Department of Translational Medicine
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Apoptosis-like death in bacteria induced by HAMLET, a human milk lipid-protein complex.
PloS one Mar, 2011 | Pubmed ID: 21423701
Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease.
Frontiers in cellular and infection microbiology , 2014 | Pubmed ID: 25629011
Novel Strategy To Protect against Influenza Virus-Induced Pneumococcal Disease without Interfering with Commensal Colonization.
Infection and immunity 06, 2016 | Pubmed ID: 27001538
Directed vaccination against pneumococcal disease.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2016 | Pubmed ID: 27274071
In situ pneumococcal vaccine production and delivery through a hybrid biological-biomaterial vector.
Science advances Jul, 2016 | Pubmed ID: 27419235
Host Physiologic Changes Induced by Influenza A Virus Lead to Staphylococcus aureus Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease.
mBio 08, 2016 | Pubmed ID: 27507829
In Vitro and In Vivo Biofilm Formation by Pathogenic Streptococci.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 27914087
Low NF-κB Activation and Necroptosis in Alveolar Macrophages: A New Virulence Property of Streptococcus pneumoniae.
The Journal of infectious diseases 08, 2017 | Pubmed ID: 28368457
Panel 4: Report of the Microbiology Panel.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 04, 2017 | Pubmed ID: 28372529
Panel 6: Vaccines.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 04, 2017 | Pubmed ID: 28372533
Otitis Media Pathogenesis and How It Informs Our Understanding of Vaccine Strategies.
Current otorhinolaryngology reports , 2017 | Pubmed ID: 28616365
Modulates Biofilm Dispersion and the Transition from Colonization to Invasive Disease.
mBio 01, 2018 | Pubmed ID: 29317512
BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state.
PloS one , 2018 | Pubmed ID: 30157247
A Protein Complex from Human Milk Enhances the Activity of Antibiotics and Drugs against .
Antimicrobial agents and chemotherapy 02, 2019 | Pubmed ID: 30420480
Growing and Characterizing Biofilms Formed by Streptococcus pneumoniae.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 30929213
HAMLET, a protein complex from human milk has bactericidal activity and enhances the activity of antibiotics against pathogenic .
Antimicrobial agents and chemotherapy Oct, 2019 | Pubmed ID: 31591115
The human milk protein-lipid complex HAMLET disrupts glycolysis and induces death in .
The Journal of biological chemistry 12, 2019 | Pubmed ID: 31694917
A Role of Epithelial Cells and Virulence Factors in Biofilm Formation by Streptococcus pyogenes .
Infection and immunity 09, 2020 | Pubmed ID: 32661124
Niche- and Gender-Dependent Immune Reactions in Relation to the Microbiota Profile in Pediatric Patients with Otitis Media with Effusion.
Infection and immunity 09, 2020 | Pubmed ID: 32661126
HAMLET a human milk protein-lipid complex induces a pro-inflammatory phenotype of myeloid cells.
European journal of immunology 04, 2021 | Pubmed ID: 33348422
The serine protease HtrA plays a key role in heat-induced dispersal of pneumococcal biofilms.
Scientific reports 12, 2020 | Pubmed ID: 33384455
A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity upon Viral Infection and Advanced Age.
Infection and immunity 07, 2021 | Pubmed ID: 34031128
Capsule Independent Antimicrobial Activity Induced by Nanochitosan against .
Polymers Aug, 2021 | Pubmed ID: 34502964
Functional Antibodies Against SARS-CoV-2 Receptor Binding Domain Variants with Mutations N501Y or E484K in Human Milk from COVID-19-Vaccinated, -Recovered, and -Unvaccinated Women.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine 02, 2022 | Pubmed ID: 34809492
Influence of the Polysaccharide Capsule on the Bactericidal Activity of Indolicidin on S.
Frontiers in microbiology , 2022 | Pubmed ID: 35633685
Biofilms and Their Role in Disease Pathogenesis.
Frontiers in cellular and infection microbiology , 2022 | Pubmed ID: 35646720
A particulate matter: How environmental irritants and particulate matter increase sensitivity to bacterial respiratory tract infections. Commentary for "Underground railway particulate matter and susceptibility to pneumococcal infection".
EBioMedicine 07, 2022 | Pubmed ID: 35728486
Alexsandra Lenhard*,1,
Basma H. Joma*,2,3,
Nalat Siwapornchai2,
Anders P. Hakansson4,
John M. Leong2,5,
Elsa N. Bou Ghanem1
1Department of Microbiology and Immunology, University at Buffalo School of Medicine,
2Department of Molecular Biology and Microbiology, Tufts University School of Medicine,
3Graduate Program in Immunology, Tufts Graduate School of Biomedical Sciences,
4Department of Translational Medicine, Lund University,
5Stuart B. Levy Center for the Integrated Management of Antimicrobial Resistance, Tufts University
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