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Department of Neurology
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Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules.
Human molecular genetics Nov, 2010 | Pubmed ID: 20699327
Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets.
CNS & neurological disorders drug targets Dec, 2010 | Pubmed ID: 20942785
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.
Nature neuroscience Nov, 2010 | Pubmed ID: 20953194
Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics.
Molecular neurodegeneration Aug, 2013 | Pubmed ID: 24090136
Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis.
The Journal of biological chemistry Oct, 2014 | Pubmed ID: 25164820
Functions of FUS/TLS from DNA repair to stress response: implications for ALS.
ASN neuro Jun, 2014 | Pubmed ID: 25289647
Structural basis for mutation-induced destabilization of profilin 1 in ALS.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2015 | Pubmed ID: 26056300
ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation.
Scientific reports 03, 2017 | Pubmed ID: 28273913
Translation dysregulation in neurodegenerative disorders.
Proceedings of the National Academy of Sciences of the United States of America 12, 2018 | Pubmed ID: 30504142
The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for mRNA processing.
The Journal of biological chemistry 06, 2019 | Pubmed ID: 31092554
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway.
Nature neuroscience 08, 2021 | Pubmed ID: 34059832
ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization.
Proceedings of the National Academy of Sciences of the United States of America 06, 2021 | Pubmed ID: 34074767
Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons.
Neuron 05, 2022 | Pubmed ID: 35276083
Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons.
International journal of molecular sciences Dec, 2022 | Pubmed ID: 36555655
Interactions between FUS and the C-terminal Domain of Nup62 are Sufficient for their Co-phase Separation into Amorphous Assemblies.
Journal of molecular biology Mar, 2023 | Pubmed ID: 36690069
University of Massachusetts Chan Medical School
Salome Funes1,2,
Daryl A. Bosco1
1Department of Neurology, University of Massachusetts Chan Medical School,
2Translation Science Program, Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School
Jianjun Zhong1,2,
Georgia Gunner3,
Nils Henninger1,
Dorothy P. Schafer3,
2Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University,
3Department of Neurobiology, University of Massachusetts Chan Medical School
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