Anne Vral

A semi‑automated FISH‑based micronucleus‑centromere assay for biomonitoring of hospital workers exposed to low doses of ionizing radiation.

In vitro evaluation of 213Bi-rituximab versus external gamma irradiation for the treatment of B-CLL patients: relative biological efficacy with respect to apoptosis induction and chromosomal damage.

Biologic dosimetry of 188Re-HDD/lipiodol versus 131I-lipiodol therapy in patients with hepatocellular carcinoma.

Chromosomal aberrations and in vitro radiosensitivity: intra-individual versus inter-individual variability.

Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes.

Effects of estradiol and progesterone on the variability of the micronucleus assay.

Chromosomal radiosensitivity of breast cancer with a CHEK2 mutation.

TGFbeta1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumors.

Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk.

Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity.

Single-nucleotide polymorphisms in DNA double-strand break repair genes: association with head and neck cancer and interaction with tobacco use and alcohol consumption.

A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure.

Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes.

Prediction of late normal tissue complications in RT treated gynaecological cancer patients: potential of the gamma-H2AX foci assay and association with chromosomal radiosensitivity.

Automated micronucleus (MN) scoring for population triage in case of large scale radiation events.

Lentivirus-mediated RNA interference of Ku70 to enhance radiosensitivity of human mammary epithelial cells.

The radiosensitizing effect of Ku70/80 knockdown in MCF10A cells irradiated with X-rays and p(66)+Be(40) neutrons.

Early increase of radiation-induced γH2AX foci in a human Ku70/80 knockdown cell line characterized by an enhanced radiosensitivity.

The micronucleus assay as a biological dosimeter of in vivo ionising radiation exposure.

Dose-length product of scanners correlates with DNA damage in patients undergoing contrast CT.

Variant ataxia telangiectasia: clinical and molecular findings and evaluation of radiosensitive phenotypes in a patient and relatives.

Early biomarkers related to secondary primary cancer risk in radiotherapy treated prostate cancer patients: IMRT versus IMAT.

MRI-guided 3D conformal arc micro-irradiation of a F98 glioblastoma rat model using the Small Animal Radiation Research Platform (SARRP).

Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling.

The influence of blood storage time and general anaesthesia on chromosomal radiosensitivity assessment.

Chromosomal radiosensitivity of human immunodeficiency virus positive/negative cervical cancer patients in South Africa.

BRCA1, BRCA2 and PALB2 mutations and CHEK2 c.1100delC in different South African ethnic groups diagnosed with premenopausal and/or triple negative breast cancer.

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation.

Multiparametric magnetic resonance imaging characteristics of normal, benign and malignant conditions in the prostate.

Capabilities of the RENEB network for research and large scale radiological and nuclear emergency situations.

RENEB accident simulation exercise.

Uncertainty of fast biological radiation dose assessment for emergency response scenarios.

In vitro cellular radiosensitivity in relationship to late normal tissue reactions in breast cancer patients: a multi-endpoint case-control study.

RENEB intercomparison exercises analyzing micronuclei (Cytokinesis-block Micronucleus Assay).

The harmonization process to set up and maintain an operational biological and physical retrospective dosimetry network: QA QM applied to the RENEB network.

The second gamma-H2AX assay inter-comparison exercise carried out in the framework of the European biodosimetry network (RENEB).

Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation.

Analysis of chromosomal radiosensitivity of healthy BRCA2 mutation carriers and non-carriers in BRCA families with the G2 micronucleus assay.

Diagnosis of Fanconi Anaemia by ionising radiation- or mitomycin C-induced micronuclei.

Accurate quantification of homologous recombination in zebrafish: brca2 deficiency as a paradigm.

Radiotherapy-activated cancer-associated fibroblasts promote tumor progression through paracrine IGF-1R activation.

Thorough in silico and in vitro cDNA analysis of 21 putative BRCA1 and BRCA2 splice variants and a complex tandem duplication in BRCA2 allowing the identification of activated cryptic splice donor sites in BRCA2 exon 11.

Accurate detection and quantification of epigenetic and genetic second hits in BRCA1 and BRCA2-associated hereditary breast and ovarian cancer reveals multiple co-acting second hits.

DNA double strand breaks induced by low dose mammography X-rays in breast tissue: A pilot study.

Dynamic changes in hippocampal diffusion and kurtosis metrics following experimental mTBI correlate with glial reactivity.

The HS-Releasing Naproxen Derivative ATB-346 and the Slow-Release HS Donor GYY4137 Reduce Intestinal Inflammation and Restore Transit in Postoperative Ileus.

Chromosomal radiosensitivity of triple negative breast cancer patients.

Green tea catechins for chemoprevention of prostate cancer in patients with histologically-proven HG-PIN or ASAP. Concise review and meta-analysis.

Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma: A preclinical F98 glioblastoma rat model study.

Fructosamine-3-Kinase as a Potential Treatment Option for Age-Related Macular Degeneration.

The Cytokinesis-Block Micronucleus Assay on Human Isolated Fresh and Cryopreserved Peripheral Blood Mononuclear Cells.

Intra-individual dynamic comparison of F-PSMA-11 and Ga-PSMA-11 in LNCaP xenograft bearing mice.

Zebrafish as an in vivo screening tool to establish PARP inhibitor efficacy.

The cytokinesis-block micronucleus assay for cryopreserved whole blood.

A Novel Non-Coding Variant in DCLRE1C Results in Deregulated Splicing and Induces SCID Through the Generation of a Truncated ARTEMIS Protein That Fails to Support V(D)J Recombination and DNA Damage Repair.

Impact of the molar activity and PSMA expression level on [F]AlF-PSMA-11 uptake in prostate cancer.

An updated view into the cell cycle kinetics of human T lymphocytes and the impact of irradiation.

A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues.

Preclinical comparative study of [F]AlF-PSMA-11 and [F]PSMA-1007 in varying PSMA expressing tumors.

DC vaccines loaded with glioma cells killed by photodynamic therapy induce Th17 anti-tumor immunity and provide a four-gene signature for glioma prognosis.

Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility.

Impact of proton therapy on the DNA damage induction and repair in hematopoietic stem and progenitor cells.

Peripheral blood lymphocytes differ in DNA damage response after exposure to X-rays with different physical properties.

A preclinical platform for assessing long-term drug efficacy exploiting mechanically tunable scaffolds colonized by a three-dimensional tumor microenvironment.

An improved F98 glioblastoma rat model to evaluate novel treatment strategies incorporating the standard of care.