Richard Simpson

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.

Informed consent: from disclosure to patient participation in medical decisionmaking.

Opening doors with assistive technology.

Isolation and characterisation of a 13.8-kDa bacteriolytic enzyme from house dust mite extracts: homology with prokaryotic proteins suggests that the enzyme could be bacterially derived.

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.

Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking.

Mutation detection using mass spectrometric separation of tiny oligonucleotide fragments.

Characterization of an antagonist interleukin-6 dimer by stable isotope labeling, cross-linking, and mass spectrometry.

The Hephaestus Smart Wheelchair System.

Voice control of a powered wheelchair.

CHOMPER: a bioinformatic tool for rapid validation of tandem mass spectrometry search results associated with high-throughput proteomic strategies.

Introduction to Michel de M'Uzan's "Slaves of quantity".

Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D.

Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5.

Use of a Social Story intervention to improve mealtime skills of an adolescent with Asperger syndrome.

Mechanisms of action of intrathecal medications.

Task imposed on prisons is impossible.

Mining a tandem mass spectrometry database to determine the trends and global factors influencing peptide fragmentation.

Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion.

Chiral separation of labetalol stereoisomers in human plasma by capillary electrophoresis.

The development and preliminary evaluation of a decision aid based on decision analysis for two treatment conditions: benign prostatic hyperplasia and hypertension.

The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation.

Effects of QD insulin detemir or neutral protamine Hagedorn on blood glucose control in patients with type I diabetes mellitus using a basal-bolus regimen.

Introduction to Jean-Jacques Blévis's "remains to be transmitted: Primo Levi's traumatic dream".

A proteome strategy for fractionating proteins and peptides using continuous free-flow electrophoresis coupled off-line to reversed-phase high-performance liquid chromatography.

Insulin and oleate promote translocation of inosine-5' monophosphate dehydrogenase to lipid bodies.

Statistical and mechanistic approaches to understanding the gas-phase fragmentation behavior of methionine sulfoxide containing peptides.

Effects on communicative requesting and speech development of the Picture Exchange Communication System in children with characteristics of autism.

A common open representation of mass spectrometry data and its application to proteomics research.

The smart wheelchair component system.

[From genome to proteome--aim of human proteomics].

Long-term deep brain stimulation in elderly patients with cardiac pacemakers.

Breast cancer protein StarD10 identified by three-dimensional separation using free-flow electrophoresis, reversed-phase high-performance liquid chromatography, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis.

The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist.

Selective identification and quantitative analysis of methionine containing peptides by charge derivatization and tandem mass spectrometry.

Immune alterations, lipid peroxidation, and muscle damage following a hill race.

An evaluation, comparison, and accurate benchmarking of several publicly available MS/MS search algorithms: sensitivity and specificity analysis.

Application of 2-D free-flow electrophoresis/RP-HPLC for proteomic analysis of human plasma depleted of multi high-abundance proteins.

Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database.

A prototype power assist wheelchair that provides for obstacle detection and avoidance for those with visual impairments.

Proteomic analysis of colorectal cancer: discovering novel biomarkers.

Liquid-based free-flow electrophoresis-reversed-phase HPLC: a proteomic tool.

Smart wheelchairs: A literature review.

Treatment of intractable painful diabetic neuropathy with intravenous lignocaine.

Virtual reality and computer-enhanced training applied to wheeled mobility: an overview of work in Pittsburgh.

Guidelines for the next 10 years of proteomics.

A proteomic approach for unraveling the oncogenic H-Ras protein networks in NIH/3T3 mouse embryonic fibroblast cells.

The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (beta2 integrin) and CD53.

Metabolism and disposition of a potent and selective GABA-Aalpha2/3 receptor agonist in healthy male volunteers.

Physiological variables and performance markers of serving soldiers from two "elite" units of the British Army.

Long-term evaluation of deep brain stimulation of the thalamus.

Anal manometry: a comparison of techniques.

In situ phosphorylation of immobilized receptors on biosensor surfaces: application to E-cadherin/beta-catenin interactions.

The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells.

Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation.

Mental Health Act: why not learn from devolution?

Expression of a fungal phytase gene in Nicotiana tabacum improves phosphorus nutrition of plants grown in amended soils.

Impact of repeated prolonged exercise bouts on cardiac function and biomarkers.

Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.

High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects.

Short-term and long-term safety of deep brain stimulation in the treatment of movement disorders.

Analysis of Ras-induced oncogenic transformation of NIH-3T3 cells using differential-display 2-DE proteomics.

Miniaturized asymmetrical flow field-flow fractionation: application to biological vesicles.

Selecting an appropriate scan rate: the ".65 rule".

Nanoparticle interactions with zinc and iron: implications for toxicology and inflammation.

Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise.

Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans.

A letter to Hans Loewald.

Retinal arteriolar narrowing predicts incidence of diabetes: the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study.

Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise.

Participatory design in the development of the wheelchair convoy system.

Glucagon-like peptide-1 attenuates tumour necrosis factor-alpha-mediated induction of plasminogen [corrected] activator inhibitor-1 expression.

Human Proteinpedia enables sharing of human protein data.

Proteomics-driven cancer biomarker discovery: looking to the future.

Making better decisions.

Generalization of a pictorial alternative communication system across instructors and distance.

Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.

How many people would benefit from a smart wheelchair?

Proteomic analysis of colorectal cancer: prefractionation strategies using two-dimensional free-flow electrophoresis.

Human microglial cells synthesize albumin in brain.

Distributed cognitive aid with scheduling and interactive task guidance.

Gonadotroph adenoma in multiple endocrine neoplasia type 1.

Proteomic profiling of exosomes: current perspectives.

Toward automatic adjustment of pointing device configuration to accommodate physical impairment.

Toll-like receptor expression on classic and pro-inflammatory blood monocytes after acute exercise in humans.

A perspective on intelligent devices and environments in medical rehabilitation.

Stem cell markers: insights from membrane proteomics?

Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte.

Olig2-induced neural stem cell differentiation involves downregulation of Wnt signaling and induction of Dickkopf-1 expression.

A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules.

Purification of basolateral integral membrane proteins by cationic colloidal silica-based apical membrane subtraction.

Isolation of extracellular membranous vesicles for proteomic analysis.

Enrichment of human platelet membranes for proteomic analysis.

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.

Toward automatic adjustment of keyboard settings for people with physical impairments.

Secretome-based proteomic profiling of Ras-transformed MDCK cells reveals extracellular modulators of epithelial-mesenchymal transition.

Clinical evaluation of Guido robotic walker.

Towards understanding epithelial-mesenchymal transition: a proteomics perspective.

Exosomes: proteomic insights and diagnostic potential.

Transgenic barley (Hordeum vulgare L.) expressing the wheat aluminium resistance gene (TaALMT1) shows enhanced phosphorus nutrition and grain production when grown on an acid soil.

Whipple disease of the central nervous system: an unusual occurrence in association with acquired immune deficiency syndrome.

International blood collection and storage: clinical use of blood products.

Relationship between neuropsychological outcome and DBS surgical trajectory and electrode location.

A centrifugal ultrafiltration strategy for isolating the low-molecular weight (<or=25K) component of human plasma proteome.

ExoCarta: A compendium of exosomal proteins and RNA.

Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature.

Research in computer access assessment and intervention.

Extracellular remodelling during oncogenic Ras-induced epithelial-mesenchymal transition facilitates MDCK cell migration.

Coupling aging immunity with a sedentary lifestyle: has the damage already been done?--a mini-review.

Long-term deep brain stimulation for essential tremor: 12-year clinicopathologic follow-up.

An aspartyl protease directs malaria effector proteins to the host cell.

Analyzing performance with computer access technology using unconstrained text entry protocol.

Differential expression of pathogen-recognition molecules between dendritic cell subsets revealed by plasma membrane proteomic analysis.

Pouring linear gradient gels with a gradient former.

CTAB-PAGE.

Rapid coomassie blue staining of protein gels.

SYPRO Orange fluorescent staining of protein gels.

Stabilization of proteins for storage.

The Asia Oceania Human Proteome Organisation Membrane Proteomics Initiative. Preparation and characterisation of the carbonate-washed membrane standard.

A single case design evaluation of a software and tutor intervention addressing emotion recognition and social interaction in four boys with ASD.

Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression.

Proteomics profiling of Madin-Darby canine kidney plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition.

Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease.

Exosomes: extracellular organelles important in intercellular communication.

Homogenization of mammalian tissue.

Is a gene-centric human proteome project the best way for proteomics to serve biology?

Nonlinear temporal organization of neuronal discharge in the basal ganglia of Parkinson's disease patients.

Nonlinear temporal organization of neuronal discharge in the basal ganglia of Parkinson's disease patients.

Defining a longitudinal survival model to examine forced treadmill running as a countermeasure for diet-induced weight gain.

The impact of acute strenuous exercise on TLR2, TLR4 and HLA.DR expression on human blood monocytes induced by autologous serum.

Small-scale extraction of recombinant proteins from bacteria.

Large-scale extraction of recombinant proteins from bacteria.

Solubilization of Escherichia coli recombinant proteins from inclusion bodies.

Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans.

Perceived exertion and heart rate models for estimating metabolic workload in elite British soldiers performing a backpack load-carriage task.

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial.

PPARγ-independent thiazolidinedione-mediated inhibition of NUR77 expression in vascular endothelial cells.

Disruption of cultured cells by nitrogen cavitation.

Effect of soil acidity, soil strength and macropores on root growth and morphology of perennial grass species differing in acid-soil resistance.

Aging, persistent viral infections, and immunosenescence: can exercise "make space"?

Body fluid proteomics: Prospects for biomarker discovery.

Comparison of human platelet membrane-cytoskeletal proteins with the plasma proteome: Towards understanding the platelet-plasma nexus.

Secretome-based proteomics reveals sulindac-modulated proteins released from colon cancer cells.

Evaluation of semiautonomous navigation assistance system for power wheelchairs with blindfolded nondisabled individuals.

Genomics and proteomics in stem cell research: the road ahead.

Preparation of extracts from yeast.

Triton X-114 phase separation in the isolation and purification of mouse liver microsomal membrane proteins.

Cognitive outcome and reliable change indices two years following bilateral subthalamic nucleus deep brain stimulation.

Tandem application of cationic colloidal silica and Triton X-114 for plasma membrane protein isolation and purification: towards developing an MDCK protein database.

In-gel s-pyridylethylation of gel-resolved proteins: whole gel method.

In-gel s-pyridylethylation of gel-resolved proteins: individual spot method.

Quantifying protein by bicinchoninic Acid.

Estimation of Free Thiols and Disulfide Bonds Using Ellman's Reagent.

Reduction and s-carboxymethylation of proteins: microscale method.

Reduction and s-carboxymethylation of proteins: large-scale method.

In Situ SDS-PAGE Peptide-Mapping Procedure (Cleveland Method).

SDS-PAGE Peptide-Mapping Procedure (Cleveland Method).

Fabricating protein arrays.

Cleavage of asn-gly bonds by hydroxylamine.

Performic Acid oxidation of proteins.

Cleavage at Tryptophan by o-Iodosobenzoic Acid.

Cleavage at met-x bonds by cyanogen bromide.

Assays with protein arrays.

Nomenclature on proteases, proteinases, and peptidases.

Zinc/Imidazole procedure for visualization of proteins in gels by negative staining.

Staining proteins in gels with coomassie blue.

Staining proteins in gels with silver nitrate.

Crystal structure of the Leishmania major MIX protein: a scaffold protein that mediates protein-protein interactions.

Low-molecular weight plasma proteome analysis using centrifugal ultrafiltration.

A fluorescent microsphere-based method for assay of multiple analytes in plasma.

A protocol for the preparation of cryoprecipitate and cryodepleted plasma.

Preparation of platelet concentrates.

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model.

Soil microorganisms mediating phosphorus availability update on microbial phosphorus.

Performance testing of collision-avoidance system for power wheelchairs.

Diagnosis and treatment of complications related to deep brain stimulation hardware.

Aerobic fitness is associated with lower proportions of senescent blood T-cells in man.

Proteomic profiling of secretome and adherent plasma membranes from distinct mammary epithelial cell subpopulations.

Response to Jacques André's 'Laura - or the sexual borders of need'.

Gesicles: Microvesicle "cookies" for transient information transfer between cells.

NK-cells have an impaired response to acute exercise and a lower expression of the inhibitory receptors KLRG1 and CD158a in humans with latent cytomegalovirus infection.

Immune responses to exercising in a cold environment.

ExoCarta 2012: database of exosomal proteins, RNA and lipids.

Prospective 12-month study of intrathecal baclofen therapy for poststroke spastic upper and lower extremity motor control and functional improvement.

Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam principles).

Recommendations for Mass Spectrometry Data Quality Metrics for Open Access Data (Corollary to the Amsterdam Principles).

Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam principles).

Meta-analysis of PECS with individuals with ASD: investigation of targeted versus non-targeted outcomes, participant characteristics, and implementation phase.

Treatment of Chronic Pain in Failed Back Surgery Patients with Spinal Cord Stimulation: a Review of Current Literature and Proposal for Future Investigation.

The impact of 6-month training preparation for an Ironman triathlon on the proportions of naïve, memory and senescent T cells in resting blood.

Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam principles).

Subthalamic deep brain stimulation with a constant-current device in Parkinson's disease: an open-label randomised controlled trial.

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes.

Proteomic Profiling of the Epithelial-Mesenchymal Transition Using 2D DIGE.