Radboud Institute for Health Sciences,
Department of Nephrology,
Radboud Institute for Health Sciences, Department of Nephrology
Jack Wetzels has not added Biography.
If you are Jack Wetzels and would like to personalize this page please email our Author Liaison for assistance.
Nurse practitioner care improves renal outcome in patients with CKD.
Journal of the American Society of Nephrology : JASN Feb, 2014 | Pubmed ID: 24158983
Long-term treatment with tenofovir: prevalence of kidney tubular dysfunction and its association with tenofovir plasma concentration.
Antiviral therapy , 2014 | Pubmed ID: 24584104
Phospholipase A2 receptor antibodies in membranous nephropathy: unresolved issues.
Journal of the American Society of Nephrology : JASN Jun, 2014 | Pubmed ID: 24610931
Glucose specifically regulates TRPC6 expression in the podocyte in an AngII-dependent manner.
The American journal of pathology Jun, 2014 | Pubmed ID: 24731445
TRPC6 single nucleotide polymorphisms and progression of idiopathic membranous nephropathy.
PloS one , 2014 | Pubmed ID: 25019165
Novel aspects of atypical haemolytic uraemic syndrome and the role of eculizumab.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Sep, 2014 | Pubmed ID: 25165180
Permeability factors in idiopathic nephrotic syndrome: historical perspectives and lessons for the future.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Dec, 2014 | Pubmed ID: 25416821
Urinary biomarkers after donor nephrectomy.
Transplant international : official journal of the European Society for Organ Transplantation May, 2015 | Pubmed ID: 25581388
Impact of fractional phosphate excretion on the relation of FGF23 with outcome in CKD patients.
Journal of nephrology Aug, 2015 | Pubmed ID: 25700931
Individualizing pharmacotherapy in patients with renal impairment: the validity of the Modification of Diet in Renal Disease formula in specific patient populations with a glomerular filtration rate below 60 ml/min. A systematic review.
PloS one , 2015 | Pubmed ID: 25741695
Kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin as prognostic markers in idiopathic membranous nephropathy.
Annals of clinical biochemistry Jan, 2016 | Pubmed ID: 25762211
Serum anti-PLA2R antibodies can be initially absent in idiopathic membranous nephropathy: seroconversion after prolonged follow-up.
Kidney international Jun, 2015 | Pubmed ID: 26024039
Sensitive, reliable and easy-performed laboratory monitoring of eculizumab therapy in atypical hemolytic uremic syndrome.
Clinical immunology (Orlando, Fla.) Oct, 2015 | Pubmed ID: 26111482
Therapy: Maintenance of steroid-free remission in nephrotic syndrome.
Nature reviews. Nephrology Oct, 2015 | Pubmed ID: 26195145
Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology.
Toxicology in vitro : an international journal published in association with BIBRA Oct, 2015 | Pubmed ID: 26216510
Estimation of total kidney volume in autosomal dominant polycystic kidney disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation Nov, 2015 | Pubmed ID: 26235803
Rituximab can induce remission of nephrotic syndrome in the absence of peripheral B-cells.
Nephrology (Carlton, Vic.) Sep, 2015 | Pubmed ID: 26278122
Increased expression of lysosome membrane protein 2 in glomeruli of patients with idiopathic membranous nephropathy.
Proteomics Nov, 2015 | Pubmed ID: 26304790
Hepatocyte Nuclear Factor 1β-Associated Kidney Disease: More than Renal Cysts and Diabetes.
Journal of the American Society of Nephrology : JASN Feb, 2016 | Pubmed ID: 26319241
Differential Expression of Specific Dermatan Sulfate Domains in Renal Pathology.
PloS one , 2015 | Pubmed ID: 26322947
Prevalence of Apparent Therapy-Resistant Hypertension and Its Effect on Outcome in Patients With Chronic Kidney Disease.
Hypertension (Dallas, Tex. : 1979) Nov, 2015 | Pubmed ID: 26351024
Kidney Weight in Living and Postmortal Kidney Donation.
Transplantation Jan, 2016 | Pubmed ID: 26469985
Synthetic ACTH in High Risk Patients with Idiopathic Membranous Nephropathy: A Prospective, Open Label Cohort Study.
PloS one , 2015 | Pubmed ID: 26562836
Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus.
Journal of the American Society of Nephrology : JASN Jul, 2016 | Pubmed ID: 26574046
Renal Handling of Circulating and Renal-Synthesized Hepcidin and Its Protective Effects against Hemoglobin-Mediated Kidney Injury.
