Paul Knoepfler

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation.

Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential.

HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations.

Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation.

Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes.

Myc influences global chromatin structure.

N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development.

N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth.

Activities of N-Myc in the developing limb link control of skeletal size with digit separation.

Myc goes global: new tricks for an old oncogene.

Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.

N-myc coordinates retinal growth with eye size during mouse development.

Stem cells on the brain.

Why myc? An unexpected ingredient in the stem cell cocktail.

Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity.

N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor.

Journal club. A cell biologist looks at the risk and promise of a new insight into stem cells and cancer.

Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine.

N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b.

Acting locally and globally: Myc's ever-expanding roles on chromatin.

Division and apoptosis of E2f-deficient retinal progenitors.

The death of MyMouseHouse: lessons for systems for the efficient management of mouse colonies.

Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex.

myc maintains embryonic stem cell pluripotency and self-renewal.

c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain.

c- and N-myc regulate neural precursor cell fate, cell cycle, and metabolism to direct cerebellar development.

Arrestin' the hedgehog: Shh limits its own signaling via β-Arrestin1.

N-myc controls proliferation, morphogenesis, and patterning of the inner ear.

My year as a stem-cell blogger.

Inducing iPSCs to escape the dish.

Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells.