State Key Laboratory of Reproductive Medicine,
Institute of Toxicology,
Key Laboratory of Modern Toxicology of Ministry of Education,
School of Public Health,
State Key Laboratory of Reproductive Medicine, Institute of Toxicology,
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health
Research Interests
Reproductive and Developmental Toxicology: a) The hazard of environmental-genetic dangerous factors and their interactions to reproduction and development; b) The study of developmental toxicology and environmental toxicology using zebrafish model system; c) The key roles of DNA damage repair events in important time windows during gametogenesis and embryogenesis;
[Phospholipase C and reproduction].
Zhonghua nan ke xue = National journal of andrology Jul, 2004 | Pubmed ID: 15354530
The association of Y chromosome haplogroups with spermatogenic failure in the Han Chinese.
Journal of human genetics , 2007 | Pubmed ID: 17558462
Polymorphisms in CYP1A1 gene are associated with male infertility in a Chinese population.
International journal of andrology Sep, 2008 | Pubmed ID: 17651397
The relation between urinary metabolite of pyrethroid insecticides and semen quality in humans.
Fertility and sterility Jun, 2008 | Pubmed ID: 17765231
DNA repair gene XRCC1 and XPD polymorphisms and the risk of idiopathic azoospermia in a Chinese population.
International journal of molecular medicine Nov, 2007 | Pubmed ID: 17912469
XPC gene polymorphisms and risk of idiopathic azoospermia or oligozoospermia in a Chinese population.
International journal of andrology Jun, 2009 | Pubmed ID: 18067564
ERCC1 and ERCC2 polymorphisms and risk of idiopathic azoospermia in a Chinese population.
Reproductive biomedicine online Jul, 2008 | Pubmed ID: 18616887
The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population.
Human molecular genetics Mar, 2009 | Pubmed ID: 19088127
FAS and FASLG polymorphisms and susceptibility to idiopathic azoospermia or severe oligozoospermia.
Reproductive biomedicine online Jan, 2009 | Pubmed ID: 19146781
Urinary metabolites of polycyclic aromatic hydrocarbons in relation to idiopathic male infertility.
Human reproduction (Oxford, England) May, 2009 | Pubmed ID: 19202139
Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality.
Human reproduction (Oxford, England) Oct, 2009 | Pubmed ID: 19542541
Relation between urinary metabolites of polycyclic aromatic hydrocarbons and human semen quality.
Environmental science & technology Jun, 2009 | Pubmed ID: 19603678
Variants in the Eppin gene show association with semen quality in Han-Chinese population.
Reproductive biomedicine online Jan, 2010 | Pubmed ID: 20158997
Lack of association between DAZ gene methylation patterns and spermatogenic failure.
Clinical chemistry and laboratory medicine Mar, 2010 | Pubmed ID: 20170395
Joint effects of XRCC1 polymorphisms and polycyclic aromatic hydrocarbons exposure on sperm DNA damage and male infertility.
Toxicological sciences : an official journal of the Society of Toxicology Jul, 2010 | Pubmed ID: 20395310
Nucleotide excision repair polymorphisms, polycyclic aromatic hydrocarbon exposure, and their effects on sperm deoxyribonucleic acid damage and male factor infertility.
Fertility and sterility Dec, 2010 | Pubmed ID: 20557883
Exposure to fenvalerate causes brain impairment during zebrafish development.
Toxicology letters Sep, 2010 | Pubmed ID: 20570613
Polymorphisms of nucleotide-excision repair genes may contribute to sperm DNA fragmentation and male infertility.
Reproductive biomedicine online Nov, 2010 | Pubmed ID: 20864414
Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population.
Human reproduction (Oxford, England) Dec, 2010 | Pubmed ID: 20940137
Effects of non-occupational environmental exposure to pyrethroids on semen quality and sperm DNA integrity in Chinese men.
Reproductive toxicology (Elmsford, N.Y.) Feb, 2011 | Pubmed ID: 20955780
Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm.
PloS one Oct, 2010 | Pubmed ID: 20957144
FSH receptor gene polymorphisms in fertile and infertile Han-Chinese males.
Clinica chimica acta; international journal of clinical chemistry May, 2011 | Pubmed ID: 21334319
Distribution of Eppin in mouse and human testis.
Molecular medicine reports Jan-Feb, 2011 | Pubmed ID: 21461566
Assessment of an association between an aryl hydrocarbon receptor gene (AHR) polymorphism and risk of male infertility.
Toxicological sciences : an official journal of the Society of Toxicology Aug, 2011 | Pubmed ID: 21613234
Latent TGF-β binding protein 3 identifies a second heart field in zebrafish.
Nature Jun, 2011 | Pubmed ID: 21623370
Developmental toxicity of cypermethrin in embryo-larval stages of zebrafish.
Chemosphere Oct, 2011 | Pubmed ID: 21840035
Additional genomic duplications in AZFc underlie the b2/b3 deletion-associated risk of spermatogenic impairment in Han Chinese population.
Human molecular genetics Nov, 2011 | Pubmed ID: 21852246
Genetic variants in antioxidant genes are associated with sperm DNA damage and risk of male infertility in a Chinese population.
Free radical biology & medicine Feb, 2012 | Pubmed ID: 22206979
The TERT rs2736100 polymorphism and cancer risk: a meta-analysis based on 25 case-control studies.
BMC cancer , 2012 | Pubmed ID: 22221621
The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis.
PloS one , 2012 | Pubmed ID: 22276117
Contributions of aryl hydrocarbon receptor genetic variants to the risk of glioma and PAH-DNA adducts.
Toxicological sciences : an official journal of the Society of Toxicology Aug, 2012 | Pubmed ID: 22539616
Common variants in mismatch repair genes associated with increased risk of sperm DNA damage and male infertility.
BMC medicine May, 2012 | Pubmed ID: 22594646
The aryl hydrocarbon receptor (AhR) 1661G>A polymorphism in human cancer: a meta-analysis.
Gene Jan, 2013 | Pubmed ID: 23022626
Association of the maternal MTHFR C677T polymorphism with susceptibility to neural tube defects in offsprings: evidence from 25 case-control studies.
PloS one , 2012 | Pubmed ID: 23056169
Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population.
PloS one , 2013 | Pubmed ID: 23320086
Neurotoxicity of perfluorooctane sulfonate to hippocampal cells in adult mice.
PloS one , 2013 | Pubmed ID: 23382877
The TERT MNS16A polymorphism contributes to cancer susceptibility: meta-analysis of the current studies.
Gene May, 2013 | Pubmed ID: 23462332
Hsa-mir-499 rs3746444 polymorphism and cancer risk: a meta-analysis.
Journal of biomedical research Jul, 2012 | Pubmed ID: 23554757
Low-dose monobutyl phthalate stimulates steroidogenesis through steroidogenic acute regulatory protein regulated by SF-1, GATA-4 and C/EBP-beta in mouse Leydig tumor cells.
Reproductive biology and endocrinology : RB&E Jul, 2013 | Pubmed ID: 23889939
8-Oxoguanine DNA glycosylase 1 (ogg1) maintains the function of cardiac progenitor cells during heart formation in zebrafish.
Experimental cell research Nov, 2013 | Pubmed ID: 23892003
IDH1/IDH2 mutations define the prognosis and molecular profiles of patients with gliomas: a meta-analysis.
PloS one , 2013 | Pubmed ID: 23894344
Bulky DNA adducts in human sperm associated with semen parameters and sperm DNA fragmentation in infertile men: a cross-sectional study.
Environmental health : a global access science source Sep, 2013 | Pubmed ID: 24073787
The 8-oxoguanine DNA glycosylase 1 (ogg1) decreases the vulnerability of the developing brain to DNA damage.
DNA repair Dec, 2013 | Pubmed ID: 24075420
Estrogen receptors are involved in polychlorinated biphenyl-induced apoptosis on mouse spermatocyte GC-2 cell line.
Toxicology in vitro : an international journal published in association with BIBRA Apr, 2014 | Pubmed ID: 24216299
Genetic variants in telomerase reverse transcriptase (TERT) and telomerase-associated protein 1 (TEP1) and the risk of male infertility.
Gene Jan, 2014 | Pubmed ID: 24269974
Association between CTLA-4 60G/A and -1661A/G polymorphisms and the risk of cancers: a meta-analysis.
PloS one , 2013 | Pubmed ID: 24376736
Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish.
Journal of hematology & oncology Mar, 2014 | Pubmed ID: 24598081
Seminal superoxide dismutase activity and its relationship with semen quality and SOD gene polymorphism.
Journal of assisted reproduction and genetics May, 2014 | Pubmed ID: 24658925
Association of interferon regulatory factor 4 gene polymorphisms rs12203592 and rs872071 with skin cancer and haematological malignancies susceptibility: a meta-analysis of 19 case-control studies.
BMC cancer Jun, 2014 | Pubmed ID: 24906573
Association between the XRCC1 Arg194Trp polymorphism and glioma risk: an updated meta-analysis.
Asian Pacific journal of cancer prevention : APJCP , 2014 | Pubmed ID: 25227852
Increased incidence of head and neck cancer in liver transplant recipients: a meta-analysis.
BMC cancer Oct, 2014 | Pubmed ID: 25338638
Association between HIF-1α C1772T/G1790A polymorphisms and cancer susceptibility: an updated systematic review and meta-analysis based on 40 case-control studies.
BMC cancer Dec, 2014 | Pubmed ID: 25496056
Genetic variants in nitric oxide synthase genes and the risk of male infertility in a Chinese population: a case-control study.
PloS one , 2014 | Pubmed ID: 25517965
Urinary enterolactone is associated with obesity and metabolic alteration in men in the US National Health and Nutrition Examination Survey 2001-10.
The British journal of nutrition Feb, 2015 | Pubmed ID: 25634494
Altered profile of gut microbiota after subchronic exposure to neochamaejasmin A in rats.
Environmental toxicology and pharmacology Mar, 2015 | Pubmed ID: 25812769
Urinary enterolactone associated with liver enzyme levels in US adults: National Health and Nutrition Examination Survey (NHANES).
The British journal of nutrition Jul, 2015 | Pubmed ID: 25990984
Low Serum Testosterone Levels Are Associated with Elevated Urinary Mandelic Acid, and Strontium Levels in Adult Men According to the US 2011-2012 National Health and Nutrition Examination Survey.
PloS one , 2015 | Pubmed ID: 25996772
Effects of urban particulate matter with high glucose on human monocytes U937.
Journal of applied toxicology : JAT Apr, 2016 | Pubmed ID: 26179980
miRNA-200c mediates mono-butyl phthalate-disrupted steroidogenesis by targeting vimentin in Leydig tumor cells and murine adrenocortical tumor cells.
Toxicology letters Jan, 2016 | Pubmed ID: 26581634
Association of polycyclic aromatic hydrocarbons and asthma among children 6-19 years: NHANES 2001-2008 and NHANES 2011-2012.
Respiratory medicine Jan, 2016 | Pubmed ID: 26626452
Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease.
Oncotarget Jun, 2016 | Pubmed ID: 27203212
Sublethal effects of zinc oxide nanoparticles on male reproductive cells.
Toxicology in vitro : an international journal published in association with BIBRA Sep, 2016 | Pubmed ID: 27247145
Toxicological assessment of multi-walled carbon nanotubes in vitro: potential mitochondria effects on male reproductive cells.
Oncotarget Jun, 2016 | Pubmed ID: 27248475
Perfluorooctane sulfonate-induced testicular toxicity and differential testicular expression of estrogen receptor in male mice.
Environmental toxicology and pharmacology Jul, 2016 | Pubmed ID: 27310206
Association between level of urinary trace heavy metals and obesity among children aged 6-19 years: NHANES 1999-2011.
Environmental science and pollution research international Apr, 2017 | Pubmed ID: 28321702
Estrogen receptor beta mediates hepatotoxicity induced by perfluorooctane sulfonate in mouse.
Environmental science and pollution research international May, 2017 | Pubmed ID: 28386898
Organochloride pesticides modulated gut microbiota and influenced bile acid metabolism in mice.
Environmental pollution (Barking, Essex : 1987) Jul, 2017 | Pubmed ID: 28392238
Organochloride pesticides impaired mitochondrial function in hepatocytes and aggravated disorders of fatty acid metabolism.
Scientific reports 04, 2017 | Pubmed ID: 28397872
Ibrutinib, a Bruton's tyrosine kinase inhibitor, exhibits antitumoral activity and induces autophagy in glioblastoma.
Journal of experimental & clinical cancer research : CR 07, 2017 | Pubmed ID: 28716053
NF-κB-vimentin is involved in steroidogenesis stimulated by mono-butyl phthalate in primary cultured ovarian granulosa cells.
Toxicology in vitro : an international journal published in association with BIBRA Dec, 2017 | Pubmed ID: 28735033
Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer's Disease-like Neurotoxicity.
Scientific reports 08, 2017 | Pubmed ID: 28790390
Effect of exposure to ambient PM pollution on the risk of respiratory tract diseases: a meta-analysis of cohort studies.
Journal of biomedical research Jan, 2017 | Pubmed ID: 28808195
, a long-noncoding RNA, promotes malignancy in glioblastoma.
OncoTargets and therapy , 2017 | Pubmed ID: 28894380
Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes.
Proceedings of the National Academy of Sciences of the United States of America 11, 2017 | Pubmed ID: 29078374
Involvement of the delayed rectifier outward potassium channel Kv2.1 in methamphetamine-induced neuronal apoptosis via the p38 mitogen-activated protein kinase signaling pathway.
Journal of applied toxicology : JAT 05, 2018 | Pubmed ID: 29297590
Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis.
Cell death & disease 08, 2018 | Pubmed ID: 30068904
NF-κB-vimentin is involved in steroidogenesis stimulated by di--butyl phthalate in prepubertal female rats.
Toxicology research Sep, 2018 | Pubmed ID: 30310660
RhoG-ELMO1-RAC1 is involved in phagocytosis suppressed by mono-butyl phthalate in TM4 cells.
Environmental science and pollution research international Dec, 2018 | Pubmed ID: 30350139
Neurobehavioral effects of bisphenol S exposure in early life stages of zebrafish larvae (Danio rerio).
Chemosphere Feb, 2019 | Pubmed ID: 30447611
Quantification of Mitochondrial Genome Transcription in Male Reproductive Cells by Real-Time PCR.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 30547462
Deficiency of X-ray repair cross-complementing group 1 in primordial germ cells contributes to male infertility.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 06, 2019 | Pubmed ID: 30998386
FMO3 and its metabolite TMAO contribute to the formation of gallstones.
Biochimica et biophysica acta. Molecular basis of disease 10, 2019 | Pubmed ID: 31251986
Association of smoking with coronary artery disease in Nepalese populations: a case control study.
Toxicology research Sep, 2019 | Pubmed ID: 31588344
SREBP2-STARD4 is involved in synthesis of cholesteryl ester stimulated by mono-butyl phthalate in MLTC-1 cells.
Environmental toxicology Mar, 2020 | Pubmed ID: 31705742
Oxidative stress in bisphenol AF-induced cardiotoxicity in zebrafish and the protective role of N-acetyl N-cysteine.
The Science of the total environment Aug, 2020 | Pubmed ID: 32408210
Di-n-butyl phthalate promotes lipid accumulation via the miR200c-5p-ABCA1 pathway in THP-1 macrophages.
Environmental pollution (Barking, Essex : 1987) Sep, 2020 | Pubmed ID: 32417575
Increased serum levels of aldehydes are associated with cardiovascular disease and cardiovascular risk factors in adults.
Journal of hazardous materials Jun, 2020 | Pubmed ID: 32569983
In vitro evaluation of the hepatic lipid accumulation of bisphenol analogs: A high-content screening assay.
Toxicology in vitro : an international journal published in association with BIBRA Oct, 2020 | Pubmed ID: 32763284
1State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University,
2Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University,
3Center of Gallbladder Disease, Shanghai East Hospital, Institute of Gallstone Disease, Tongji University School of Medicine
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