David A. Knecht

Kinetics of binding, uptake and degradation of live fluorescent (DsRed) bacteria by Dictyostelium discoideum.

Visualization of actin dynamics during macropinocytosis and exocytosis.

Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcgammaR, phagocytosis.

RacB regulates cytoskeletal function in Dictyostelium spp.

Cross-linking of actin filaments by myosin II is a major contributor to cortical integrity and cell motility in restrictive environments.

Silica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity.

Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis.

Metallothionein mediates leukocyte chemotaxis.

Under-agarose chemotaxis of Dictyostelium discoideum.

Automated real-time measurements of leukocyte chemotaxis.

Traction force microscopy in Dictyostelium reveals distinct roles for myosin II motor and actin-crosslinking activity in polarized cell movement.

Actin binding domains direct actin-binding proteins to different cytoskeletal locations.

Protein quaternary structure and expression levels contribute to peroxisomal-targeting-sequence-1-mediated peroxisomal import of human soluble epoxide hydrolase.

The phagocytosis of crystalline silica particles by macrophages.

tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis.

Incorporation of bovine serum albumin into biomimetic coatings on titanium with high loading efficacy and its release behavior.

Contribution of Filopodia to Cell Migration: A Mechanical Link between Protrusion and Contraction.

Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics.

The phagocytosis and toxicity of amorphous silica.

Macrophages phagocytose nonopsonized silica particles using a unique microtubule-dependent pathway.

Silica particles cause NADPH oxidase-independent ROS generation and transient phagolysosomal leakage.

Single Cell Analysis of Phagocytosis, Phagosome Maturation, Phagolysosomal Leakage, and Cell Death Following Exposure of Macrophages to Silica Particles.