Leon J. Schurgers

Differential lipoprotein transport pathways of K-vitamins in healthy subjects.

Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men.

Characteristics and performance of an immunosorbent assay for human matrix Gla-protein.

Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification.

Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats.

The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification.

Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice.

Matrix Gla-protein: the calcification inhibitor in need of vitamin K.

Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients.

Association of kidney function and uncarboxylated matrix Gla protein: data from the Heart and Soul Study.

The association of uncarboxylated matrix Gla protein with mitral annular calcification differs by diabetes status: The Heart and Soul study.

Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans.

The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study.

Calcium scores and matrix Gla protein levels: association with vitamin K status.

Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species.

Arterial calcifications.

Circulating nonphosphorylated carboxylated matrix gla protein predicts survival in ESRD.

Microcalcifications in early intimal lesions of atherosclerotic human coronary arteries.

Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum.

Patients using vitamin K antagonists show increased levels of coronary calcification: an observational study in low-risk atrial fibrillation patients.

Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight.

Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects.

Vitamin K intake and status are low in hemodialysis patients.

Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype.

Molecular imaging to identify the vulnerable plaque--from basic research to clinical practice.

Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: generation of antibodies against the thrombin-sensitive region of murine protein S.

Vitamin k intake and plasma desphospho-uncarboxylated matrix Gla-protein levels in kidney transplant recipients.

Mechanisms of arterial remodeling: lessons from genetic diseases.

Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization.

Vitamin K: key vitamin in controlling vascular calcification in chronic kidney disease.

The realm of vitamin K dependent proteins: shifting from coagulation toward calcification.

AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice.

Differential cellular effects of old and new oral anticoagulants: consequences to the genesis and progression of atherosclerosis.

Vascular smooth muscle cell calcification is mediated by regulated exosome secretion.

Prevention of vasculopathy by vitamin K supplementation: can we turn fiction into fact?

Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet.

High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of Extraosseous Calcification.

What's in a name? The pharmacy of vitamin K.

Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial).

Intra-Section Analysis of Human Coronary Arteries Reveals a Potential Role for Micro-Calcifications in Macrophage Recruitment in the Early Stage of Atherosclerosis.

New Insights into the Pros and Cons of the Clinical Use of Vitamin K Antagonists (VKAs) Versus Direct Oral Anticoagulants (DOACs).

Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice.

Does statins promote vascular calcification in chronic kidney disease?

Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study.

Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype.

Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment.

Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging.

Desphospho-Uncarboxylated Matrix-Gla Protein Is Increased Postoperatively in Cardiovascular Risk Patients.

Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study.

Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design.

Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling.

Decreased Levels of Circulating Carboxylated Osteocalcin in Children with Low Energy Fractures: A Pilot Study.

A Novel Biomimetic Tool for Assessing Vitamin K Status Based on Molecularly Imprinted Polymers.

Renal matrix Gla protein expression increases progressively with CKD and predicts renal outcome.

Missense mutation of VKORC1 leads to medial arterial calcification in rats.

Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon.

Vitamin K deficiency in critical ill patients; a prospective observational study.

Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults.

Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy.

Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease.

The Bone-Vasculature Axis: Calcium Supplementation and the Role of Vitamin K.

Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice.

Vitamin K Antagonists, Non-Vitamin K Antagonist Oral Anticoagulants, and Vascular Calcification in Patients with Atrial Fibrillation.

A Combination of seeds and Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity.

Pharmacological and Nutritional Modulation of Vascular Calcification.

Vitamin K Antagonist Use and Risk for Intracranial Carotid Artery Calcification in Patients With Intracerebral Hemorrhage.

Cheese and Healthy Diet: Associations With Incident Cardio-Metabolic Diseases and All-Cause Mortality in the General Population.

Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease.

Early vascular ageing in chronic kidney disease: impact of inflammation, vitamin K, senescence and genomic damage.

Matrix Gla protein is an independent predictor of both intimal and medial vascular calcification in chronic kidney disease.

Sevelamer Use in End-Stage Kidney Disease (ESKD) Patients Associates with Poor Vitamin K Status and High Levels of Gut-Derived Uremic Toxins: A Drug-Bug Interaction?

Intimal and medial calcification in relation to cardiovascular risk factors.

Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes?

Combined low vitamin D and K status amplifies mortality risk: a prospective study.

Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019.

Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78 (Glucose-Regulated Protein, 78 kDa)-Loaded Extracellular Vesicles.

Functional vitamin K status and risk of incident chronic kidney disease and microalbuminuria: a prospective general population-based cohort study.

γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K-dependent proteins.

Sodium [F]Fluoride PET Can Efficiently Monitor In Vivo Atherosclerotic Plaque Calcification Progression and Treatment.

Menaquinone-7 Supplementation Improves Osteogenesis in Pluripotent Stem Cell Derived Mesenchymal Stem Cells.

Locking and loading the bullet against micro-calcification.

Functional vitamin K insufficiency, vascular calcification and mortality in advanced chronic kidney disease: A cohort study.

Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate.

Effects of Combined Vitamin K2 and Vitamin D3 Supplementation on Na[F]F PET/MRI in Patients with Carotid Artery Disease: The INTRICATE Rationale and Trial Design.

Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling.

Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification.

Vitamin K and cardiovascular complications in chronic kidney disease patients.

Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity.

Hepatic and Vascular Vitamin K Status in Patients with High Cardiovascular Risk.

Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure.

Vitamin K-a neglected player in cardiovascular health: a narrative review.

Vascular Remodeling in Pulmonary Arterial Hypertension: The Potential Involvement of Innate and Adaptive Immunity.

Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells.

Improved Quantification of Cell Density in the Arterial Wall-A Novel Nucleus Splitting Approach Applied to 3D Two-Photon Laser-Scanning Microscopy.

Dietary magnesium supplementation inhibits abdominal vascular calcification in an experimental animal model of chronic kidney disease.

Vitamin K Supplementation in Chronic Kidney Disease Patients: Where is the Evidence?

Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification.

Prenatal administration of multipotent adult progenitor cells modulates the systemic and cerebral immune response in an ovine model of chorioamnionitis.