Robert L. Hettich

Formation and characterization of iron-oligonucleotide complexes with matrix-assisted laser desorption/ionization fourier transform ion cyclotron resonance mass spectrometry.

Intact protein analysis for site-directed mutagenesis overexpression products: plasmid-encoded R67 dihydrofolate reductase.

Protein surface mapping by chemical oxidation: structural analysis by mass spectrometry.

Integrating 'top-down" and "bottom-up" mass spectrometric approaches for proteomic analysis of Shewanella oneidensis.

Analysis of protein solvent accessible surfaces by photochemical oxidation and mass spectrometry.

A computational method for assessing peptide- identification reliability in tandem mass spectrometry analysis with SEQUEST.

Characterization of the 70S Ribosome from Rhodopseudomonas palustris using an integrated "top-down" and "bottom-up" mass spectrometric approach.

Transcriptomic and proteomic characterization of the Fur modulon in the metal-reducing bacterium Shewanella oneidensis.

DBDigger: reorganized proteomic database identification that improves flexibility and speed.

Photochemical surface mapping of C14S-Sml1p for constrained computational modeling of protein structure.

Multipole-storage-assisted dissociation for the characterization of large proteins and simple protein mixtures by ESI-FTICR-MS.

53rd American Society for Mass Spectrometry Conference. 5-9 June, 2005, Henry B Gonzalez Conference Center, San Antonio, TX, USA.

MASPIC: intensity-based tandem mass spectrometry scoring scheme that improves peptide identification at high confidence.

Determination and comparison of the baseline proteomes of the versatile microbe Rhodopseudomonas palustris under its major metabolic states.

Molecular dynamics of the Shewanella oneidensis response to chromate stress.

Determination of peptide and protein ion charge states by Fourier transformation of isotope-resolved mass spectra.

Characterization of pII family (GlnK1, GlnK2, and GlnB) protein uridylylation in response to nitrogen availability for Rhodopseudomonas palustris.

Global molecular and morphological effects of 24-hour chromium(VI) exposure on Shewanella oneidensis MR-1.

Robust estimation of peptide abundance ratios and rigorous scoring of their variability and bias in quantitative shotgun proteomics.

ProRata: A quantitative proteomics program for accurate protein abundance ratio estimation with confidence interval evaluation.

Detecting differential and correlated protein expression in label-free shotgun proteomics.

Dosage-dependent proteome response of Shewanella oneidensis MR-1 to acute chromate challenge.

Characterization of anaerobic catabolism of p-coumarate in Rhodopseudomonas palustris by integrating transcriptomics and quantitative proteomics.

Systematic assessment of the benefits and caveats in mining microbial post-translational modifications from shotgun proteomic data: the response of Shewanella oneidensis to chromate exposure.

Development of an electrochemical oxidation method for probing higher order protein structure with mass spectrometry.

Characterization of cytochrome 579, an unusual cytochrome isolated from an iron-oxidizing microbial community.

Shotgun metaproteomics of the human distal gut microbiota.

Experimental approach for deep proteome measurements from small-scale microbial biomass samples.

Comparative temporal proteomics of a response regulator (SO2426)-deficient strain and wild-type Shewanella oneidensis MR-1 during chromate transformation.

Systems biology: Functional analysis of natural microbial consortia using community proteomics.

Phenotype fingerprinting suggests the involvement of single-genotype consortia in degradation of aromatic compounds by Rhodopseudomonas palustris.

Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla.

Differential accumulation of form I RubisCO in Rhodopseudomonas palustris CGA010 under Photoheterotrophic growth conditions with reduced carbon sources.

Community genomic and proteomic analyses of chemoautotrophic iron-oxidizing "Leptospirillum rubarum" (Group II) and "Leptospirillum ferrodiazotrophum" (Group III) bacteria in acid mine drainage biofilms.

Proteogenomic monitoring of Geobacter physiology during stimulated uranium bioremediation.

PTMSearchPlus: software tool for automated protein identification and post-translational modification characterization by integrating accurate intact protein mass and bottom-up mass spectrometric data searches.

A high-throughput de novo sequencing approach for shotgun proteomics using high-resolution tandem mass spectrometry.

Enigmatic, ultrasmall, uncultivated Archaea.

Proteomics reveals a core molecular response of Pseudomonas putida F1 to acute chromate challenge.

Ecological distribution and population physiology defined by proteomics in a natural microbial community.

Direct cellular lysis/protein extraction protocol for soil metaproteomics.

Metabolome-proteome differentiation coupled to microbial divergence.

Quantitative proteomic analyses of the response of acidophilic microbial communities to different pH conditions.

Quantitative tracking of isotope flows in proteomes of microbial communities.

Discovery and annotation of small proteins using genomics, proteomics, and computational approaches.

Use of label-free quantitative proteomics to distinguish the secreted cellulolytic systems of Caldicellulosiruptor bescii and Caldicellulosiruptor obsidiansis.

Identification of biofilm matrix-associated proteins from an acid mine drainage microbial community.

Proteomic characterization of cellular and molecular processes that enable the Nanoarchaeum equitans--Ignicoccus hospitalis relationship.

Label-free quantitative proteomics for the extremely thermophilic bacterium Caldicellulosiruptor obsidiansis reveal distinct abundance patterns upon growth on cellobiose, crystalline cellulose, and switchgrass.

Defining the boundaries and characterizing the landscape of functional genome expression in vascular tissues of Populus using shotgun proteomics.

Comparative shotgun proteomic analysis of Clostridium acetobutylicum from butanol fermentation using glucose and xylose.

Microbes in thawing permafrost: the unknown variable in the climate change equation.

Strategies for metagenomic-guided whole-community proteomics of complex microbial environments.

Systematic comparison of label-free, metabolic labeling, and isobaric chemical labeling for quantitative proteomics on LTQ Orbitrap Velos.

Microbial metaproteomics: identifying the repertoire of proteins that microorganisms use to compete and cooperate in complex environmental communities.

Caldicellulosiruptor core and pangenomes reveal determinants for noncellulosomal thermophilic deconstruction of plant biomass.

Phage-induced expression of CRISPR-associated proteins is revealed by shotgun proteomics in Streptococcus thermophilus.

Clostridium thermocellum ATCC27405 transcriptomic, metabolomic and proteomic profiles after ethanol stress.

Putting the pieces together: high-performance LC-MS/MS provides network-, pathway-, and protein-level perspectives in Populus.

Biostimulation induces syntrophic interactions that impact C, S and N cycling in a sediment microbial community.

Role of the CipA scaffoldin protein in cellulose solubilization, as determined by targeted gene deletion and complementation in Clostridium thermocellum.

Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease.

Experimental approach to controllably vary protein oxidation while minimizing electrode adsorption for boron-doped diamond electrochemical surface mapping applications.

Characterizing the range of extracellular protein post-translational modifications in a cellulose-degrading bacteria using a multiple proteolyic digestion/peptide fragmentation approach.

Metaproteomics: harnessing the power of high performance mass spectrometry to identify the suite of proteins that control metabolic activities in microbial communities.

New group in the Leptospirillum clade: cultivation-independent community genomics, proteomics, and transcriptomics of the new species "Leptospirillum group IV UBA BS".

Insights into the structure and metabolic function of microbes that shape pelagic iron-rich aggregates ("iron snow").

Comparative informatics analysis to evaluate site-specific protein oxidation in multidimensional LC-MS/MS data.

Isolation and chemical analysis of nanoparticles from English ivy (Hedera helix L.).

Environmental proteomics reveals early microbial community responses to biostimulation at a uranium- and nitrate-contaminated site.

Effects of diet on resource utilization by a model human gut microbiota containing Bacteroides cellulosilyticus WH2, a symbiont with an extensive glycobiome.

Identification and environmental distribution of dcpA, which encodes the reductive dehalogenase catalyzing the dichloroelimination of 1,2-dichloropropane to propene in organohalide-respiring chloroflexi.

Development of a multipoint quantitation method to simultaneously measure enzymatic and structural components of the Clostridium thermocellum cellulosome protein complex.

Recoding of the stop codon UGA to glycine by a BD1-5/SN-2 bacterium and niche partitioning between Alpha- and Gammaproteobacteria in a tidal sediment microbial community naturally selected in a laboratory chemostat.

