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San Diego State University Heart Institute and the Department of Biology
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ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart.
Circulation research Mar, 2017 | Pubmed ID: 27932512
CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α.
Journal of molecular and cellular cardiology 02, 2017 | Pubmed ID: 28077321
Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins.
eLife 08, 2018 | Pubmed ID: 30084354
ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb.
Circulation research 01, 2019 | Pubmed ID: 30582446
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.
Nature communications 01, 2019 | Pubmed ID: 30643122
Unfolding the Roles of Mitochondria as Therapeutic Targets for Heart Disease.
Journal of the American College of Cardiology 04, 2019 | Pubmed ID: 30975298
Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart.
Frontiers in cardiovascular medicine , 2019 | Pubmed ID: 32010709
Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α.
International journal of molecular sciences Feb, 2020 | Pubmed ID: 32046286
The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts.
International journal of molecular sciences Feb, 2020 | Pubmed ID: 32085622
Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis.
Cells Mar, 2020 | Pubmed ID: 32138230
Reactive Oxygen Species (ROS)-Activatable Prodrug for Selective Activation of ATF6 after Ischemia/Reperfusion Injury.
ACS medicinal chemistry letters Mar, 2020 | Pubmed ID: 32184959
ATF6 as a Nodal Regulator of Proteostasis in the Heart.
Frontiers in physiology , 2020 | Pubmed ID: 32322217
Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart.
The Journal of biological chemistry May, 2020 | Pubmed ID: 32327487
Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response.
Journal of molecular and cellular cardiology Apr, 2020 | Pubmed ID: 32339566
San Diego State University
Erik A. Blackwood1,
Alina S. Bilal1,
Khalid Azizi1,
Anup Sarakki1,
Christopher C. Glembotski1
1San Diego State University Heart Institute and the Department of Biology, San Diego State University
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