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Department of Genetics
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Ozz-E3 ubiquitin ligase targets sarcomeric embryonic myosin heavy chain during muscle development.
PloS one , 2010 | Pubmed ID: 20352047
Alix protein is substrate of Ozz-E3 ligase and modulates actin remodeling in skeletal muscle.
The Journal of biological chemistry Apr, 2012 | Pubmed ID: 22334701
Regulated lysosomal exocytosis mediates cancer progression.
Science advances Dec, 2015 | Pubmed ID: 26824057
Alix-mediated assembly of the actomyosin-tight junction polarity complex preserves epithelial polarity and epithelial barrier.
Nature communications 06, 2016 | Pubmed ID: 27336173
Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis.
Science advances 07, 2019 | Pubmed ID: 31328155
MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat.
Nature communications 08, 2019 | Pubmed ID: 31399583
St. Jude Children's Research Hospital
Diantha van de Vlekkert1,
Xiaohui Qiu1,
Ida Annunziata1,
Alessandra d'Azzo1
1Department of Genetics, St. Jude Children's Research Hospital
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