Metaproteomics: extracting and mining proteome information to characterize metabolic activities in microbial communities.

Life on the edge: functional genomic response of Ignicoccus hospitalis to the presence of Nanoarchaeum equitans.

Elevated temperature alters proteomic responses of individual organisms within a biofilm community.

Diverse and divergent protein post-translational modifications in two growth stages of a natural microbial community.

Nitrogen cycling. The environmental controls that govern the end product of bacterial nitrate respiration.

Development of an enhanced metaproteomic approach for deepening the microbiome characterization of the human infant gut.

A comparative multidimensional LC-MS proteomic analysis reveals mechanisms for furan aldehyde detoxification in Thermoanaerobacter pseudethanolicus 39E.

Discrete and structurally unique proteins (tāpirins) mediate attachment of extremely thermophilic Caldicellulosiruptor species to cellulose.

Microbial metaproteomics for characterizing the range of metabolic functions and activities of human gut microbiota.

Metagenome sequencing of a coastal marine microbial community from monterey bay, california.

Critical biogeochemical functions in the subsurface are associated with bacteria from new phyla and little studied lineages.

Metaproteomics reveals functional shifts in microbial and human proteins during a preterm infant gut colonization case.

Rescuing Those Left Behind: Recovering and Characterizing Underdigested Membrane and Hydrophobic Proteins To Enhance Proteome Measurement Depth.

A roadmap for research on crassulacean acid metabolism (CAM) to enhance sustainable food and bioenergy production in a hotter, drier world.

Strain-resolved microbial community proteomics reveals simultaneous aerobic and anaerobic function during gastrointestinal tract colonization of a preterm infant.

Untargeted metabolomics studies employing NMR and LC-MS reveal metabolic coupling between and its archaeal host .

Integrating mRNA and Protein Sequencing Enables the Detection and Quantitative Profiling of Natural Protein Sequence Variants of Populus trichocarpa.

Draft Genome Sequence of Streptomyces vitaminophilus ATCC 31673, a Producer of Pyrrolomycin Antibiotics, Some of Which Contain a Nitro Group.

Characterization of Fatty Acids in Crenarchaeota by GC-MS and NMR.

Fungi Contribute Critical but Spatially Varying Roles in Nitrogen and Carbon Cycling in Acid Mine Drainage.

Dramatic performance of Clostridium thermocellum explained by its wide range of cellulase modalities.

Proteomic Stable Isotope Probing Reveals Biosynthesis Dynamics of Slow Growing Methane Based Microbial Communities.

Simultaneous achievement of high ethanol yield and titer in Clostridium thermocellum.

Genomics-informed isolation and characterization of a symbiotic Nanoarchaeota system from a terrestrial geothermal environment.

Metabolic Regulation as a Consequence of Anaerobic 5-Methylthioadenosine Recycling in Rhodospirillum rubrum.

Global Proteome Response to Deletion of Genes Related to Mercury Methylation and Dissimilatory Metal Reduction Reveals Changes in Respiratory Metabolism in Geobacter sulfurreducens PCA.

Reconstructing a hydrogen-driven microbial metabolic network in Opalinus Clay rock.

Proteomic Stable Isotope Probing Reveals Taxonomically Distinct Patterns in Amino Acid Assimilation by Coastal Marine Bacterioplankton.

Proteogenomic analyses indicate bacterial methylotrophy and archaeal heterotrophy are prevalent below the grass root zone.

Transcript, protein and metabolite temporal dynamics in the CAM plant Agave.

Transcriptomic and proteomic insights into innate immunity and adaptations to a symbiotic lifestyle in the gutless marine worm Olavius algarvensis.

Improved growth rate in hydrogenase mutant via perturbed sulfur metabolism.

Impacts of chemical gradients on microbial community structure.

The protein and neutral lipid composition of lipid droplets isolated from the fission yeast, Schizosaccharomyces pombe.

Genome-Resolved Meta-Omics Ties Microbial Dynamics to Process Performance in Biotechnology for Thiocyanate Degradation.

Pentose sugars inhibit metabolism and increase expression of an AgrD-type cyclic pentapeptide in Clostridium thermocellum.

