Leonard Zon

Organogenesis--heart and blood formation from the zebrafish point of view.

Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafish.

Hematopoiesis and stem cells: plasticity versus developmental heterogeneity.

Walking the walk: migration and other common themes in blood and vascular development.

Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies.

Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning.

Zebrafish as a cancer model system.

Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish.

Attack of the fish clones.

Characterization of zebrafish merlot/chablis as non-mammalian vertebrate models for severe congenital anemia due to protein 4.1 deficiency.

Isolation and characterization of zebrafish NFE2.

The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1).

SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization.

SUMO-1 protease-1 regulates gene transcription through PML.

Portrait of a stem cell.

Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators.

Ontogeny of hematopoiesis: examining the emergence of hematopoietic cells in the vertebrate embryo.

Biomedicine. Love, honor, and protect (your liver).

Myc-induced T cell leukemia in transgenic zebrafish.

Characterization of embryonic globin genes of the zebrafish.

Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency.

Cancer genetics and drug discovery in the zebrafish.

The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish.

Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects.

The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans.

cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes.

Modeling human hematopoietic and cardiovascular diseases in zebrafish.

Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants.

Allan j. Erslev, m.d.: truly a great dane (1919-2003).

The zebrafish as a model organism to study development of the immune system.

The pu.1 promoter drives myeloid gene expression in zebrafish.

The use of zebrafish to understand immunity.

In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.

Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation.

Expression and mapping of duplicate neuropilin-1 and neuropilin-2 genes in developing zebrafish.

Taking the stem cell debate to the public.

Two distinct teleost hepatocyte nuclear factor 1 genes, hnf1alpha/tcf1 and hnf1beta/tcf2, abundantly expressed in liver, pancreas, gut and kidney of zebrafish.

The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis.

The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis.

Analysis of hematopoietic development in the zebrafish.

Hematopoietic gene expression profile in zebrafish kidney marrow.

The clinical potential of stem cells.

An Mll-dependent Hox program drives hematopoietic progenitor expansion.

The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1.

Use of the DsRed fluorescent reporter in zebrafish.

The Zon laboratory guide to positional cloning in zebrafish.

Zebrafish scl functions independently in hematopoietic and endothelial development.

Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos.

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.

In vivo drug discovery in the zebrafish.

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.

The zebrafish: a new model of T-cell and thymic development.

Mutant-specific gene programs in the zebrafish.

The complex cartography of stem cell commitment.

Regulation of the lmo2 promoter during hematopoietic and vascular development in zebrafish.

Ferroportin1 is required for normal iron cycling in zebrafish.

Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization.

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.

Analysis of thrombocyte development in CD41-GFP transgenic zebrafish.

Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.

Transcriptional regulation of hematopoietic stem cell development in zebrafish.

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.

Hematopoietic stem cell fate is established by the Notch-Runx pathway.

Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching.

Zebrafish to humans: evolution of the alpha3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndrome.

Use of the zebrafish system to study primitive and definitive hematopoiesis.

A critical role for calponin 2 in vascular development.

Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism.

Piloting the zebrafish genome browser.

Small molecules that delay S phase suppress a zebrafish bmyb mutant.

The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis.

Mitoferrin is essential for erythroid iron assimilation.

BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis.

AlphaA-crystallin expression prevents gamma-crystallin insolubility and cataract formation in the zebrafish cloche mutant lens.

A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro.

Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.

A chemical genetic screen for cell cycle inhibitors in zebrafish embryos.

Homing sweet homing: odyssey of hematopoietic stem cells.

A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.

Gene Duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a.

Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord.

Zebrafish orthologs of human muscular dystrophy genes.

Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110.

Effects of RAS on the genesis of embryonal rhabdomyosarcoma.

Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish.

New waves of discovery: modeling cancer in zebrafish.

Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors.

The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization.

Functional conservation of erythropoietin signaling in zebrafish.

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.

Definition of the zebrafish genome using flow cytometry and cytogenetic mapping.

The zebrafish runzel muscular dystrophy is linked to the titin gene.

Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish.

Generation and characterization of transgenic zebrafish lines using different ubiquitous promoters.

APC and colon cancer: two hits for one.

Prostaglandin E2: making more of your marrow.

Combinatorial regulation of novel erythroid gene expression in zebrafish.

Taking human cancer genes to the fish: a transgenic model of melanoma in zebrafish.

Hematopoiesis: an evolving paradigm for stem cell biology.

SnapShot: hematopoiesis.

Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE).

Cell stem cell.

Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera.

BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway.

Transparent adult zebrafish as a tool for in vivo transplantation analysis.

Use of zebrafish models for the analysis of human disease.

Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal.

Zebrafish VEGF receptors: a guideline to nomenclature.

Self-renewal and differentiation at Cell Stem Cell.

montalcino, A zebrafish model for variegate porphyria.

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.

Zebrafish mutants with disrupted early T-cell and thymus development identified in early pressure screen.

Melanocytes in development, regeneration, and cancer.

Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish.

Intestinal differentiation in zebrafish requires Cdx1b, a functional equivalent of mammalian Cdx2.

A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis.

Construction and application of a zebrafish array comparative genomic hybridization platform.

Transferrin-a modulates hepcidin expression in zebrafish embryos.

Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish.

