Jerrold R. Turner

Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection.

MMR vaccination, ileal lymphoid nodular hyperplasia, and pervasive develop-mental disorder.

High-molecular-weight polyethylene glycol prevents lethal sepsis due to intestinal Pseudomonas aeruginosa.

A porous defense: the leaky epithelial barrier in intestinal disease.

Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy.

Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport.

A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability.

Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation.

Components of intestinal epithelial hypoxia activate the virulence circuitry of Pseudomonas.

Mouse model of enteropathogenic Escherichia coli infection.

Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.

Comparative analysis of the in vitro prosecretory effects of balsalazide, sulfasalazine, olsalazine, and mesalamine in rabbit distal ileum.

Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.

The critical role of LIGHT in promoting intestinal inflammation and Crohn's disease.

Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis.

Recognition of host immune activation by Pseudomonas aeruginosa.

Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane.

Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa.

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.

CD18 is required for optimal development and function of CD4+CD25+ T regulatory cells.

Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease.

Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed.

Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure.

Identification of multi-drug resistant Pseudomonas aeruginosa clinical isolates that are highly disruptive to the intestinal epithelial barrier.

MAPKAPK-2 is a critical signaling intermediate in NHE3 activation following Na+-glucose cotransport.

Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter.

Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa.

Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo.

IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction.

Surveillance of dysplasia in inflammatory bowel disease: The gastroenterologist-pathologist partnership.

Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application.

Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis.

Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli.

Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa.

MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties.

LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms.

Rho activation regulates CXCL12 chemokine stimulated actin rearrangement and restitution in model intestinal epithelia.

Anti-inflammatory effects of phosphatidylcholine.

Stimulus-induced reorganization of tight junction structure: the role of membrane traffic.

Function, expression, and characterization of the serotonin transporter in the native human intestine.

Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5.

Modulation of ileal bile acid transporter (ASBT) activity by depletion of plasma membrane cholesterol: association with lipid rafts.

A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age.

SGLT-1-mediated glucose uptake protects human intestinal epithelial cells against Giardia duodenalis-induced apoptosis.

Structure-function aspects of PstS in multi-drug-resistant Pseudomonas aeruginosa.

The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state.

Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium.

Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells.

Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells.

Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation.

Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation.

Intercellular junctions: actin the PARt.

Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions.

Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis.

PKC eta regulates occludin phosphorylation and epithelial tight junction integrity.

Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions.

Epithelium, tear down this wall!

Evaluation of diffusion-weighted MR imaging for detection of bowel inflammation in patients with Crohn's disease.

Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium.

No static at all.

The tight junction in inflammatory disease: communication breakdown.

Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation.

Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression.

Alternative promoter and GATA5 transcripts in mouse.

Intestinal mucosal barrier function in health and disease.

Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway.

Mechanisms and functional implications of intestinal barrier defects.

Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation.

Outcome after surveillance of low-grade and indefinite dysplasia in patients with ulcerative colitis.

Cell death in the colonic epithelium during inflammatory bowel diseases: CD95/Fas and beyond.

Epithelial barriers in homeostasis and disease.

Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions.

Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity.

Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo.

Menetrier's disease therapy: rebooting mucosal signaling.

MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function.

CD95 promotes tumour growth.

Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis.

Time-resolved luminescence resonance energy transfer imaging of protein-protein interactions in living cells.

Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments.

Glucose-induced ERM protein activation and translocation regulates insulin secretion.

Tight junction pore and leak pathways: a dynamic duo.

D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent process.

Enteropathogenic E. coli non-LEE encoded effectors NleH1 and NleH2 attenuate NF-κB activation.

Cingulin and paracingulin show similar dynamic behaviour, but are recruited independently to junctions.

The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding.

Crystallization and preliminary X-ray analysis of the human long myosin light-chain kinase 1-specific domain IgCAM3.

Good fences make good neighbors: Gastrointestinal mucosal structure.

Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells.

Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice.

Acute appendicitis secondary to a granular cell tumor of the appendix in a 19-year-old male.

Elucidating the principles of the molecular organization of heteropolymeric tight junction strands.

Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function.

Bundle-forming pilus retraction enhances enteropathogenic Escherichia coli infectivity.

Cyclic AMP dysregulates intestinal epithelial cell restitution through PKA and RhoA.

TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions.

Dynamic migration of γδ intraepithelial lymphocytes requires occludin.

E-cadherin is critical for collective sheet migration and is regulated by the chemokine CXCL12 protein during restitution.

Myosin light chain kinase: pulling the strings of epithelial tight junction function.

Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury.

Continuing attrition of physician-scientists (CAPS): a preventable syndrome?

Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.

Endothelial and epithelial barriers in graft-versus-host disease.

Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis.

TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis.

Insufficient autoantigen presentation and failure of tolerance in a mouse model of rheumatoid arthritis.

Intestinal permeability defects: is it time to treat?

Inflammation is an independent risk factor for colonic neoplasia in patients with ulcerative colitis: a case-control study.

Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux.

Overactivation of intestinal SREBP2 in mice increases serum cholesterol.

Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-γ.

Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease.

Enteric dysbiosis promotes antibiotic-resistant bacterial infection: systemic dissemination of resistant and commensal bacteria through epithelial transcytosis.

An alteration of the gut-liver axis drives pulmonary inflammation after intoxication and burn injury in mice.

Optical biopsy approaches in Barrett's esophagus with next-generation optical coherence tomography.

Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice.

The role of molecular remodeling in differential regulation of tight junction permeability.

Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1.

Expression of human decay-accelerating factor on intestinal epithelium of transgenic mice does not facilitate infection by the enteral route.

γδ Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice.

Prion protein functions as a ferrireductase partner for ZIP14 and DMT1.

Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease.

Conceptual barriers to understanding physical barriers.

Synergistic Action of Staphylococcus aureus α-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis.

Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability.

Substance P mediates pro-inflammatory cytokine release form mesenteric adipocytes in Inflammatory Bowel Disease patients.

Claudin-2-dependent paracellular channels are dynamically gated.

Beyond Ussing's chambers: contemporary thoughts on integration of transepithelial transport.

Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice.

Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice.

Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model.

ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture.

The intestinal epithelial barrier: a therapeutic target?

Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression.

The mucosal barrier at a glance.

: The Revolution Starts Now.

Histologic Normalization Occurs in Ulcerative Colitis and Is Associated With Improved Clinical Outcomes.

Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function.

Contributions of intestinal epithelial barriers to health and disease.

ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics.

Dynamic modeling of the tight junction pore pathway.

IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance.

The Microbiome Activates CD4 T-cell-mediated Immunity to Compensate for Increased Intestinal Permeability.

Epithelial Organization: The Gut and Beyond.

State of the Journal: CMGH's Progress, Prospects, and Impact Factor.

Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa.

The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations and .

Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability.

Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5 Stem Cells via Inhibition of Wnt and Notch Signaling.

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis.

Rigor, Reproducibility, and Responsibility: A Quantum of Solace.

Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression.

Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease.

Histologic Healing is More Strongly Associated with Clinical Outcomes in Ileal Crohn's Disease than Endoscopic Healing.