Yilun Sun

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability.

Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity.

Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC).

A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation.

A polymer index-matched to water enables diverse applications in fluorescence microscopy.

Autophagy-Dependent Sensitization of Triple-Negative Breast Cancer Models to Topoisomerase II Poisons by Inhibition of the Nucleosome Remodeling Factor.

Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress.

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation.

Functions of the CSB Protein at Topoisomerase 2 Inhibitors-Induced DNA Lesions.

Multiview confocal super-resolution microscopy.

Requirements for MRN endonuclease processing of topoisomerase II-mediated DNA damage in mammalian cells.