Ralf Bartenschlager

New insights into structure and replication of the hepatitis C virus and clinical implications.

Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome.

Assembly of infectious hepatitis C virus particles.

Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment.

NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes.

Hepatitis C virus and host cell lipids: an intimate connection.

Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I).

Mouse hepatic cells support assembly of infectious hepatitis C virus particles.

Exploitation of cellular pathways by Dengue virus.

Normalizing for individual cell population context in the analysis of high-content cellular screens.

New targets for antiviral therapy of chronic hepatitis C.

Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.

Persistence of HCV in quiescent hepatic cells under conditions of an interferon-induced antiviral response.

Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection.

Promotion of hepatocellular carcinoma by hepatitis C virus.

Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B.

The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection.

Evidence for novel hepaciviruses in rodents.

Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment.

Interferon-stimulated genes and their role in controlling hepatitis C virus.

Replication vesicles are load- and choke-points in the hepatitis C virus lifecycle.

Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines.

Thiazolidinone-peptide hybrids as dengue virus protease inhibitors with antiviral activity in cell culture.

On the history of hepatitis C virus cell culture systems.

Inhibition of HCV replication by cyclophilin antagonists is linked to replication fitness and occurs by inhibition of membranous web formation.

Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 Nef.

Strategies to inhibit entry of HBV and HDV into hepatocytes.

Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication.

Membranous replication factories induced by plus-strand RNA viruses.

Characterization of the mode of action of a potent dengue virus capsid inhibitor.

Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region.

The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production.

Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins.

Wheat germ cell-free expression: Two detergents with a low critical micelle concentration allow for production of soluble HCV membrane proteins.

Novel dengue virus NS2B/NS3 protease inhibitors.

Hepatitis C virus RNA replication and assembly: living on the fat of the land.

Going full circle: validation of P-body dispersion in hepatitis C virus-infected patients.

Identification of HNRNPK as regulator of hepatitis C virus particle production.

Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody.

Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A.

A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication.

Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.

Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62.

Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity.

NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication.

Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys.

Structural and Functional Properties of the Hepatitis C Virus p7 Viroporin.

Functional expression, purification, characterization, and membrane reconstitution of non-structural protein 2 from hepatitis C virus.

Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors.

Apolipoprotein E Mediates Evasion From Hepatitis C Virus Neutralizing Antibodies.

Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue.

Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production via Interaction with the Structural Proteins.

Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor.

Paradoxical role of antibodies in dengue virus infections: considerations for prophylactic vaccine development.

Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus.

Viral Infection at High Magnification: 3D Electron Microscopy Methods to Analyze the Architecture of Infected Cells.

Coordination of Hepatitis C Virus Assembly by Distinct Regulatory Regions in Nonstructural Protein 5A.

Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family.

Flaviviridae Replication Organelles: Oh, What a Tangled Web We Weave.

Correlative light and electron microscopy methods for the study of virus-cell interactions.

Geno2pheno[HCV] - A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents.

Cell-free expression, purification, and membrane reconstitution for NMR studies of the nonstructural protein 4B from hepatitis C virus.

Reovirus intermediate subviral particles constitute a strategy to infect intestinal epithelial cells by exploiting TGF-β dependent pro-survival signaling.

Investigation of NS3 Protease Resistance-Associated Variants and Phenotypes for the Prediction of Treatment Response to HCV Triple Therapy.

A Slow Maturation Process Renders Hepatitis B Virus Infectious.

Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly.

Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin.

Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses.

TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus.

Hepatitis C Virus-From Discovery to Cure: The 2016 Lasker-DeBakey Clinical Medical Research Award.

The quest for host targets to combat dengue virus infections.

Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology.

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses.

Editorial: An expanded view of viruses.

Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening.

Novel nucleoside analogues targeting HCV replication through an NS5A-dependent inhibition mechanism.

Ultrastructural Characterization of Zika Virus Replication Factories.

Immune protection against reinfection with nonprimate hepacivirus.

A Novel Inhibitor IDPP Interferes with Entry and Egress of HCV by Targeting Glycoprotein E1 in a Genotype-Specific Manner.

Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication.

Erratum for Roth et al., "Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses".

Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity.

Genome packaging of reovirus is mediated by the scaffolding property of the microtubule network.

Host-directed therapies for bacterial and viral infections.

Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis.

Optimization of Substrate-Analogue Furin Inhibitors.

Membrane alterations induced by nonstructural proteins of human norovirus.

Glycine Zipper Motifs in Hepatitis C Virus Nonstructural Protein 4B Are Required for the Establishment of Viral Replication Organelles.

HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon.

Rewiring cellular networks by members of the Flaviviridae family.

Structural Studies of Self-Assembled Subviral Particles: Combining Cell-Free Expression with 110 kHz MAS NMR Spectroscopy.

Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies.

HCV modifies EGF signalling and upregulates production of CXCR2 ligands: Role in inflammation and antiviral immune response.

Semen inhibits Zika virus infection of cells and tissues from the anogenital region.

A Reverse Genetics System for Zika Virus Based on a Simple Molecular Cloning Strategy.

Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro.