Jennifer Herrmann

Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors.

Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy.

The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles.

Activity-guided screening of bioactive natural compounds implementing a new glucocorticoid-receptor-translocation assay and detection of new anti-inflammatory steroids from bacteria.

In vivo evidence for a prodrug activation mechanism during colibactin maturation.

Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues.

Discovery and biological activity of new chondramides from Chondromyces sp.

Heterologous expression of an orphan NRPS gene cluster from Paenibacillus larvae in Escherichia coli revealed production of sevadicin.

Total syntheses and biological evaluation of miuraenamides.

Biosynthetic Studies of Telomycin Reveal New Lipopeptides with Enhanced Activity.

Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins.

Squalenoylation of Chitosan: A Platform for Drug Delivery?

Rickenyls A-E, antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota).

Effects of Halide Ions on the Carbamidocyclophane Biosynthesis in Nostoc sp. CAVN2.

Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering.

Room temperature electrocompetent bacterial cells improve DNA transformation and recombineering efficiency.

Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies.

Isolation, Structure Elucidation, and (Bio)Synthesis of Haprolid, a Cell-Type-Specific Myxobacterial Cytotoxin.

Strategies for the Discovery and Development of New Antibiotics from Natural Products: Three Case Studies.

Long-Chain Alkyl Cyanides: Unprecedented Volatile Compounds Released by Pseudomonas and Micromonospora Bacteria.

First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-κB Activity As Novel Anticancer Agents.

Novel and revisited approaches in antituberculosis drug discovery.

Structure and Biosynthesis of Crocagins: Polycyclic Posttranslationally Modified Ribosomal Peptides from Chondromyces crocatus.

Pyxipyrrolones: Structure Elucidation and Biosynthesis of Cytotoxic Myxobacterial Metabolites.

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD.

Oxygenated N-Acyl Alanine Methyl Esters (NAMEs) from the Marine Bacterium Roseovarius tolerans EL-164.

A "Motif-Oriented" Total Synthesis of Nannocystin Ax. Preparation and Biological Assessment of Analogues.

Biosynthesis of the Klebsiella oxytoca Pathogenicity Factor Tilivalline: Heterologous Expression, in Vitro Biosynthesis, and Inhibitor Development.

Octapeptins: Lipopeptide Antibiotics against Multidrug-Resistant Superbugs.

Activation of the NLRP3 Inflammasome by Hyaboron, a New Asymmetric Boron-Containing Macrodiolide from the Myxobacterium Hyalangium minutum.

Expressing cytotoxic compounds in Escherichia coli Nissle 1917 for tumor-targeting therapy.

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.

-Acylated amino acid methyl esters from marine group bacteria.

An endothelial cell line infected by Kaposi's sarcoma-associated herpes virus (KSHV) allows the investigation of Kaposi's sarcoma and the validation of novel viral inhibitors in vitro and in vivo.

Aurantimycin resistance genes contribute to survival of Listeria monocytogenes during life in the environment.

Tools for studying the metabolism of new psychoactive substances for toxicological screening purposes - A comparative study using pooled human liver S9, HepaRG cells, and zebrafish larvae.

Engineering Atypical Tetracycline Formation in Amycolatopsis sulphurea for the Production of Modified Chelocardin Antibiotics.

Starch-Chitosan Polyplexes: A Versatile Carrier System for Anti-Infectives and Gene Delivery.

PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus.

Search for hits and early leads from soil bacteria to combat infectious diseases.

Setting Our Sights on Infectious Diseases.

Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics.

Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics.

The glucocorticoid-induced leucine zipper mediates statin-induced muscle damage.

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections.

Toxicokinetics and toxicodynamics of the fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine and furanoyl-1-benzyl-4-anilinopiperidine.

Protein-Templated Hit Identification through an Ugi Four-Component Reaction.

How to Study the Metabolism of New Psychoactive Substances for the Purpose of Toxicological Screenings-A Follow-Up Study Comparing Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae.

Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin.

Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model.