Specialized activities and expression differences for Clostridium thermocellum biofilm and planktonic cells.

The effects of micronutrient deficiencies on bacterial species from the human gut microbiota.

Optimized Extraction Method To Remove Humic Acid Interferences from Soil Samples Prior to Microbial Proteome Measurements.

Multi-omics analysis provides insight to the Ignicoccus hospitalis-Nanoarchaeum equitans association.

Genome-resolved metaproteomic characterization of preterm infant gut microbiota development reveals species-specific metabolic shifts and variabilities during early life.

Methane-Fueled Syntrophy through Extracellular Electron Transfer: Uncovering the Genomic Traits Conserved within Diverse Bacterial Partners of Anaerobic Methanotrophic Archaea.

Phylogenetically conserved resource partitioning in the coastal microbial loop.

Grape pomace compost harbors organohalide-respiring Dehalogenimonas species with novel reductive dehalogenase genes.

Mechanisms of subzero growth in the cryophile Planococcus halocryophilus determined through proteomic analysis.

Erratum for Skennerton et al., "Methane-Fueled Syntrophy through Extracellular Electron Transfer: Uncovering the Genomic Traits Conserved within Diverse Bacterial Partners of Anaerobic Methanotrophic Archaea".

Functional Analysis of the Glucan Degradation Locus in Caldicellulosiruptor bescii Reveals Essential Roles of Component Glycoside Hydrolases in Plant Biomass Deconstruction.

Identification of peptide-binding sites within BSA using rapid, laser-induced covalent cross-linking combined with high-performance mass spectrometry.

Maternal consumption of fish oil programs reduced adiposity in broiler chicks.

Development of a plasmid-based expression system in and its use to screen heterologous expression of bifunctional alcohol dehydrogenases (s).

Eliminating a global regulator of carbon catabolite repression enhances the conversion of aromatic lignin monomers to muconate in KT2440.

The Kalanchoë genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism.

Deletion of the gene increases ethanol production in and several other thermophilic anaerobic bacteria.

Phosphorylation of Ribosomal Protein RPS6 Integrates Light Signals and Circadian Clock Signals.

Quantitative proteome profile of water deficit stress responses in eastern cottonwood (Populus deltoides) leaves.

The diversity and specificity of the extracellular proteome in the cellulolytic bacterium is driven by the nature of the cellulosic growth substrate.

Hospitalized Premature Infants Are Colonized by Related Bacterial Strains with Distinct Proteomic Profiles.

Quantitative Proteomic Analysis of Biological Processes and Responses of the Bacterium Desulfovibrio desulfuricans ND132 upon Deletion of Its Mercury Methylation Genes.

Author Correction: Maternal consumption of fish oil programs reduced adiposity in broiler chicks.

Diel rewiring and positive selection of ancient plant proteins enabled evolution of CAM photosynthesis in Agave.

Transcriptomic and proteomic changes from medium supplementation and strain evolution in high-yielding Clostridium thermocellum strains.

Biogeochemical Cycling by a Low-Diversity Microbial Community in Deep Groundwater.

Utilization of a Detergent-Based Method for Direct Microbial Cellular Lysis/Proteome Extraction from Soil Samples for Metaproteomics Studies.

Quantifying codon usage in signal peptides: Gene expression and amino acid usage explain apparent selection for inefficient codons.

Comparative Genomics and Proteomic Analysis of Assimilatory Sulfate Reduction Pathways in Anaerobic Methanotrophic Archaea.

Proteogenomics Reveals Novel Reductive Dehalogenases and Methyltransferases Expressed during Anaerobic Dichloromethane Metabolism.

Progress and Challenges in Ocean Metaproteomics and Proposed Best Practices for Data Sharing.

Metaproteomics reveals persistent and phylum-redundant metabolic functional stability in adult human gut microbiomes of Crohn's remission patients despite temporal variations in microbial taxa, genomes, and proteomes.

Evaluation of an untargeted nano-liquid chromatography-mass spectrometry approach to expand coverage of low molecular weight dissolved organic matter in Arctic soil.

Scavenging organic nitrogen and remodelling lipid metabolism are key survival strategies adopted by the endophytic fungi, Serendipita vermifera and Serendipita bescii to alleviate nitrogen and phosphorous starvation in vitro.

Correction to: Diel rewiring and positive selection of ancient plant proteins enabled evolution of CAM photosynthesis in Agave.

Exploiting the Dynamic Relationship between Peptide Separation Quality and Peptide Coisolation in a Multiple-Peptide Matches-per-Spectrum Approach Offers a Strategy To Optimize Bottom-Up Proteomics Throughput and Depth.

One-time nitrogen fertilization shifts switchgrass soil microbiomes within a context of larger spatial and temporal variation.

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.

Targeted detection of Dehalococcoides mccartyi microbial protein biomarkers as indicators of reductive dechlorination activity in contaminated groundwater.

Surface Water Microbial Community Response to the Biocide 2,2-Dibromo-3-Nitrilopropionamide, Used in Unconventional Oil and Gas Extraction.

Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans.

Bioremediation of a Common Product of Food Processing by a Human Gut Bacterium.

Impact of Fixed Nitrogen Availability on Reductive Dechlorination Activity.

Comparing DNA, RNA and protein levels for measuring microbial dynamics in soil microcosms amended with nitrogen fertilizer.

Integrated Proteomics and Lipidomics Reveal That the Swarming Motility of Is Characterized by Phospholipid Modification, Surfactant Deployment, and Flagellar Specialization Relative to Swimming Motility.

Genome-Resolved Proteomic Stable Isotope Probing of Soil Microbial Communities Using CO and C-Methanol.

Active sulfur cycling in the terrestrial deep subsurface.

Gene targets for engineering osmotolerance in .

Outer membrane vesicles catabolize lignin-derived aromatic compounds in KT2440.

Impact of Fatty-Acid Labeling of Membranes on the Cellular Lipidome and Proteome.

A Viable New Strategy for the Discovery of Peptide Proteolytic Cleavage Products in Plant-Microbe Interactions.

Biogeography of microbial bile acid transformations along the murine gut.

Characterizing Intracellular Proteomes for Microbes: An Experimental Approach Using Label-Free Protein Quantitation.

Molecular Remodeling in Populus PdKOR RNAi Roots Profiled Using LC-MS/MS Proteomics.

A nitrogenase-like enzyme system catalyzes methionine, ethylene, and methane biogenesis.

A carotenoid-deficient mutant of the plant-associated microbe Pantoea sp. YR343 displays an altered membrane proteome.

Structural and Proteomic Studies of the Virus Demonstrate a Global Distribution of Virus-Encoded Carbohydrate Processing.

Targeted Growth Medium Dropouts Promote Aromatic Compound Synthesis in Crude Cell-Free Systems.

Coculture with hemicellulose-fermenting microbes reverses inhibition of corn fiber solubilization by Clostridium thermocellum at elevated solids loadings.

A lysate proteome engineering strategy for enhancing cell-free metabolite production.

The Core Chemotaxis Proteins CheA1 and CheA4 Link Chemotaxis Signaling with Nitrogen Metabolism.

Five key aspects of metaproteomics as a tool to understand functional interactions in host-associated microbiomes.

Respiratory Vinyl Chloride Reductive Dechlorination to Ethene in TceA-Expressing .

Microbiota functional activity biosensors for characterizing nutrient metabolism in vivo.

Metabolism of syringyl lignin-derived compounds in Pseudomonas putida enables convergent production of 2-pyrone-4,6-dicarboxylic acid.

Stepping on the Gas to a Circular Economy: Accelerating Development of Carbon-Negative Chemical Production from Gas Fermentation.

Anaerobic Microbial Metabolism of Dichloroacetate.

Identification and characterization of proteins of unknown function (PUFs) in Clostridium thermocellum DSM 1313 strains as potential genetic engineering targets.

Formation, characterization and modeling of emergent synthetic microbial communities.

Genomic reconstruction of fossil and living microorganisms in ancient Siberian permafrost.

Genetic and behavioral adaptation of Candida parapsilosis to the microbiome of hospitalized infants revealed by in situ genomics, transcriptomics, and proteomics.

Towards engineering ectomycorrhization into switchgrass bioenergy crops via a lectin receptor-like kinase.