Radiology Department
Dr. Li is currently a research assistant professor in the Department of Otolaryngology at Vanderbilt University Medical Center. He obtained his M.D. degree from Fudan University in China, and Ph.D. degree in hearing and speech sciences from Vanderbilt University. He completed his residency training in otolaryngology in Shanghai Eye and ENT hospital. Dr. Li has been working in the field of otolaryngology for over 10 years. His research interests include neurolaryngology, voice disorder, hearing loss, and artificial intelligence. Most of his recent publications focus on the application of electrical stimulation to the laryngeal muscles as a treatment approach to vocal fold paralysis. He is currently working on an NIH-funded clinical trial to investigate using an implantable electrical stimulator in the treatment of bilateral vocal fold paralysis in humans. He is also interested in exploring a similar approach in the management of facial paralysis. In addition, he is now engaged in applying machine learning techniques in the detection and diagnosis of head and neck diseases.
MicroRNA-122 promotes proliferation, invasion and migration of renal cell carcinoma cells through the PI3K/Akt signaling pathway.
Asian Pacific journal of cancer prevention : APJCP , 2013 | Pubmed ID: 24175769
Comparative risk of new-onset diabetes mellitus for antihypertensive drugs: A network meta-analysis.
Journal of clinical hypertension (Greenwich, Conn.) Dec, 2017 | Pubmed ID: 29067768
Bladder cancer: detection and image quality compared among iShim, RESOLVE, and ss-EPI diffusion-weighted MR imaging with high b value at 3.0 T MRI.
Medicine Dec, 2017 | Pubmed ID: 29390388
PBX1 promotes the cell proliferation via JAK2/STAT3 signaling in clear cell renal carcinoma.
Biochemical and biophysical research communications 06, 2018 | Pubmed ID: 29678569
SCUBE2 inhibits the proliferation, migration and invasion of human non-small cell lung cancer cells through regulation of the sonic hedgehog signaling pathway.
Gene Sep, 2018 | Pubmed ID: 29883759
microRNA-203 promotes proliferation, differentiation, and migration of osteoblasts by upregulation of Msh homeobox 2.
Journal of cellular physiology 08, 2019 | Pubmed ID: 30854680
Knocking down miR-384 promotes growth and metastasis of osteosarcoma MG63 cells by targeting SLBP.
Artificial cells, nanomedicine, and biotechnology Dec, 2019 | Pubmed ID: 31007083
Incorporation of metal-organic frameworks into electrospun chitosan/poly (vinyl alcohol) nanofibrous membrane with enhanced antibacterial activity for wound dressing application.
International journal of biological macromolecules Apr, 2020 | Pubmed ID: 32353508
p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides.
International journal of nanomedicine , 2021 | Pubmed ID: 33469287
Deep learning applied to two-dimensional color Doppler flow imaging ultrasound images significantly improves diagnostic performance in the classification of breast masses: a multicenter study.
Chinese medical journal Jan, 2021 | Pubmed ID: 33617184
Low-dose carbon monoxide suppresses metastatic progression of disseminated cancer cells.
Cancer letters Oct, 2022 | Pubmed ID: 35868533
Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2004 | Pubmed ID: 15033930
Determinants of cardiac electrophysiological properties in mice.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing Aug, 2004 | Pubmed ID: 15273447
Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations.
Oncogene Jun, 2005 | Pubmed ID: 15824740
Stem/progenitor cells in mouse mammary gland development and breast cancer.
Journal of mammary gland biology and neoplasia Jan, 2005 | Pubmed ID: 15886883
Keratin 6 is not essential for mammary gland development.
Breast cancer research : BCR , 2006 | Pubmed ID: 16790075
A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2006 | Pubmed ID: 17085580
Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2006 | Pubmed ID: 17090666
Wnt-1 is dominant over neu in specifying mammary tumor expression profiles.
Technology in cancer research & treatment Dec, 2006 | Pubmed ID: 17121432
RCAS-TVA in the mammary gland: an in vivo oncogene screen and a high fidelity model for breast transformation?
Cell cycle (Georgetown, Tex.) Apr, 2007 | Pubmed ID: 17377492
Comparison of expression profiles of metastatic versus primary mammary tumors in MMTV-Wnt-1 and MMTV-Neu transgenic mice.
Neoplasia (New York, N.Y.) Feb, 2008 | Pubmed ID: 18283333
Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors.
Neoplasia (New York, N.Y.) Jul, 2008 | Pubmed ID: 18592025
Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis.
Molecular cancer Mar, 2009 | Pubmed ID: 19267898
STAT5 confers lactogenic properties in breast tumorigenesis and restricts metastatic potential.
Oncogene Nov, 2022 | Pubmed ID: 36261627
The RCAS-TVA system for introduction of oncogenes into selected somatic mammary epithelial cells in vivo.
Journal of mammary gland biology and neoplasia Dec, 2009 | Pubmed ID: 19936988
Lentivirus vectors for stably introducing genes into mammary epithelial cells in vivo.
Journal of mammary gland biology and neoplasia Dec, 2009 | Pubmed ID: 19936990
Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2010 | Pubmed ID: 20133707
Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones.
Developmental biology Oct, 2010 | Pubmed ID: 20691178
Somatic expression of PyMT or activated ErbB2 induces estrogen-independent mammary tumorigenesis.
Neoplasia (New York, N.Y.) Sep, 2010 | Pubmed ID: 20824048
Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened.
Developmental biology Apr, 2011 | Pubmed ID: 21276786
Oncogene-induced senescence and its role in tumor suppression.
Journal of mammary gland biology and neoplasia Sep, 2011 | Pubmed ID: 21681694
ID4 regulates mammary gland development by suppressing p38MAPK activity.
Development (Cambridge, England) Dec, 2011 | Pubmed ID: 22069192
Stem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration.
PloS one , 2011 | Pubmed ID: 22140470
Mammary cells with active Wnt signaling resist ErbB2-induced tumorigenesis.
PloS one , 2013 | Pubmed ID: 24265712
Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy.
eLife Dec, 2013 | Pubmed ID: 24381245
Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2014 | Pubmed ID: 24395789
NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis.
Cancer research Jul, 2014 | Pubmed ID: 24769444
A p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis.
Molecular cancer research : MCR Feb, 2015 | Pubmed ID: 25253740
Inhibition of p70 S6 kinase (S6K1) activity by A77 1726 and its effect on cell proliferation and cell cycle progress.
Neoplasia (New York, N.Y.) Oct, 2014 | Pubmed ID: 25379019
Krt6a-positive mammary epithelial progenitors are not at increased vulnerability to tumorigenesis initiated by ErbB2.
PloS one , 2015 | Pubmed ID: 25635772
The Status of STAT3 and STAT5 in Human Breast Atypical Ductal Hyperplasia.
PloS one , 2015 | Pubmed ID: 26146825
Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation.
Cell reports Jul, 2015 | Pubmed ID: 26166574
NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α- and AP-1-mediated VEGFa transcription.
Oncotarget Sep, 2015 | Pubmed ID: 26287601
Generation and characterization of a breast carcinoma model by PyMT overexpression in mammary epithelial cells of tree shrew, an animal close to primates in evolution.
International journal of cancer Feb, 2016 | Pubmed ID: 26296387
Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies.
European journal of cancer (Oxford, England : 1990) Dec, 2015 | Pubmed ID: 26589974
Bcl-xL promotes metastasis independent of its anti-apoptotic activity.
Nature communications Jan, 2016 | Pubmed ID: 26785948
The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met.
Oncotarget Mar, 2016 | Pubmed ID: 26859575
Targeting Oncogenes into a Defined Subset of Mammary Cells Demonstrates That the Initiating Oncogenic Mutation Defines the Resulting Tumor Phenotype.
International journal of biological sciences , 2016 | Pubmed ID: 27019623
Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation.
Nature cell biology Jun, 2016 | Pubmed ID: 27183469
Xanthine oxidoreductase is required for genotoxic stress-induced NKG2D ligand expression and gemcitabine-mediated antitumor activity.
Oncotarget Sep, 2016 | Pubmed ID: 27494876
Transurethral biopsy of the prostatic urethra is associated with final apical margin status at radical cystoprostatectomy.
Journal of clinical urology Nov, 2016 | Pubmed ID: 27818773
Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.
American journal of physiology. Endocrinology and metabolism Mar, 2017 | Pubmed ID: 27894063
APP modulates KCC2 expression and function in hippocampal GABAergic inhibition.
eLife Jan, 2017 | Pubmed ID: 28054918
Inhibition of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation.
Oncotarget May, 2017 | Pubmed ID: 28389629
A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis.
