porcine-normothermic-isolated-liver-perfusion

Porcine Normothermic Isolated Liver Perfusion

Porcine models of liver ex situ normothermic machine perfusion (NMP) are increasingly being used in transplant research. Contrary to rodents, porcine ...

KU Leuven

University Hospitals Leuven

Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients.

To alleviate the persistent shortage of donor livers, high-risk liver grafts are increasingly being considered for liver transplantation. Conventional preservation with static cold storage falls short in protecting these high-risk livers from ischemia-reperfusion injury, as evident from higher rates of post-transplant complications such as early allograft dysfunction and ischemic cholangiopathy. Moreover, static cold storage does not allow for a functional assessment of the liver prior to transplantation. To overcome these limitations, dynamic strategies of liver preservation have been proposed, designed to provide a protective effect while allowing pre-transplant functional assessment. In this review, we discuss how different dynamic preservation strategies exert their effects, where we stand in assessing liver function and what challenges are lying ahead.

Dynamic liver preservation: Are we still missing pieces of the puzzle?

Prolonged organ procurement time impairs the outcome of donation after circulatory death (DCD) and liver transplantation (LiT). Our transplant team developed a simultaneous, rather than sequential, lung-abdominal organ explantation strategy for DCD donation to prioritize liver procurement. We evaluated whether this change in strategy effectively reduced donor hepatectomy time (dHT), without affecting donor pneumonectomy time (dPT), and influenced LiT and lung transplantation outcome.

Joris Blondeel

Department of Microbiology,
Immunology and Transplantation,
Laboratory of Abdominal Transplantation,
Department of Microbiology, Immunology and Transplantation, Laboratory of Abdominal Transplantation

KU Leuven

Porcine Normothermic Isolated Liver Perfusion

Joris Blondeel

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Microbiology,Immunology and Transplantation,Laboratory of Abdominal Transplantation,Department of Microbiology, Immunology and Transplantation, Laboratory of Abdominal Transplantation

KU Leuven

Porcine Normothermic Isolated Liver Perfusion

Department of Microbiology,
Immunology and Transplantation,
Laboratory of Abdominal Transplantation,
Department of Microbiology, Immunology and Transplantation, Laboratory of Abdominal Transplantation