Journal of the American Society of Nephrology : JASN 09, 2016 | Pubmed ID: 26825531
Thiazide Responsiveness Testing in Patients With Renal Magnesium Wasting and Correlation With Genetic Analysis: A Diagnostic Test Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation 07, 2016 | Pubmed ID: 26830254
Central arteriovenous anastomosis and hypertension.
Lancet (London, England) Nov, 2015 | Pubmed ID: 26843305
1,25-Vitamin D3 Deficiency Induces Albuminuria.
The American journal of pathology Apr, 2016 | Pubmed ID: 26851346
Quality of chronic kidney disease management in primary care: a retrospective study.
Scandinavian journal of primary health care , 2016 | Pubmed ID: 26853071
Abdominal aortic calcification in patients with CKD.
Journal of nephrology Feb, 2017 | Pubmed ID: 27003153
Should aspirin be used for primary prevention of thrombotic events in patients with membranous nephropathy?
Kidney international May, 2016 | Pubmed ID: 27083274
Kidney Dysfunction Increases Mortality and Incident Events after Young Stroke: The FUTURE Study.
Cerebrovascular diseases (Basel, Switzerland) , 2016 | Pubmed ID: 27173119
Pharmacological treatment of primary membranous nephropathy in 2016.
Expert review of clinical pharmacology Nov, 2016 | Pubmed ID: 27535699
Drug therapy management in patients with renal impairment: how to use creatinine-based formulas in clinical practice.
European journal of clinical pharmacology Dec, 2016 | Pubmed ID: 27568310
Minimal change disease and idiopathic FSGS: manifestations of the same disease.
Nature reviews. Nephrology Dec, 2016 | Pubmed ID: 27748392
Hepatic Cyst Infection During Use of the Somatostatin Analog Lanreotide in Autosomal Dominant Polycystic Kidney Disease: An Interim Analysis of the Randomized Open-Label Multicenter DIPAK-1 Study.
Drug safety 02, 2017 | Pubmed ID: 27995519
Lifetime risk of renal replacement therapy in Europe: a population-based study using data from the ERA-EDTA Registry.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 02, 2017 | Pubmed ID: 28031344
Uremic Solutes in Chronic Kidney Disease and Their Role in Progression.
PloS one , 2016 | Pubmed ID: 28033375
Copeptin, a surrogate marker for arginine vasopressin, is associated with disease severity and progression in IgA nephropathy patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 01, 2017 | Pubmed ID: 28057871
The Clinical Course of Minimal Change Nephrotic Syndrome With Onset in Adulthood or Late Adolescence: A Case Series.
American journal of kidney diseases : the official journal of the National Kidney Foundation May, 2017 | Pubmed ID: 28089478
Glomerular disease in 2016: New advances in the treatment of glomerular disease.
Nature reviews. Nephrology 01, 2017 | Pubmed ID: 28100906
Web-based consultation between general practitioners and nephrologists: a cluster randomized controlled trial.
Family practice 08, 2017 | Pubmed ID: 28158576
Adherence to chronic kidney disease guidelines in primary care patients is associated with comorbidity.
Family practice 08, 2017 | Pubmed ID: 28207923
Development and Pretesting of a Questionnaire to Assess Patient Experiences and Satisfaction with Medications (PESaM Questionnaire).
The patient Oct, 2017 | Pubmed ID: 28357591
Cost-effectiveness of eculizumab treatment after kidney transplantation in patients with atypical haemolytic uraemic syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 01, 2017 | Pubmed ID: 28391343
Clinical Relevance of Differences in Glomerular Filtration Rate Estimations in Frail Older People by Creatinine- vs. Cystatin C-Based Formulae.
Drugs & aging 06, 2017 | Pubmed ID: 28405944
Safety of Rituximab Compared with Steroids and Cyclophosphamide for Idiopathic Membranous Nephropathy.
Journal of the American Society of Nephrology : JASN Sep, 2017 | Pubmed ID: 28487395
Urinary Excretion of α-Microglobulin Does Not Predict Graft Loss in Stable Kidney Transplant Recipients.
American journal of kidney diseases : the official journal of the National Kidney Foundation 07, 2017 | Pubmed ID: 28501240
Lithium-induced NDI: acetazolamide reduces polyuria but does not improve urine concentrating ability.
American journal of physiology. Renal physiology 09, 2017 | Pubmed ID: 28615247
Use of the Furosemide Fludrocortisone Test to Clinically Assess Distal Tubular Acidification.
American journal of kidney diseases : the official journal of the National Kidney Foundation 10, 2017 | Pubmed ID: 28634085
Disposition and clinical implications of protein-bound uremic toxins.
Clinical science (London, England : 1979) Jul, 2017 | Pubmed ID: 28667064
A Novel Hypokalemic-Alkalotic Salt-Losing Tubulopathy in Patients with Mutations.
Journal of the American Society of Nephrology : JASN Oct, 2017 | Pubmed ID: 28674042
Living Donor Kidney Transplantation in Atypical Hemolytic Uremic Syndrome: A Case Series.
American journal of kidney diseases : the official journal of the National Kidney Foundation Dec, 2017 | Pubmed ID: 28821363
The Association of Combined Total Kidney and Liver Volume with Pain and Gastrointestinal Symptoms in Patients with Later Stage Autosomal Dominant Polycystic Kidney Disease.
American journal of nephrology , 2017 | Pubmed ID: 28881341
Renal physiology: Prostaglandins in thiazide-induced hyponatraemia: do they hold water?
Nature reviews. Nephrology 11, 2017 | Pubmed ID: 28944774
Safety and effectiveness of restrictive eculizumab treatment in atypical haemolytic uremic syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 04, 2018 | Pubmed ID: 29106598
Reference values of renal tubular function tests are dependent on age and kidney function.
Physiological reports Dec, 2017 | Pubmed ID: 29212860
CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis.
Kidney international 03, 2018 | Pubmed ID: 29276101
Interleukin-6 is essential for glomerular immunoglobulin A deposition and the development of renal pathology in Cd37-deficient mice.
Kidney international 06, 2018 | Pubmed ID: 29551516
Immunological remission in PLA2R-antibody-associated membranous nephropathy: cyclophosphamide versus rituximab.
Kidney international 04, 2018 | Pubmed ID: 29571438
Effects of sildenafil, metformin, and simvastatin on ADH-independent urine concentration in healthy volunteers.
Physiological reports 04, 2018 | Pubmed ID: 29611351
General practitioners' perspectives on management of early-stage chronic kidney disease: a focus group study.
BMC family practice 06, 2018 | Pubmed ID: 29875016
The Calcium-Dependent Protease Calpain-1 Links TRPC6 Activity to Podocyte Injury.
Journal of the American Society of Nephrology : JASN 08, 2018 | Pubmed ID: 29954830
What Patients with Mild-to-Moderate Kidney Disease Know, Think, and Feel about Their Disease: An In-Depth Interview Study.
Journal of the American Board of Family Medicine : JABFM Jul-Aug, 2018 | Pubmed ID: 29986983
Benefit of Eculizumab Compared to Standard of Care Still Unproven in C3 Glomerulopathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation 12, 2018 | Pubmed ID: 30236630
Nephrotic Syndrome With Mutations in NPHS2: The Role of R229Q and Implications for Genetic Counseling.
American journal of kidney diseases : the official journal of the National Kidney Foundation 03, 2019 | Pubmed ID: 30241959
The authors reply.
Kidney international 10, 2018 | Pubmed ID: 30243321
Urine Acidification After Ammonium Chloride.
American journal of kidney diseases : the official journal of the National Kidney Foundation 12, 2018 | Pubmed ID: 30297083
The Use of N-of-1 Trials to Individualize Treatment in Patients With Renal Magnesium Wasting.
American journal of kidney diseases : the official journal of the National Kidney Foundation 02, 2019 | Pubmed ID: 30318133
Eculizumab in atypical hemolytic uremic syndrome: strategies toward restrictive use.
Pediatric nephrology (Berlin, Germany) 11, 2019 | Pubmed ID: 30402748
Is there long-term value of pathology scoring in immunoglobulin A nephropathy? A validation study of the Oxford Classification for IgA Nephropathy (VALIGA) update.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Jun, 2020 | Pubmed ID: 30418652
Effect of Lanreotide on Kidney Function in Patients With Autosomal Dominant Polycystic Kidney Disease: The DIPAK 1 Randomized Clinical Trial.
JAMA 11, 2018 | Pubmed ID: 30422235
Antibodies Against M-Type Phospholipase Receptor and Prediction of Outcome in Membranous Nephropathy: We are Not There Yet.
American journal of nephrology , 2018 | Pubmed ID: 30472711
Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies.
The lancet. Diabetes & endocrinology 02, 2019 | Pubmed ID: 30635225
Correction to: Eculizumab in atypical hemolytic uremic syndrome: strategies toward restrictive use.
Pediatric nephrology (Berlin, Germany) Apr, 2019 | Pubmed ID: 30645679
Management and treatment of glomerular diseases (part 1): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
Kidney international 02, 2019 | Pubmed ID: 30665568
Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab.
Clinical pharmacokinetics 07, 2019 | Pubmed ID: 30758736
Novel ELISA for thrombospondin type 1 domain-containing 7A autoantibodies in membranous nephropathy.
Kidney international 03, 2019 | Pubmed ID: 30784662
Placental passage of eculizumab and complement blockade in a newborn.
Kidney international 04, 2019 | Pubmed ID: 30904074
Lanreotide Reduces Liver Growth In Patients With Autosomal Dominant Polycystic Liver and Kidney Disease.
Gastroenterology Apr, 2019 | Pubmed ID: 31022403
The bias between different albumin assays may affect clinical decision-making.
Kidney international 06, 2019 | Pubmed ID: 31053386
Predicting kidney failure from longitudinal kidney function trajectory: A comparison of models.
PloS one , 2019 | Pubmed ID: 31071186
The authors reply.
Kidney international 07, 2019 | Pubmed ID: 31229039
Genetic Identification of Two Novel Loci Associated with Steroid-Sensitive Nephrotic Syndrome.
Journal of the American Society of Nephrology : JASN 08, 2019 | Pubmed ID: 31263063
Performance of GFR Slope as a Surrogate End Point for Kidney Disease Progression in Clinical Trials: A Statistical Simulation.
Journal of the American Society of Nephrology : JASN 09, 2019 | Pubmed ID: 31292198
Evaluating Glomerular Filtration Rate Slope as a Surrogate End Point for ESKD in Clinical Trials: An Individual Participant Meta-Analysis of Observational Data.
Journal of the American Society of Nephrology : JASN 09, 2019 | Pubmed ID: 31292199
Unraveling Hepcidin Plasma Protein Binding: Evidence from Peritoneal Equilibration Testing.
Pharmaceuticals (Basel, Switzerland) Aug, 2019 | Pubmed ID: 31450766
Complement inhibitors are not useful in secondary hemolytic uremic syndromes.
Kidney international 10, 2019 | Pubmed ID: 31543154
The multifaceted role of iron in renal health and disease.
Nature reviews. Nephrology 02, 2020 | Pubmed ID: 31554933
The anti-PLA2R antibody in membranous nephropathy: what we know and what remains a decade after its discovery.
Kidney international 12, 2019 | Pubmed ID: 31611068
Five non-mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes phenotype adult patients with m.3243A>G mutation after kidney transplantation: follow-up and review of the literature.
Clinical kidney journal Dec, 2019 | Pubmed ID: 31807297
The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases.
Kidney international Apr, 2020 | Pubmed ID: 32059999
The complement component C5 is not responsible for the alternative pathway activity in rabbit erythrocyte hemolytic assays during eculizumab treatment.
Cellular & molecular immunology Jun, 2020 | Pubmed ID: 32210393
The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis.
Nature communications 03, 2020 | Pubmed ID: 32231244
Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis.
Scientific reports May, 2020 | Pubmed ID: 32444668
Treatment-resistant nephrotic syndrome in dense deposit disease: complement-mediated glomerular capillary wall injury?
Pediatric nephrology (Berlin, Germany) Sep, 2020 | Pubmed ID: 32447506
Salt, but not protein intake, is associated with accelerated disease progression in autosomal dominant polycystic kidney disease.
Kidney international Jun, 2020 | Pubmed ID: 32534051
Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis.
Journal of the American Society of Nephrology : JASN Aug, 2020 | Pubmed ID: 32561683
Conversion of Urine Protein-Creatinine Ratio or Urine Dipstick Protein to Urine Albumin-Creatinine Ratio for Use in Chronic Kidney Disease Screening and Prognosis: An Individual Participant-Based Meta-analysis.
Annals of internal medicine Jul, 2020 | Pubmed ID: 32658569
Standardized reporting of monoclonal immunoglobulin-associated renal diseases: recommendations from a Mayo Clinic/Renal Pathology Society Working Group.
Kidney international Aug, 2020 | Pubmed ID: 32709293
Jennifer Eymael1,
Laura Miesen1,
Fieke Mooren1,
Jitske Jansen1,2,
Jack Wetzels3,
Johan van der Vlag4,
Bart Smeets1
1Radboud Institute for Molecular Life Sciences, Department of Pathology, Radboud University Medical Center,
2Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Department of Paediatric Nephrology, Radboud University Medical Center,
3Radboud Institute for Health Sciences, Department of Nephrology, Radboud University Medical Center,
4Radboud Institute for Molecular Life Sciences, Department of Nephrology, Radboud University Medical Center
ACERCA DE JoVE
Copyright © 2024 MyJoVE Corporation. Todos los derechos reservados