Neoplasia (New York, N.Y.) May, 2017 | Pubmed ID: 28433771
Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2017 | Pubmed ID: 28874583
Breast tumor cell-specific knockout of inhibits cancer cell plasticity, dissemination, and lung metastasis in mice.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2017 | Pubmed ID: 29073077
The histone demethylase Kdm3a is required for normal epithelial proliferation, ductal elongation and tumor growth in the mouse mammary gland.
Oncotarget Oct, 2017 | Pubmed ID: 29156681
Sonic Hedgehog Signaling in Thyroid Cancer.
Frontiers in endocrinology , 2017 | Pubmed ID: 29163356
LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2018 | Pubmed ID: 29269400
Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates.
Cell death & disease Mar, 2018 | Pubmed ID: 29540819
Gingerenone A Sensitizes the Insulin Receptor and Increases Glucose Uptake by Inhibiting the Activity of p70 S6 Kinase.
Molecular nutrition & food research Dec, 2018 | Pubmed ID: 30296358
Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes.
Cancer research 01, 2019 | Pubmed ID: 30401712
ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions.
Nature cell biology Feb, 2019 | Pubmed ID: 30664791
Heterozygosity mapping for human dominant trait variants.
Human mutation Jul, 2019 | Pubmed ID: 31018026
PTPN3 acts as a tumor suppressor and boosts TGF-β signaling independent of its phosphatase activity.
The EMBO journal 07, 2019 | Pubmed ID: 31304624
Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms.
Nature cell biology 09, 2019 | Pubmed ID: 31451770
A POMC-originated circuit regulates stress-induced hypophagia, depression, and anhedonia.
Molecular psychiatry 05, 2020 | Pubmed ID: 31485012
Metformin and an insulin/IGF-1 receptor inhibitor are synergistic in blocking growth of triple-negative breast cancer.
Breast cancer research and treatment Jan, 2021 | Pubmed ID: 32940848
Intraductal Injection of Lentivirus Vectors for Stably Introducing Genes into Rat Mammary Epithelial Cells in Vivo.
Journal of mammary gland biology and neoplasia Dec, 2020 | Pubmed ID: 33165800
Author Correction: ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions.
Nature cell biology Mar, 2021 | Pubmed ID: 33531669
The bone microenvironment invigorates metastatic seeds for further dissemination.
Cell Apr, 2021 | Pubmed ID: 33878291
Cell lineage tracing links ERα loss in Erbb2-positive breast cancers to the arising of a highly aggressive breast cancer subtype.
Proceedings of the National Academy of Sciences of the United States of America May, 2021 | Pubmed ID: 34006643
A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis.
Cancer research Sep, 2021 | Pubmed ID: 34099494
Functional impact of cancer patient-associated Bcl-xL mutations.
MedComm Dec, 2020 | Pubmed ID: 34308416
Targeting the Pro-survival Protein BCL-2 to Prevent Breast Cancer.
Cancer prevention research (Philadelphia, Pa.) Jan, 2022 | Pubmed ID: 34667127
RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.
The Journal of clinical investigation Jan, 2022 | Pubmed ID: 34847079
Common Genomic Aberrations in Mouse and Human Breast Cancers with Concurrent P53 Deficiency and Activated PTEN-PI3K-AKT Pathway.
International journal of biological sciences , 2022 | Pubmed ID: 34975329
High-throughput profiling of histone post-translational modifications and chromatin modifying proteins by reverse phase protein array.
Journal of proteomics Jun, 2022 | Pubmed ID: 35489683
A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer Aug, 2022 | Pubmed ID: 35500836
Short-term PI3K Inhibition Prevents Breast Cancer in Preclinical Models.
Cancer prevention research (Philadelphia, Pa.) Feb, 2023 | Pubmed ID: 36343340
Generation of a tree shrew breast cancer model using lentivirus expressing - .
Zoological research Jan, 2023 | Pubmed ID: 36376241
Laparoscopic radiofrequency ablation for traumatic splenic rupture.
The Journal of surgical research Dec, 2013 | Pubmed ID: 23859132
FZR1 as a novel biomarker for breast cancer neoadjuvant chemotherapy prediction.
Cell death & disease Sep, 2020 | Pubmed ID: 32978372
DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer.
Cell death & disease Feb, 2022 | Pubmed ID: 35165262
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