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Structural Biophysics Laboratory
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Bisimidazoacridones: 2. Steady-state and time-resolved fluorescence studies of their diverse interactions with DNA.
Photochemistry and photobiology Oct, 2003 | Pubmed ID: 14626657
Transmembrane inhibitors of P-glycoprotein, an ABC transporter.
Journal of medicinal chemistry Jun, 2005 | Pubmed ID: 15916428
Structural analogues of smoothened intracellular loops as potent inhibitors of Hedgehog pathway and cancer cell growth.
Journal of medicinal chemistry Sep, 2007 | Pubmed ID: 17685505
Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target.
ACS chemical biology Dec, 2007 | Pubmed ID: 18154267
Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2009 | Pubmed ID: 19255450
Engineered human antibody constant domains with increased stability.
The Journal of biological chemistry May, 2009 | Pubmed ID: 19307178
Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78.
Molecular cell Jun, 2009 | Pubmed ID: 19560420
Limitations of peptide retro-inverso isomerization in molecular mimicry.
The Journal of biological chemistry Jun, 2010 | Pubmed ID: 20382735
Peptide structure stabilization by membrane anchoring and its general applicability to the development of potent cell-permeable inhibitors.
Chembiochem : a European journal of chemical biology Apr, 2011 | Pubmed ID: 21365731
Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2011 | Pubmed ID: 21628584
The Era GTPase recognizes the GAUCACCUCC sequence and binds helix 45 near the 3' end of 16S rRNA.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2011 | Pubmed ID: 21646538
Structural basis for RNA recognition by NusB and NusE in the initiation of transcription antitermination.
Nucleic acids research Sep, 2011 | Pubmed ID: 21652641
Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA.
The Journal of biological chemistry Apr, 2012 | Pubmed ID: 22378781
β-Defensin 2 and 3 Promote the Uptake of Self or CpG DNA, Enhance IFN-α Production by Human Plasmacytoid Dendritic Cells, and Promote Inflammation.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2013 | Pubmed ID: 23776172
Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine.
The EMBO journal Aug, 2013 | Pubmed ID: 23942235
National Cancer Institute
Lyuba Khavrutskii1,2,
Joanna Yeh1,
Olga Timofeeva3,
Sergey G. Tarasov4,
Samuel Pritt1,
Karen Stefanisko1,
Nadya Tarasova1
1Cancer and Inflammation Program, National Cancer Institute,
2Basic Science Program, SAIC-Frederick, Inc.,
3Departments of Oncology and Radiation Medicine, Georgetown University Medical Center,
4Structural Biophysics Laboratory, National Cancer Institute
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