BHF Centre of Research Excellence,
Division of Cardiovascular Medicine,
Radcliffe Department of Medicine,
John Radcliffe Hospital,
Wellcome Centre for Human Genetics,
BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital
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Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction.
Arteriosclerosis, thrombosis, and vascular biology Mar, 2008 | Pubmed ID: 18096829
CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
Circulation Sep, 2008 | Pubmed ID: 18824773
Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin.
Atherosclerosis Mar, 2010 | Pubmed ID: 19781706
RVX-208, a stimulator of apolipoprotein AI gene expression for the treatment of cardiovascular diseases.
Current opinion in investigational drugs (London, England : 2000) Mar, 2010 | Pubmed ID: 20178050
Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications.
Clinical science (London, England : 1979) Mar, 2010 | Pubmed ID: 20210786
Site-directed mutagenesis of the CC chemokine binding protein 35K-Fc reveals residues essential for activity and mutations that increase the potency of CC chemokine blockade.
Molecular pharmacology Aug, 2011 | Pubmed ID: 21586597
Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification.
European heart journal Sep, 2012 | Pubmed ID: 23008511
The role of tetrahydrobiopterin in inflammation and cardiovascular disease.
Thrombosis and haemostasis Nov, 2012 | Pubmed ID: 23052970
A real time chemotaxis assay unveils unique migratory profiles amongst different primary murine macrophages.
PloS one , 2013 | Pubmed ID: 23516549
The downstream regulation of chemokine receptor signalling: implications for atherosclerosis.
Mediators of inflammation , 2013 | Pubmed ID: 23690662
Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.
Circulation Sep, 2013 | Pubmed ID: 24030421
Tetrahydrobiopterin in cardiovascular health and disease.
Antioxidants & redox signaling Jun, 2014 | Pubmed ID: 24294830
Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Hypertension (Dallas, Tex. : 1979) Sep, 2014 | Pubmed ID: 24777984
Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection.
Circulation Jun, 2014 | Pubmed ID: 24807872
Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo.
Blood Oct, 2014 | Pubmed ID: 25030063
Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis.
Journal of molecular medicine (Berlin, Germany) Nov, 2014 | Pubmed ID: 25077938
Fractalkine promotes human monocyte survival via a reduction in oxidative stress.
Arteriosclerosis, thrombosis, and vascular biology Dec, 2014 | Pubmed ID: 25359863
Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
Free radical biology & medicine Feb, 2015 | Pubmed ID: 25451639
Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2015 | Pubmed ID: 25675482
RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling.
Nature communications Mar, 2015 | Pubmed ID: 25782711
Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension.
Vascular pharmacology Feb, 2016 | Pubmed ID: 26276526
Hydrodynamic Gene Delivery of CC Chemokine Binding Fc Fusion Proteins to Target Acute Vascular Inflammation In Vivo.
Scientific reports Dec, 2015 | Pubmed ID: 26620767
Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo.
eLife 08, 2016 | Pubmed ID: 27572261
Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP/ApoE-/- Reporter Mouse-Brief Report.
Arteriosclerosis, thrombosis, and vascular biology Feb, 2017 | Pubmed ID: 27908893
A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.
British journal of pharmacology 04, 2017 | Pubmed ID: 28128438
Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes.
Antioxidants & redox signaling 07, 2018 | Pubmed ID: 28661198
Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction.
JCI insight 09, 2017 | Pubmed ID: 28878126
Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T.
PloS one , 2018 | Pubmed ID: 29324754
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
Cardiovascular research 08, 2018 | Pubmed ID: 29596571
Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.
Hypertension (Dallas, Tex. : 1979) 07, 2018 | Pubmed ID: 29844152
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Nature 11, 2018 | Pubmed ID: 30405245
Improved cellular uptake of perfluorocarbon nanoparticles for in vivo murine cardiac F MRS/MRI and temporal tracking of progenitor cells.
Nanomedicine : nanotechnology, biology, and medicine 06, 2019 | Pubmed ID: 30448526
Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin.
Nature communications 12, 2018 | Pubmed ID: 30573728
Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity.
Proceedings of the National Academy of Sciences of the United States of America 04, 2019 | Pubmed ID: 30944221
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
Cell reports 07, 2019 | Pubmed ID: 31269442
Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Nature Aug, 2019 | Pubmed ID: 31363232
Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.
Science translational medicine 09, 2019 | Pubmed ID: 31534019
Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology.
Nitric oxide : biology and chemistry 08, 2020 | Pubmed ID: 32339668
When the genome bluffs: a tandem duplication event during generation of a novel Agmo knockout mouse model fools routine genotyping.
Cell & bioscience Mar, 2021 | Pubmed ID: 33726865
Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth.
Hypertension (Dallas, Tex. : 1979) 12, 2021 | Pubmed ID: 34689592
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