.

EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

Is treatment with growth hormone effective in children with cerebral palsy?

Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition.

Overexpression of gly56/gly80/gly81-mutant insulin-like growth factor-binding protein-3 in transgenic mice.

Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77.

The role of insulin-like growth factor I monitoring in growth hormone-treated children.

p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia.

Pharmacodynamic considerations with recombinant human insulin-like growth factor-I in children.

Combination therapy of insulin-like growth factor binding protein-3 and retinoid X receptor ligands synergize on prostate cancer cell apoptosis in vitro and in vivo.

Insulin-like growth factor I (IGF-I) measurements in growth hormone (GH) therapy of idiopathic short stature (ISS).

Control of aging and longevity by IGF-I signaling.

The role of the insulin-like growth factor system in prenatal growth.

Racial differences in prognostic value of adult height for biochemical progression following radical prostatectomy.

Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma.

Ribonucleic acid polymerase II binding subunit 3 (Rpb3), a potential nuclear target of insulin-like growth factor binding protein-3.

Overview of the IGF-I system.

Insulin-like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcoma.

Insulin-like growth factor binding protein-3: insulin-like growth factor independence comes of age.

Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis.

The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone.

Advances in pediatric growth hormone therapy: IGF-I-based dosing.

Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2.

Controversy in clinical endocrinology: problems with reclassification of insulin-like growth factor I production and action disorders.

Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action.

Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3.

Growth hormone therapy improves bone mineral density in children with cerebral palsy: a preliminary pilot study.

Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo.

Insulin growth factor-based dosing of growth hormone therapy in children: a randomized, controlled study.

Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3.

Hormonal regulation of IGFBP-2 proteolysis is attenuated with progression to androgen insensitivity in the LNCaP progression model.

Treatment perspectives in idiopathic short stature with a focus on IGF-I deficiency.

Quantitative ontogeny of murine insulin-like growth factor (IGF)-I, IGF-binding protein-3 and the IGF-related acid-labile subunit.

Spinal bone mineral density, IGF-1 and IGFBP-3 in children with cerebral palsy.

A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer.

The somatomedin hypothesis 2007: 50 years later.

Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis.

Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model.

Functionally significant insulin-like growth factor I receptor mutations in centenarians.

SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice.

Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression.

Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice.

Lost in translation?

Surprising new height regulating genes: beyond growth hormone and IGF-I.

Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.

PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions.

Optimizing growth hormone dosing in children with idiopathic short stature.

Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.

The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model.

Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation.

Humanin: a novel central regulator of peripheral insulin action.

Growth hormone treatment: evidence, practice, and emerging issues.

Clinical management of growth hormone therapy for children.

The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice.

Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis.

Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis.

Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer.

Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis.

Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index.

Fasting and cancer treatment in humans: A case series report.

Effect of intermittent fasting with or without caloric restriction on prostate cancer growth and survival in SCID mice.

Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children.

Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress.

Chemoprevention of prostate cancer with lycopene in the TRAMP model.

Endocrine actions of myostatin: systemic regulation of the IGF and IGF binding protein axis.

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.

IGFBP-3 is a metastasis suppression gene in prostate cancer.

Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice.

Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice.

Global Igfbp1 deletion does not affect prostate cancer development in a c-Myc transgenic mouse model.

How useful are serum IGF-I measurements for managing GH replacement therapy in adults and children?

Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy.

Long-term surveillance of growth hormone therapy.

Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans.

Effect of a low-fat diet combined with IGF-1 receptor blockade on 22Rv1 prostate cancer xenografts.

Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice.

Efficacy of IGF-based growth hormone (GH) dosing in nonGH-deficient (nonGHD) short stature children with low IGF-I is not related to basal IGF-I levels.

IGFBP-3 nuclear localization predicts human prostate cancer recurrence.

Growth hormone receptor (GHR) exon 3 polymorphism status detection by dual-enzyme-linked immunosorbent assay (ELISA).

Resveratrol worsens survival in SCID mice with prostate cancer xenografts in a cell-line specific manner, through paradoxical effects on oncogenic pathways.

The emerging role of the mitochondrial-derived peptide humanin in stress resistance.

Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.

Humanin: a harbinger of mitochondrial-derived peptides?

Response of the insulin-like growth factor (IGF) system to IGF-IR inhibition and androgen deprivation in a neoadjuvant prostate cancer trial: effects of obesity and androgen deprivation.

Prepubertal children with growth hormone deficiency treated for four years with growth hormone experience dose-dependent increase in height, but not in the rate of puberty initiation.

Effects of calorie restriction and IGF-1 receptor blockade on the progression of 22Rv1 prostate cancer xenografts.

Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents.

Effect of a low-fat fish oil diet on proinflammatory eicosanoids and cell-cycle progression score in men undergoing radical prostatectomy.

Dose-sparing and safety-enhancing effects of an IGF-I-based dosing regimen in short children treated with growth hormone in a 2-year randomized controlled trial: therapeutic and pharmacoeconomic considerations.

IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice.

New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects.

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity.

IGF-I regulates the age-dependent signaling peptide humanin.

The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus.

The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs.

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production.

Status of long-acting-growth hormone preparations--2015.

The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.

Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline.

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.

Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations.

Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers.

MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.

Safety and feasibility of fasting in combination with platinum-based chemotherapy.

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Effect of Dietary Omega-3 Fatty Acids on Tumor-Associated Macrophages and Prostate Cancer Progression.

The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus.

Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function.

Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione.

Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice.

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease.

Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes.

Mitochondrial DNA Hypomethylation Is a Biomarker Associated with Induced Senescence in Human Fetal Heart Mesenchymal Stem Cells.

Mitochondrially derived peptides as novel regulators of metabolism.

Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.

Feeling misguided: a comment on the US guidelines on growth hormone and insulin-like growth factor-I treatment in children and adolescents.

The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature.

Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage.

The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity.