Robarts Research Institute,
Schulich School of Medicine and Dentistry,
Department of Biochemistry,
Robarts Research Institute, Schulich School of Medicine and Dentistry,
Department of Biochemistry, Schulich School of Medicine and Dentistry
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Clinical equivalence of proprietary and generic atorvastatin in lipid clinic patients.
The Canadian journal of cardiology Apr, 2013 | Pubmed ID: 22840301
Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib.
Drug design, development and therapy , 2012 | Pubmed ID: 23055695
Hypertriglyceridemia.
Nutrients Mar, 2013 | Pubmed ID: 23525082
The 2013 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension.
The Canadian journal of cardiology May, 2013 | Pubmed ID: 23541660
Sequencing: the next generation--what is the role of whole-exome sequencing in the diagnosis of familial cardiovascular diseases?
The Canadian journal of cardiology Feb, 2014 | Pubmed ID: 24461915
Exome sequencing identifies NFS1 deficiency in a novel Fe-S cluster disease, infantile mitochondrial complex II/III deficiency.
Molecular genetics & genomic medicine Jan, 2014 | Pubmed ID: 24498631
LipidSeq: a next-generation clinical resequencing panel for monogenic dyslipidemias.
Journal of lipid research Apr, 2014 | Pubmed ID: 24503134
The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management.
The lancet. Diabetes & endocrinology Aug, 2014 | Pubmed ID: 24731657
Inducing thyrotoxicosis in the liver to treat raised cholesterol.
The lancet. Diabetes & endocrinology Jun, 2014 | Pubmed ID: 24731675
Simple genetics language as source of miscommunication between genetics researchers and potential research participants in informed consent documents.
Public understanding of science (Bristol, England) Aug, 2015 | Pubmed ID: 24751688
The 2014 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension.
The Canadian journal of cardiology May, 2014 | Pubmed ID: 24786438
Exome sequencing: new insights into lipoprotein disorders.
Current cardiology reports Jul, 2014 | Pubmed ID: 24893940
Linkage analysis and exome sequencing identify a novel mutation in KCTD7 in patients with progressive myoclonus epilepsy with ataxia.
Epilepsia Sep, 2014 | Pubmed ID: 25060828
Is plant-based cardioprotection evidence-based?
The Canadian journal of cardiology Oct, 2014 | Pubmed ID: 25138482
G-protein estrogen receptor as a regulator of low-density lipoprotein cholesterol metabolism: cellular and population genetic studies.
Arteriosclerosis, thrombosis, and vascular biology Jan, 2015 | Pubmed ID: 25395619
Treatment of severe hypertriglyceridaemia--authors' reply.
The lancet. Diabetes & endocrinology Nov, 2014 | Pubmed ID: 25439460
The effect of infrequent low-dose rosuvastatin on the lipid profile.
The Canadian journal of cardiology Nov, 2014 | Pubmed ID: 25442436
Canadian Cardiovascular Society position statement on familial hypercholesterolemia.
The Canadian journal of cardiology Dec, 2014 | Pubmed ID: 25448461
Congenital sucrase-isomaltase deficiency: identification of a common Inuit founder mutation.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Feb, 2015 | Pubmed ID: 25452324
Doctor my eyes: a statin-cataract connection?
The Canadian journal of cardiology Dec, 2014 | Pubmed ID: 25475455
A novel LIPE nonsense mutation found using exome sequencing in siblings with late-onset familial partial lipodystrophy.
The Canadian journal of cardiology Dec, 2014 | Pubmed ID: 25475467
Hypertriglyceridemia in the genomic era: a new paradigm.
Endocrine reviews Feb, 2015 | Pubmed ID: 25554923
A novel MC4R mutation associated with childhood-onset obesity: A case report.
Paediatrics & child health Dec, 2014 | Pubmed ID: 25587224
A homozygous PMS2 founder mutation with an attenuated constitutional mismatch repair deficiency phenotype.
Journal of medical genetics May, 2015 | Pubmed ID: 25691505
HDL re-examined.
Current opinion in lipidology Apr, 2015 | Pubmed ID: 25692348
Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management.
European heart journal May, 2015 | Pubmed ID: 25694464
Chylomicronaemia--current diagnosis and future therapies.
Nature reviews. Endocrinology Jun, 2015 | Pubmed ID: 25732519
The new dyslipidemia guidelines: what is the debate?
The Canadian journal of cardiology May, 2015 | Pubmed ID: 25816728
Cardiology patient page. Statin intolerance.
Circulation Mar, 2015 | Pubmed ID: 25825402
The 2015 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension.
The Canadian journal of cardiology May, 2015 | Pubmed ID: 25936483
Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease.
Digestive diseases and sciences Dec, 2015 | Pubmed ID: 26160437
Incident Diabetes With Statins: Biology, Artifact, or Both?
The Canadian journal of cardiology Aug, 2015 | Pubmed ID: 26211707
Erratum to: Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease.
Digestive diseases and sciences Jan, 2016 | Pubmed ID: 26233551
Old gene, new phenotype: mutations in heparan sulfate synthesis enzyme, EXT2 leads to seizure and developmental disorder, no exostoses.
Journal of medical genetics Oct, 2015 | Pubmed ID: 26246518
Trial Watch: Antisenses working overtime in lipids.
Nature reviews. Endocrinology Oct, 2015 | Pubmed ID: 26303603
Severe Hypertriglyceridemia due to a novel p.Q240H mutation in the Lipoprotein Lipase gene.
Lipids in health and disease Sep, 2015 | Pubmed ID: 26337181
Nonstatin Low-Density Lipoprotein-Lowering Therapy and Cardiovascular Risk Reduction-Statement From ATVB Council.
Arteriosclerosis, thrombosis, and vascular biology Nov, 2015 | Pubmed ID: 26376908
Finding the Therapeutic Sweet Spot: Using Naturally Occurring Human Variants to Inform Drug Design.
Circulation. Cardiovascular genetics Oct, 2015 | Pubmed ID: 26487725
Combined hyperlipidemia: familial but not (usually) monogenic.
Current opinion in lipidology Apr, 2016 | Pubmed ID: 26709473
Novel therapeutics in hypertriglyceridemia.
Current opinion in lipidology Dec, 2015 | Pubmed ID: 26780002
Integrated Measure for Atherogenic Lipoproteins in the Modern Era: Risk Assessment Based on Apolipoprotein B.
Journal of the American College of Cardiology Jan, 2016 | Pubmed ID: 26791068
Statin Safety in Chinese: A Population-Based Study of Older Adults.
PloS one , 2016 | Pubmed ID: 26954681
Improving the Monitoring and Care of Patients With Familial Hypercholesterolemia.
Journal of the American College of Cardiology Mar, 2016 | Pubmed ID: 26988948
Pharmacogenetics of Lipid-Lowering Agents: Precision or Indecision Medicine?
Current atherosclerosis reports May, 2016 | Pubmed ID: 26993470
Applying Atherosclerotic Risk Prevention Guidelines to Elderly Patients: A Bridge Too Far?
The Canadian journal of cardiology May, 2016 | Pubmed ID: 27040095
Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension.
The Canadian journal of cardiology 05, 2016 | Pubmed ID: 27118291
Rare Genetic Variants and High-Density Lipoprotein: Marching to a Different Drum.
Arteriosclerosis, thrombosis, and vascular biology Jun, 2016 | Pubmed ID: 27127203
Proprietary Considerations in the Use of Cardiovascular Genetic Data.
The Canadian journal of cardiology Nov, 2016 | Pubmed ID: 27166076
Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution.
Atherosclerosis Jul, 2016 | Pubmed ID: 27182959
Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel.
The lancet. Diabetes & endocrinology Oct, 2016 | Pubmed ID: 27246162
Pharmacological Targeting of the Atherogenic Dyslipidemia Complex: The Next Frontier in CVD Prevention Beyond Lowering LDL Cholesterol.
Diabetes 07, 2016 | Pubmed ID: 27329952
Complying With the National Institutes of Health Guidelines and Principles for Rigor and Reproducibility: Refutations.
Arteriosclerosis, thrombosis, and vascular biology Jul, 2016 | Pubmed ID: 27335467
Whole-genome sequencing in French Canadians from Quebec.
Human genetics Nov, 2016 | Pubmed ID: 27376640
Multidimensional regulation of lipoprotein lipase: impact on biochemical and cardiovascular phenotypes.
Journal of lipid research 09, 2016 | Pubmed ID: 27412676
PCSK9: Regulation and Target for Drug Development for Dyslipidemia.
Annual review of pharmacology and toxicology Jan, 2017 | Pubmed ID: 27575716
Genetic Confirmation Rate in Clinically Suspected Maturity-Onset Diabetes of the Young.
Canadian journal of diabetes Dec, 2016 | Pubmed ID: 27634015
New oral agents for treating dyslipidemia.
Current opinion in lipidology Dec, 2016 | Pubmed ID: 27676196
Polygenic Versus Monogenic Causes of Hypercholesterolemia Ascertained Clinically.
Arteriosclerosis, thrombosis, and vascular biology Dec, 2016 | Pubmed ID: 27765764
Lomitapide for the treatment of hypertriglyceridemia.
Expert opinion on investigational drugs Dec, 2016 | Pubmed ID: 27785928
Seeking 'meta guidelines' for lipids.
European journal of preventive cardiology 01, 2017 | Pubmed ID: 27807189
PCSK9 inhibition and diabetes: turning to Mendel for clues.
The lancet. Diabetes & endocrinology 02, 2017 | Pubmed ID: 27939390
Identification and Characterization of Trimethylamine-N-oxide Uptake and Efflux Transporters.
Molecular pharmaceutics 01, 2017 | Pubmed ID: 27977217
KMT2D p.Gln3575His segregating in a family with autosomal dominant choanal atresia strengthens the Kabuki/CHARGE connection.
American journal of medical genetics. Part A Jan, 2017 | Pubmed ID: 27991736
The Ontario Neurodegenerative Disease Research Initiative (ONDRI).
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Mar, 2017 | Pubmed ID: 28003035
Clinical utility gene card for: Sitosterolaemia.
European journal of human genetics : EJHG 04, 2017 | Pubmed ID: 28029149
Genetics for the Identification of Lipid Targets Beyond PCSK9.
The Canadian journal of cardiology Mar, 2017 | Pubmed ID: 28109622
Variants in ANGPTL4 and the Risk of Coronary Artery Disease.
The New England journal of medicine 12, 2016 | Pubmed ID: 28112898
Functional foods and dietary supplements for the management of dyslipidaemia.
Nature reviews. Endocrinology 05, 2017 | Pubmed ID: 28133369
Complexity of mechanisms among human proprotein convertase subtilisin-kexin type 9 variants.
Current opinion in lipidology Apr, 2017 | Pubmed ID: 28157721
A Novel APOC2 Missense Mutation Causing Apolipoprotein C-II Deficiency With Severe Triglyceridemia and Pancreatitis.
The Journal of clinical endocrinology and metabolism May, 2017 | Pubmed ID: 28201738
Barriers to the Implementation of Lipoprotein Apheresis in Canada.
The Canadian journal of cardiology Mar, 2017 | Pubmed ID: 28232020
Genetics of Lipid and Lipoprotein Disorders and Traits.
Current genetic medicine reports , 2016 | Pubmed ID: 28286704
Treatment of Severe Hypercholesterolemia in a Woman With Advanced Primary Sclerosing Cholangitis.
JAMA cardiology May, 2017 | Pubmed ID: 28384790
Heterozygous familial hypercholesterolemia presenting as chylomicronemia syndrome.
Journal of clinical lipidology Jan - Feb, 2017 | Pubmed ID: 28391899
Insulin affordability.
The lancet. Diabetes & endocrinology May, 2017 | Pubmed ID: 28434485
Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults.
The Canadian journal of cardiology May, 2017 | Pubmed ID: 28449828
PCSK9 inhibitors: smooth sailing or a little turbulence ahead?
The lancet. Diabetes & endocrinology Jul, 2017 | Pubmed ID: 28483371
Recent advances in genetic testing for familial hypercholesterolemia.
Expert review of molecular diagnostics Jul, 2017 | Pubmed ID: 28524730
Genetics of Triglycerides and the Risk of Atherosclerosis.
Current atherosclerosis reports Jul, 2017 | Pubmed ID: 28534127
Clinical utility gene card for: Tangier disease.
European journal of human genetics : EJHG 06, 2017 | Pubmed ID: 28537273
Lomitapide for the treatment of hypercholesterolemia.
Expert opinion on pharmacotherapy Aug, 2017 | Pubmed ID: 28598687
Tools for Enhancement and Quality Improvement of Peer Assessment and Clinical Care in Endocrinology and Metabolism.
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry Jul, 2017 | Pubmed ID: 28739080
HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology.
Nature reviews. Cardiology Jan, 2018 | Pubmed ID: 28795686
Clinical Validation of Copy Number Variant Detection from Targeted Next-Generation Sequencing Panels.
The Journal of molecular diagnostics : JMD Nov, 2017 | Pubmed ID: 28818680
Polygenic determinants in extremes of high-density lipoprotein cholesterol.
Journal of lipid research Nov, 2017 | Pubmed ID: 28870971
Use of next-generation sequencing to detectgene copy number variation in familial hypercholesterolemia.
Journal of lipid research Nov, 2017 | Pubmed ID: 28874442
The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation.
Journal of lipid research Nov, 2017 | Pubmed ID: 28887372
Recent Advances in the Genetics of Atherothrombotic Disease and Its Determinants.
Arteriosclerosis, thrombosis, and vascular biology Oct, 2017 | Pubmed ID: 28954809
ARHGEF28 p.Lys280Metfs40Ter in an amyotrophic lateral sclerosis family with a C9orf72 expansion.
Neurology. Genetics Oct, 2017 | Pubmed ID: 28971145
Identification of a novel synaptic protein, TMTC3, involved in periventricular nodular heterotopia with intellectual disability and epilepsy.
Human molecular genetics Nov, 2017 | Pubmed ID: 28973161
Imputation of Baseline LDL Cholesterol Concentration in Patients with Familial Hypercholesterolemia on Statins or Ezetimibe.
Clinical chemistry Feb, 2018 | Pubmed ID: 29038147
OPTN p.Met468Arg and ATXN2 intermediate length polyQ extension in families with C9orf72 mediated amyotrophic lateral sclerosis and frontotemporal dementia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics Jan, 2018 | Pubmed ID: 29080331
Food Effect on Rosuvastatin Disposition and Low-Density Lipoprotein Cholesterol.
Clinical pharmacology and therapeutics Dec, 2017 | Pubmed ID: 29218707
The ONDRISeq panel: custom-designed next-generation sequencing of genes related to neurodegeneration.
NPJ genomic medicine , 2016 | Pubmed ID: 29263818
A Novel Generalized Lipodystrophy-Associated Progeroid Syndrome Due to Recurrent Heterozygous LMNA p.T10I Mutation.
The Journal of clinical endocrinology and metabolism Mar, 2018 | Pubmed ID: 29267953
Nutraceuticals in 2017: Nutraceuticals in endocrine disorders.
Nature reviews. Endocrinology Feb, 2018 | Pubmed ID: 29286047
Ezetimibe prescriptions in older Canadian adults after an acute myocardial infarction: a population-based cohort study.
Lipids in health and disease Jan, 2018 | Pubmed ID: 29310674
Learning From Patients With Ultrarare Conditions: Cholesterol Hoof Beats.
Journal of the American College of Cardiology Jan, 2018 | Pubmed ID: 29348021
Secondary causes of chylomicronemia: defining the underside of the iceberg.
Journal of internal medicine Apr, 2018 | Pubmed ID: 29392780
Whole genome sequencing in the clinic: empowerment or too much information?
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Feb, 2018 | Pubmed ID: 29431109
The Atherogenic Dyslipidemia Complex and Novel Approaches to Cardiovascular Disease Prevention in Diabetes.
The Canadian journal of cardiology Dec, 2017 | Pubmed ID: 29459241
Fatty liver in a non-obese patient.
Paediatrics & child health May, 2017 | Pubmed ID: 29479178
Complex genetic architecture in severe hypobetalipoproteinemia.
Lipids in health and disease Mar, 2018 | Pubmed ID: 29540175
Allison A. Dilliott1,2,
Sali M.K. Farhan3,
Mahdi Ghani4,
Christine Sato4,
Eric Liang5,
Ming Zhang4,
Adam D. McIntyre1,
Henian Cao1,
Lemuel Racacho6,7,
John F. Robinson1,
Michael J. Strong1,8,
Mario Masellis9,10,
Dennis E. Bulman6,7,
Ekaterina Rogaeva4,
Anthony Lang10,11,
Carmela Tartaglia4,10,
Elizabeth Finger12,13,
Lorne Zinman9,
John Turnbull14,
Morris Freedman10,15,
Rick Swartz9,
Sandra E. Black9,16,
Robert A. Hegele1,2
1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University,
2Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University,
3Analytic and Translational Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Massachusetts General Hospital, Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard,
4Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto,
5School of Medicine, Faculty of Health Sciences, Queen's University,
6Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa,
7CHEO Research Institute, Faculty of Medicine, University of Ottawa,
8Department of Clinical Neurological Sciences, Western University,
9Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto,
10Division of Neurology, Department of Medicine, University of Toronto,
11Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital,
12Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University,
13Parkwood Institute, St. Joseph's Health Care,
14Department of Medicine, Division of Neurology, McMaster University,
15Division of Neurology, Department of Medicine, Baycrest Health Sciences,
16Canadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Science Centre, University of Toronto
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