Marc Oria
The Center for Fetal,
Cellular & Molecular Therapy,
Cincinnati Fetal Center,
Division of Pediatric General and Thoracic Surgery,
The Center for Fetal, Cellular & Molecular Therapy, Cincinnati Fetal Center, Division of Pediatric General and Thoracic Surgery
Cincinnati Children’s Hospital Medical Center
I finished my degree in Biology at the University of Barcelona (Spain) in February 2003, and followed this with PhD studies in the group of metabolic encephalopathy, led by Professor Joan Cordoba, which was awarded in March 2011. My research interests during the PhD were focused on the study of the neuronal function in different liver failure animal models.
From September 2003 to January 2004 I had the opportunity to work in close collaboration with the Gastroenterology Group of the Germans Trias y Pujol Hospital (Badalona, Spain), under the supervision of Dr Ramón Bartolí and Dr. Josep Mañè. During this period I gained expertise in the induction of cirrhosis in animal models and worked with IL-10 knockout mice in models of inflammatory intestinal diseases.
In February 2004, I worked in the neuroscience laboratory in Hospital Saint-Luc (Montreal, Canada), led by Dr. Roger Butterworth, where I learned the portacaval anastomosis surgical technique in rats for the development of hepatic encephalopathy in animal models.
In September 2012, I was awarded with Dame Sheila Sherlock EASL Post-Doctoral Fellowship to develop a new project at the University College of London (UCL) wit Prof. Rajiv Jalan. During this post-doc experience I developed new skills in molecular biology working in the activated senescence pathways in the brain from liver disease animal models.
In 2013 I started a new research line as a Post-doc and now as a Faculty at the Center for Fetal and Placental Research at the Cincinnati Children's Hospital Medical Center (CCHMC) studying the effect of spina bifida and hydrocephalus on the central nervous and possible therapies.
During my training process from 2003 till now, I established relationship with several scientists around the world and I published in top journals with high impact factor.
Complete rat spinal cord transection as a faithful model of spinal cord injury for translational cell transplantation.
Scientific reports Apr, 2015 | Pubmed ID: 25860664
What we know: the inflammatory basis of hepatic encephalopathy.
Metabolic brain disease 12, 2016 | Pubmed ID: 26497651
Role of intraluminal bowel echogenicity on prenatal ultrasounds to determine the anatomical level of intestinal atresia.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Jan, 2017 | Pubmed ID: 27023781
Cerebellar neurodegeneration in a new rat model of episodic hepatic encephalopathy.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Mar, 2017 | Pubmed ID: 27154504
Gene expression profiling of brain cortex microvessels may support brain vasodilation in acute liver failure rat models.
Metabolic brain disease 12, 2016 | Pubmed ID: 27406245
Excessive Reversal of Epidermal Growth Factor Receptor and Ephrin Signaling Following Tracheal Occlusion in Rabbit Model of Congenital Diaphragmatic Hernia.
Molecular medicine (Cambridge, Mass.) Sep, 2016 | Pubmed ID: 27452320
Isolation, characterization, and differentiation of multipotent neural progenitor cells from human cerebrospinal fluid in fetal cystic myelomeningocele.
Stem cell research 07, 2017 | Pubmed ID: 28578005
Using poly(l-lactic acid) and poly(ɛ-caprolactone) blends to fabricate self-expanding, watertight and biodegradable surgical patches for potential fetoscopic myelomeningocele repair.
Journal of biomedical materials research. Part B, Applied biomaterials 02, 2019 | Pubmed ID: 29770571
Fetal tracheal occlusion in mice: a novel transuterine method.
The Journal of surgical research 09, 2018 | Pubmed ID: 29937007
CD200-CD200R imbalance correlates with microglia and pro-inflammatory activation in rat spinal cords exposed to amniotic fluid in retinoic acid-induced spina bifida.
Scientific reports Jul, 2018 | Pubmed ID: 30006626
Proteomic profiling of tracheal fluid in an ovine model of congenital diaphragmatic hernia and fetal tracheal occlusion.
American journal of physiology. Lung cellular and molecular physiology 12, 2018 | Pubmed ID: 30260286
Optimization of Pulmonary Vasculature Tridimensional Phenotyping in The Rat Fetus.
Scientific reports 02, 2019 | Pubmed ID: 30718645
Comparative study of intracisternal kaolin injection techniques to induce congenital hydrocephalus in fetal lamb.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 05, 2019 | Pubmed ID: 30805823
In Vivo Evaluation of Novel PLA/PCL Polymeric Patch in Rats for Potential Spina Bifida Coverage.
The Journal of surgical research 10, 2019 | Pubmed ID: 31071606
Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis.
Cell death & disease 09, 2019 | Pubmed ID: 31558708
Intracisternal BioGlue injection in the fetal lamb: a novel model for creation of obstructive congenital hydrocephalus without additional chemically induced neuroinflammation.
Journal of neurosurgery. Pediatrics Sep, 2019 | Pubmed ID: 31561226
Fetal brain damage in congenital hydrocephalus.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 08, 2020 | Pubmed ID: 32451664
Innovative, Stabilizing Self-Expandable Patch for Easier and Safer Thoracoscopic Repair of Congenital Diaphragmatic Hernia.
Journal of laparoendoscopic & advanced surgical techniques. Part A Nov, 2020 | Pubmed ID: 32960151
Transuterine Fetal Tracheal Occlusion Model in Mice
Emrah Aydın1,2,
Rashika Joshi3,
Marc Oria1,
Foong-Yen Lim1,
Brian Michael Varisco3,
Jose Luis Peiro1
1The Center for Fetal, Cellular & Molecular Therapy, Cincinnati Fetal Center, Division of Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center,
2Department of Pediatric Surgery, Tekirdag Namik Kemal University School of Medicine,
3The Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center
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