Melanoma biology and the promise of zebrafish.

The effect of a depth gradient on the mating behavior, oviposition site preference, and embryo production in the zebrafish, Danio rerio.

Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.

A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence.

Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish.

Zebrafish kidney stromal cell lines support multilineage hematopoiesis.

Hematopoietic stem cell development is dependent on blood flow.

Zebrafish blood stem cells.

Defining cancer stem cells by xenotransplantation in zebrafish.

Chemical genetic screening in the zebrafish embryo.

Melanocytes in development and cancer.

Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish.

Zebrafish tumor assays: the state of transplantation.

High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia.

Derivation of adult stem cells during embryogenesis.

Swimming into the future of drug discovery: in vivo chemical screens in zebrafish.

Resolving the controversy about N-cadherin and hematopoietic stem cells.

Small molecule screen in zebrafish and HSC expansion.

The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.

Interaction of retinoic acid and scl controls primitive blood development.

The new age of chemical screening in zebrafish.

A chemical genetic screen in zebrafish for pathways interacting with cdx4 in primitive hematopoiesis.

Newly emerging roles for prostaglandin E2 regulation of hematopoiesis and hematopoietic stem cell engraftment.

Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis.

TIF1gamma controls erythroid cell fate by regulating transcription elongation.

Blood flow: metalloproteases cut loose in primitive erythrocytes.

Fishing at the cellular level.

Zebrafish models of p53 functions.

Hematopoietic development in the zebrafish.

PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury.

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

The zebrafish: cellular and developmental biology, part A. Preface.

Stem cells: The blood balance.

Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish.

Lessons from the Niche for Generation and Expansion of Hematopoietic Stem Cells.

The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies.

The ERGonomics of hematopoietic stem cell self-renewal.

cpsf1 is required for definitive HSC survival in zebrafish.

Isolation and transcriptome analysis of adult zebrafish cells enriched for skeletal muscle progenitors.

Characterization of immune-matched hematopoietic transplantation in zebrafish.

Clonal analysis of hematopoietic progenitor cells in the zebrafish.

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset.

DHODH modulates transcriptional elongation in the neural crest and melanoma.

Modeling Diamond Blackfan anemia in the zebrafish.

Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models.

Stem cell migration: a zebrafish model.

Stromal cell-derived factor-1 and hematopoietic cell homing in an adult zebrafish model of hematopoietic cell transplantation.

Zebrafish as a model for normal and malignant hematopoiesis.

A new system for the rapid collection of large numbers of developmentally staged zebrafish embryos.

Genetic suppressor screens in haploids.

Advanced zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments.

The zon laboratory guide to positional cloning in zebrafish.

Chromatin immunoprecipitation in adult zebrafish red cells.

The NOTCH pathway contributes to cell fate decision in myelopoiesis.

Transplantation in zebrafish.

Chemical screening in zebrafish for novel biological and therapeutic discovery.

Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration.

The zebrafish. Preface.

Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation.

An optical platform for cell tracking in adult zebrafish.

Extensive genetic diversity and substructuring among zebrafish strains revealed through copy number variant analysis.

Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model.

Linking hematopoietic regeneration to developmental signaling pathways: A story of BMP and Wnt.

Stem cells: The right neighbour.

Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.

Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway.

Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR.

A great match.

Hooked! Modeling human disease in zebrafish.

Histocompatibility and hematopoietic transplantation in the zebrafish.

Cancer and inflammation: an aspirin a day keeps the cancer at bay.

Formation of a PKCζ/β-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting.

Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53.

A splice site mutation in laminin-α2 results in a severe muscular dystrophy and growth abnormalities in zebrafish.

Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis.

Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.

In situ hybridization assay-based small molecule screening in zebrafish.

CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development.

The transcriptional landscape of hematopoietic stem cell ontogeny.

TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.

Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish.

Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition.

Ageing: Stem cells on a stress-busting diet.

Potential of zebrafish for anticancer drug screening.

A model for primary melanoma of the CNS implicates NRAS.

The zebrafish reference genome sequence and its relationship to the human genome.

A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.

The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish.

Hematopoiesis.

Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system.

Small molecule screening in zebrafish: swimming in potential drug therapies.

Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis.

Assaying hematopoiesis using zebrafish.

Zebrafish cancer: the state of the art and the path forward.

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.

The zebrafish granulocyte colony stimulating factors (Gcsfs): two paralogous cytokines and their roles in hematopoietic development and maintenance.

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.

zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish.

A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species.

A network of epigenetic regulators guides developmental haematopoiesis in vivo.

Of fish and men: using zebrafish to fight human diseases.

A Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis.

Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish.

A non-canonical function of telomerase RNA in the regulation of developmental myelopoiesis in zebrafish.

Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development.

Translational research: the path for bringing discovery to patients.

Unexpectedly uneven: posttransplant skeletal distribution of hematopoietic stem cell clones.

Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures.

Neural crest development and craniofacial morphogenesis is coordinated by nitric oxide and histone acetylation.

Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families.

Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin.

From fish tank to bedside in cancer therapy: an interview with Leonard Zon.

Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size.

Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2.

Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4).

A comparison of non-integrating reprogramming methods.

A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.

Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.

Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche.

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling.

A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish.

Screening for melanoma resistance genes in vivo.