Philippe Froguel

Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.

Activating mutations in the ABCC8 gene in neonatal diabetes mellitus.

Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women.

Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q.

Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes.

Genetics of obesity and the prediction of risk for health.

Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians.

Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.

Impact of a CART promoter genetic variation on plasma lipid profile in a general population.

TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study.

Genotype-by-nutrient interactions assessed in European obese women. A case-only study.

Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies.

No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases.

Comment on "A common genetic variant is associated with adult and childhood obesity".

Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women.

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.

A genome-wide association study identifies novel risk loci for type 2 diabetes.

Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits.

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.

Preadipocyte response and impairment of differentiation in an inflammatory environment.

Coexistence in the same family of both focal and diffuse forms of hyperinsulinism.

New ABCC8 mutations in relapsing neonatal diabetes and clinical features.

Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes.

TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis.

Variation in FTO contributes to childhood obesity and severe adult obesity.

Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene.

FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.

TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population.

Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity.

Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases.

Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.

Analysis of KLF transcription factor family gene variants in type 2 diabetes.

Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.

Lack of association between the Pro12Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous population.

Meta-analysis of genome-wide linkage studies in BMI and obesity.

Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences.

A single-nucleotide polymorphism in the p110beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents.

Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children.

Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study.

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity.

Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Study Group.

Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.

Effects of TCF7L2 polymorphisms on obesity in European populations.

Neonatal hyperglycaemia and abnormal development of the pancreas.

Evaluating the association of common PBX1 variants with type 2 diabetes.

R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population.

Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.

A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.

Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations.

INS VNTR is not associated with childhood obesity in 1,023 families: a family-based study.

Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans.

Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2).

Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians.

Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes.

TCF7L2 genetic defect and type 2 diabetes.

Inflammation is associated with a decrease of lipogenic factors in omental fat in women.

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.

Common genetic variation near MC4R is associated with waist circumference and insulin resistance.

Common variants near MC4R are associated with fat mass, weight and risk of obesity.

Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.

The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.

Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G>C.

The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.

Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.

Common nonsynonymous variants in PCSK1 confer risk of obesity.

Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).

The FTO gene is associated with adulthood obesity in the Mexican population.

The power of the extreme in elucidating obesity.

Small deletion variants have stable breakpoints commonly associated with alu elements.

Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose.

The Q121 variant of ENPP1 may protect from childhood overweight/obesity in the Italian population.

Is obesity our genetic legacy?

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.

Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).

Smallness for gestational age interacts with high mobility group A2 gene genetic variation to modulate height.

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity.

Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans.

Evaluating the association of common APOA2 variants with type 2 diabetes.

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.

ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease.

Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study.

A rare variant in the visfatin gene (NAMPT/PBEF1) is associated with protection from obesity.

G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.

Regulation of carboxylesterase 1 (CES1) in human adipose tissue.

Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study.

The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects.

Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.

Breakthroughs in monogenic diabetes genetics: from pediatric forms to young adulthood diabetes.

Common variation in SIM1 is reproducibly associated with BMI in Pima Indians.

A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism.

The genetic contribution to non-syndromic human obesity.

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Improved donor/acceptor BRET couples for monitoring beta-arrestin recruitment to G protein-coupled receptors.

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.

Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss.

Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians.

Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits.

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).

Prevalence of loss-of-function FTO mutations in lean and obese individuals.

MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells.

Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?

Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study.

Early detrimental metabolic outcomes of rs17300539-A allele of ADIPOQ gene despite higher adiponectinemia.

Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY).

[Inputs from the genetics of fasting glucose: lessons for diabetes].

Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention.

Genome-wide association study identifies five loci associated with lung function.

PLCL1 rs7595412 variation is not associated with hip bone size variation in postmenopausal Danish women.

TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet.

Evaluating the association of FAAH common gene variation with childhood, adult severe obesity and type 2 diabetes in the French population.

Analysis of the SIM1 contribution to polygenic obesity in the French population.

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population.

Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets.

Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population.

MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans.

Inflammatory role of Toll-like receptors in human and murine adipose tissue.

Evidence for leptin receptor isoforms heteromerization at the cell surface.

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.

Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.

cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs.

Monogenic forms of diabetes mellitus: an update.

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors.

Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.

Monogenic forms of diabetes mellitus: an update.

Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS.

Evaluation of A2BP1 as an obesity gene.

The emerging genetics of type 2 diabetes.

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Lack of association of CD36 SNPs with early onset obesity: a meta-analysis in 9,973 European subjects.

Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome.

Screening low-frequency SNPS from genome-wide association study reveals a new risk allele for progression to AIDS.

Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine.

Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations.

Childhood obesity is associated with shorter leukocyte telomere length.

TCF7L2 splice variants have distinct effects on beta-cell turnover and function.

Bio-Repository of DNA in stroke (BRAINS): a study protocol.

Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants.

Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway.

Chromosome 19p13.3 deletion in a patient with macrocephaly, obesity, mental retardation, and behavior problems.

Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children.

famCNV: copy number variant association for quantitative traits in families.

Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

Accurate single-nucleotide polymorphism allele assignment in trisomic or duplicated regions by using a single base-extension assay with MALDI-TOF mass spectrometry.

Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population.

Systems medicine and integrated care to combat chronic noncommunicable diseases.

Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity.

Characterization of the human SLC30A8 promoter and intronic enhancer.

ITIH-5 expression in human adipose tissue is increased in obesity.

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.

Effects of genetic susceptibility for type 2 diabetes on the evolution of glucose homeostasis traits before and after diabetes diagnosis: data from the D.E.S.I.R. Study.

Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene.

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.

New gene functions in megakaryopoiesis and platelet formation.

Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity.

Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk.

Clinical and metabolic features of adult-onset diabetes caused by ABCC8 mutations.

A genome-wide association search for type 2 diabetes genes in African Americans.

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes.

Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.

Multicohort Genomewide Association Study Reveals a New Signal of Protection Against HIV-1 Acquisition.

A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron.

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.

Loss-of-function mutations in MC4R are very rare in the Greek severely obese adult population.

High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families.

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

A genome-wide association meta-analysis identifies new childhood obesity loci.

The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis.

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone.

Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity.

Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity.

The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size.

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.

Impact of common variation in bone-related genes on type 2 diabetes and related traits.

Whole-exome sequencing and high throughput genotyping identified KCNJ11 as the thirteenth MODY gene.

Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers.

Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms.

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

Response to comment on: Marquez et al. Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes 2012;61:524-530.

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts.

Seventy-five genetic loci influencing the human red blood cell.

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Adipose Tissue Resting Energy Expenditure and Expression of Genes Involved in Mitochondrial Function Are Higher in Women than in Men.