The Feinstein Institute for Medical Research
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Globin attenuates the innate immune response to endotoxin.
Shock (Augusta, Ga.) Jun, 2002 | Pubmed ID: 12069185
HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion.
Cytokine May, 2002 | Pubmed ID: 12126646
Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation.
Nature Jan, 2003 | Pubmed ID: 12508119
Activation of gene expression in human neutrophils by high mobility group box 1 protein.
American journal of physiology. Cell physiology Apr, 2003 | Pubmed ID: 12620891
IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2003 | Pubmed ID: 12646658
HMGB1 as a cytokine and therapeutic target.
Journal of endotoxin research , 2002 | Pubmed ID: 12697092
Structural basis for the proinflammatory cytokine activity of high mobility group box 1.
Molecular medicine (Cambridge, Mass.) Jan-Feb, 2003 | Pubmed ID: 12765338
Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects.
Cytokine Dec, 2003 | Pubmed ID: 14609567
Reversing established sepsis with antagonists of endogenous high-mobility group box 1.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2004 | Pubmed ID: 14695889
Lipid unites disparate syndromes of sepsis.
Nature medicine Feb, 2004 | Pubmed ID: 14760415
Extracellular HMGB1 as a proinflammatory cytokine.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research Jun, 2004 | Pubmed ID: 15212706
Recombinant HMGB1 with cytokine-stimulating activity.
Journal of immunological methods Jun, 2004 | Pubmed ID: 15251426
Bench to bedside: HMGB1-a novel proinflammatory cytokine and potential therapeutic target for septic patients in the emergency department.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Aug, 2004 | Pubmed ID: 15289194
Pathogenic role of HMGB1 in SARS?
Medical hypotheses , 2004 | Pubmed ID: 15325019
Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms.
Journal of leukocyte biology Nov, 2004 | Pubmed ID: 15331624
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis.
Nature medicine Nov, 2004 | Pubmed ID: 15502843
Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis.
Journal of lipid research Apr, 2005 | Pubmed ID: 15687351
Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage.
Critical care medicine Feb, 2005 | Pubmed ID: 15699844
The cytokine activity of HMGB1.
Journal of leukocyte biology Jul, 2005 | Pubmed ID: 15734795
Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock.
The Journal of infectious diseases Sep, 2005 | Pubmed ID: 16107957
Interferon-gamma inhibition attenuates lethality after cecal ligation and puncture in rats: implication of high mobility group box-1.
Shock (Augusta, Ga.) Oct, 2005 | Pubmed ID: 16205327
More tea for septic patients?--Green tea may reduce endotoxin-induced release of high mobility group box 1 and other pro-inflammatory cytokines.
Medical hypotheses , 2006 | Pubmed ID: 16266789
The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis.
The Journal of nutrition Feb, 2006 | Pubmed ID: 16424112
Role of HMGB1 in cardiovascular diseases.
Current opinion in pharmacology Apr, 2006 | Pubmed ID: 16487750
Potential role of high mobility group box 1 in viral infectious diseases.
Viral immunology , 2006 | Pubmed ID: 16553546
Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia.
Shock (Augusta, Ga.) Jun, 2006 | Pubmed ID: 16721263
Role of HMGB1 in apoptosis-mediated sepsis lethality.
The Journal of experimental medicine Jul, 2006 | Pubmed ID: 16818669
HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.
Shock (Augusta, Ga.) Aug, 2006 | Pubmed ID: 16878026
Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1.
Journal of leukocyte biology Mar, 2007 | Pubmed ID: 17135572
A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2007 | Pubmed ID: 17339485
HMGB1 as a potential therapeutic target.
Novartis Foundation symposium , 2007 | Pubmed ID: 17380789
Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2007 | Pubmed ID: 17513788
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.
Blood Sep, 2007 | Pubmed ID: 17548579
The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2007 | Pubmed ID: 17617616
Adrenomedullin and adrenomedullin binding protein-1 prevent acute lung injury after gut ischemia-reperfusion.
Journal of the American College of Surgeons Aug, 2007 | Pubmed ID: 17660075
Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis.
Critical care medicine Dec, 2007 | Pubmed ID: 17901837
A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1.
PloS one , 2007 | Pubmed ID: 17987129
Alveolar macrophage suppression in sepsis is associated with high mobility group box 1 transmigration.
Shock (Augusta, Ga.) Jun, 2008 | Pubmed ID: 18004227
[Serum level of HMGB1 in patients with hepatitis B and its clinical significance].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Nov, 2007 | Pubmed ID: 18073062
A pilot study to detect high mobility group box 1 and heat shock protein 72 in cerebrospinal fluid of pediatric patients with meningitis.
Critical care medicine Jan, 2008 | Pubmed ID: 18090368
[The expression of fetuin-A and its pathological significance in fulminant hepatic failure in mice].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Jun, 2008 | Pubmed ID: 18578995
Hyperglycemia aggravates endotoxin-induced high mobility group box 1 protein release: yet another reason not to be too sweet.
Critical care medicine Aug, 2008 | Pubmed ID: 18664811
PACAP inhibit the release and cytokine activity of HMGB1 and improve the survival during lethal endotoxemia.
International immunopharmacology Dec, 2008 | Pubmed ID: 18713653
Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2008 | Pubmed ID: 18714026
Therapeutic potential of HMGB1-targeting agents in sepsis.
Expert reviews in molecular medicine , 2008 | Pubmed ID: 18980707
Caging a Beast in the Inflammation Arena: Use of Chinese Medicinal Herbs to Inhibit a Late Mediator of Lethal Sepsis, HMGB1.
International journal of clinical and experimental medicine , 2008 | Pubmed ID: 19079688
Ethyl pyruvate improves survival in awake hemorrhage.
Journal of molecular medicine (Berlin, Germany) Apr, 2009 | Pubmed ID: 19172241
Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function.
American journal of respiratory cell and molecular biology Dec, 2009 | Pubmed ID: 19265175
Novel HMGB1-inhibiting therapeutic agents for experimental sepsis.
Shock (Augusta, Ga.) Oct, 2009 | Pubmed ID: 19333143
Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats.
Critical care medicine Aug, 2009 | Pubmed ID: 19531942
Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers.
Molecular medicine (Cambridge, Mass.) Jul-Aug, 2009 | Pubmed ID: 19593412
High-mobility group box 1 protein induces tissue factor expression in vascular endothelial cells via activation of NF-kappaB and Egr-1.
Thrombosis and haemostasis Aug, 2009 | Pubmed ID: 19652887
Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII [corrected].
Journal of immunology (Baltimore, Md. : 1950) Nov, 2009 | Pubmed ID: 19812188
High mobility group box 1 protein as a potential drug target for infection- and injury-elicited inflammation.
Inflammation & allergy drug targets Mar, 2010 | Pubmed ID: 19906009
Peripheral administration of fetuin-A attenuates early cerebral ischemic injury in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Mar, 2010 | Pubmed ID: 19953099
[Effect of HMGB1 on human hepatoma cell line-HepG2 proliferation].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences May, 2010 | Pubmed ID: 20543468
A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2010 | Pubmed ID: 20547845
A hepatic protein, fetuin-A, occupies a protective role in lethal systemic inflammation.
PloS one , 2011 | Pubmed ID: 21347455
EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages.
Biochemical pharmacology May, 2011 | Pubmed ID: 21371444
HMGB1 cytoplasmic translocation in patients with acute liver failure.
BMC gastroenterology , 2011 | Pubmed ID: 21406085
Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats.
Molecular medicine (Cambridge, Mass.) Sep-Oct, 2011 | Pubmed ID: 21695352
Recombinant human MFG-E8 attenuates cerebral ischemic injury: its role in anti-inflammation and anti-apoptosis.
Neuropharmacology Feb, 2012 | Pubmed ID: 21964436
Anti-Inflammatory Role of Fetuin-A in Injury and Infection.
Current molecular medicine Jan, 2012 | Pubmed ID: 22292896
Inhibition of HMGB1 Enhances Bacterial Clearance and Protects against P. aeruginosa Pneumonia in Cystic Fibrosis.
Molecular medicine (Cambridge, Mass.) Feb, 2012 | Pubmed ID: 22314397
Exposure of perfluorononanoic acid suppresses the hepatic insulin signal pathway and increases serum glucose in rats.
Toxicology Apr, 2012 | Pubmed ID: 22387981
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