Antje Heit

CpG-DNA aided cross-presentation of soluble antigens by dendritic cells.

Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells.

Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice.

CpG-DNA aided cross-priming by cross-presenting B cells.

Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: from expression profiling to a model of TLR signaling.

Targeting split vaccines to the endosome improves vaccination.

Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes.

Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines.

Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways.

Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO.

CpG motif-independent activation of TLR9 upon endosomal translocation of "natural" phosphodiester DNA.

Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells.

Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo.

NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs.

Antigen co-encapsulated with adjuvants efficiently drive protective T cell immunity.

Polylactide-coglycolide microspheres co-encapsulating recombinant tandem prion protein with CpG-oligonucleotide break self-tolerance to prion protein in wild-type mice and induce CD4 and CD8 T cell responses.

Vaccine protocols for enhanced immunogenicity of exogenous antigens.

Protective cancer immunotherapy: what can the innate immune system contribute?

TLR9 contributes to antiviral immunity during gammaherpesvirus infection.

The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation.

Circumvention of regulatory CD4(+) T cell activity during cross-priming strongly enhances T cell-mediated immunity.

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells.

Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes.

Sequence independent interferon-alpha induction by multimerized phosphodiester DNA depends on spatial regulation of Toll-like receptor-9 activation in plasmacytoid dendritic cells.

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation.

Immunostimulatory CpG-DNA and PSA-peptide vaccination elicits profound cytotoxic T cell responses.

Profiling immunity to HIV vaccines with systems biology.