Rudolf Jaenisch

Chromosomal silencing and localization are mediated by different domains of Xist RNA.

Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals.

Flp recombinase regulated lacZ expression at the ROSA26 locus.

Monoclonal mice generated by nuclear transfer from mature B and T donor cells.

Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality.

Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy.

Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation.

Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.

Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei.

Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist.

Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain.

X-chromosome inactivation during spermatogenesis is regulated by an Xist/Tsix-independent mechanism in the mouse.

Nuclear transplantation: lessons from frogs and mice.

Stroke damage in mice after knocking the neutrophin-4 gene into the brain-derived neurotrophic factor locus.

Rapid generation of inducible mouse mutants.

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

HIF-1alpha is essential for myeloid cell-mediated inflammation.

Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization.

Chromosomal instability and tumors promoted by DNA hypomethylation.

Induction of tumors in mice by genomic hypomethylation.

Stem cells. Setting standards for human embryonic stem cells.

Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics.

Nuclear transplantation, embryonic stem cells, and the potential for cell therapy.

Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2.

Differentiation of F1 embryonic stem cells into viable male and female mice by tetraploid embryo complementation.

Mice cloned from olfactory sensory neurons.

Micromanipulating dosage compensation: understanding X-chromosome inactivation through nuclear transplantation.

Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis.

Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice.

Nuclear transplantation, embryonic stem cells and the potential for cell therapy.

Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase.

Cre-lox-regulated conditional RNA interference from transgenes.

Reprogramming of a melanoma genome by nuclear transplantation.

Nuclear cloning of embryonal carcinoma cells.

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.

At most three ES cells contribute to the somatic lineages of chimeric mice and of mice produced by ES-tetraploid complementation.

Sixteenth Annual Pezcoller Symposium: stem cells and epigenesis in cancer.

Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome.

Human cloning - the science and ethics of nuclear transplantation.

X chromosome choice occurs independently of asynchronous replication timing.

Direct in vivo VH to JH rearrangement violating the 12/23 rule.

DNA CpG hypomethylation induces heterochromatin reorganization involving the histone variant macroH2A.

Normal eye-specific patterning of retinal inputs to murine subcortical visual nuclei in the absence of brain-derived neurotrophic factor.

Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.

Characterization of a highly variable eutherian microRNA gene.

Nuclear cloning, embryonic stem cells, and transplantation therapy.

Nuclear cloning, epigenetic reprogramming and cellular differentiation.

Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome.

Core transcriptional regulatory circuitry in human embryonic stem cells.

Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.

Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice.

Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis.

Global loss of imprinting leads to widespread tumorigenesis in adult mice.

Generation of nuclear transfer-derived pluripotent ES cells from cloned Cdx2-deficient blastocysts.

Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells.

Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice.

ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable.

The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression.

Politically correct human embryonic stem cells?

Suppression of intestinal neoplasia by deletion of Dnmt3b.

Polycomb complexes repress developmental regulators in murine embryonic stem cells.

Control of developmental regulators by Polycomb in human embryonic stem cells.

A bivalent chromatin structure marks key developmental genes in embryonic stem cells.

NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis.

Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus.

Nuclear reprogramming and pluripotency.

Mammalian nuclear transfer.

Molecular control of pluripotency.

Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation.

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.

On the cloning of animals from terminally differentiated cells.

Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2.

Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways.

Commentary: isolated stem cells--patentable as cultural artifacts?

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis.

Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan.

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.

Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes.

A chromatin landmark and transcription initiation at most promoters in human cells.

Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells.

DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons.

YAP1 increases organ size and expands undifferentiated progenitor cells.

Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing.

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.

Oct4 expression is not required for mouse somatic stem cell self-renewal.

The pluripotency regulator Oct4: a role in somatic stem cells?

Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming.

Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters.

Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.

Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer.

New advances in iPS cell research do not obviate the need for human embryonic stem cells.

c-Myc is dispensable for direct reprogramming of mouse fibroblasts.

Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells.

Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation.

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.

Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency.

Dissecting direct reprogramming through integrative genomic analysis.

Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development.

Somatic cell nuclear transfer and derivation of embryonic stem cells in the mouse.

A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types.

Genome-scale DNA methylation maps of pluripotent and differentiated cells.

Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase.

Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression.

Wnt signaling promotes reprogramming of somatic cells to pluripotency.

Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells.

Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET.

Interview with Rudolf Jaenisch, M.D.

Nanoparticles for gene transfer to human embryonic stem cell colonies.

A drug-inducible system for direct reprogramming of human somatic cells to pluripotency.

Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations.

H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment.

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells.

Derivation and manipulation of murine embryonic stem cells.

Reprogramming of murine and human somatic cells using a single polycistronic vector.

Celebrating 10 years of hESC lines: an interview with Rudolf Jaenisch.

Microfluidic control of cell pairing and fusion.

Transgenic mice with defined combinations of drug-inducible reprogramming factors.

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals.

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice.

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.

Broader implications of defining standards for the pluripotency of iPSCs.

Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.

Epigenetic hierarchy governing Nestin expression.

HDAC2 negatively regulates memory formation and synaptic plasticity.

Metastable pluripotent states in NOD-mouse-derived ESCs.

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.

Cardiac myocytes derived from murine reprogrammed fibroblasts: intact hormonal regulation, cardiac ion channel expression and development of contractility.

Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases.

Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro.

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

Direct cell reprogramming is a stochastic process amenable to acceleration.

Technical challenges in using human induced pluripotent stem cells to model disease.

Single-gene transgenic mouse strains for reprogramming adult somatic cells.

TCR beta feedback signals inhibit the coupling of recombinationally accessible V beta 14 segments with DJ beta complexes.

Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells.

Generation of iPSCs from cultured human malignant cells.

Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT.

Two-step imprinted X inactivation: repeat versus genic silencing in the mouse.

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells. 1990.

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs.

Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.

Reprogramming of human peripheral blood cells to induced pluripotent stem cells.

Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells.

Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes.

Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells.

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.

T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell.

Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues.

Histone H3K27ac separates active from poised enhancers and predicts developmental state.

Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer.

Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells.

Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors.

A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells.

De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state.

Genetic engineering of human pluripotent cells using TALE nucleases.

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.

Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.

Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects.

Transgene excision has no impact on in vivo integration of human iPS derived neural precursors.

Blimp1 expression predicts embryonic stem cell development in vitro.

Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.

Functional integration of dopaminergic neurons directly converted from mouse fibroblasts.

Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions.

Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells.