Wolf Reik

Safeguarding parental identity: Dnmt1 maintains imprints during epigenetic reprogramming in early embryogenesis.

Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.

Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians.

Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5.

Dynamic reprogramming of DNA methylation in the early mouse embryo.

Disruption of mesodermal enhancers for Igf2 in the minute mutant.

Placental overgrowth in mice lacking the imprinted gene Ipl.

Placental-specific IGF-II is a major modulator of placental and fetal growth.

Replication timing properties within the mouse distal chromosome 7 imprinting cluster.

Epigenetic reprogramming in mouse primordial germ cells.

Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancer.

Back to the beginning.

Evidence that paternal expression of the epsilon-sarcoglycan gene accounts for reduced penetrance in myoclonus-dystonia.

Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer.

Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse.

Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions.

Regulation of supply and demand for maternal nutrients in mammals by imprinted genes.

The need for Eed.

Gene expression: Silent clones speak up.

Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos.

Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12.

Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment?

Paternal imprints can be established on the maternal Igf2-H19 locus without altering replication timing of DNA.

An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype.

Genomic imprinting controls matrix attachment regions in the Igf2 gene.

Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region.

Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops.

Active genes dynamically colocalize to shared sites of ongoing transcription.

Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming.

Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation.

Resourceful imprinting.

The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster.

Dynamic chromatin modifications characterise the first cell cycle in mouse embryos.

Epigenetic reprogramming in mammals.

Co-evolution of X-chromosome inactivation and imprinting in mammals.

Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans.

Molecular subtypes and phenotypic expression of Beckwith-Wiedemann syndrome.

Mice deficient in APOBEC2 and APOBEC3.

Developmental biology: the X-inactivation yo-yo.

Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems.

CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2.

Artificial sperm and epigenetic reprogramming.

Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.

A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA.

Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote.

Stability and flexibility of epigenetic gene regulation in mammalian development.

Non-coding transcripts in the H19 imprinting control region mediate gene silencing in transgenic Drosophila.

Clinical and molecular genetic features of Beckwith-Wiedemann syndrome associated with assisted reproductive technologies.

DNA demethylation by DNA repair.

The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing.

Evolution and functions of long noncoding RNAs.

Germline mutation in NLRP2 (NALP2) in a familial imprinting disorder (Beckwith-Wiedemann Syndrome).

Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal.

Raised late pregnancy glucose concentrations in mice carrying pups with targeted disruption of H19delta13.

Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.

Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.

Wolf Reik: Inheritance beyond DNA. Interview by Nicole Lebrasseur.

Evaluation of epigenetic marks in human embryos derived from IVF and ICSI.

Retrotransposons and germ cells: reproduction, death, and diversity.

Epigenetic reprogramming in plant and animal development.

Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth.

Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating glucose concentrations.

5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming.

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.

DNA demethylases: a new epigenetic frontier in drug discovery.

Uncovering the role of 5-hydroxymethylcytosine in the epigenome.

BLUEPRINT to decode the epigenetic signature written in blood.

Methylome analysis using MeDIP-seq with low DNA concentrations.

Shifting behaviour: epigenetic reprogramming in eusocial insects.

Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution.

The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r.

Pairing of homologous regions in the mouse genome is associated with transcription but not imprinting status.

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase.

Incomplete methylation reprogramming in SCNT embryos.

Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline.

Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers.

The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells.

Direct sequencing of small genomes on the Pacific Biosciences RS without library preparation.

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.

Conceptual links between DNA methylation reprogramming in the early embryo and primordial germ cells.

Reprogramming by cell fusion: boosted by Tets.

Dnmt2-dependent methylomes lack defined DNA methylation patterns.

Regulation of lineage specific DNA hypomethylation in mouse trophectoderm.

FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency.