Division of Pediatric Hematology/Oncology/Stem Cell Transplantation
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Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2002 | Pubmed ID: 11959990
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2002 | Pubmed ID: 12397173
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification.
Cancer cell Feb, 2003 | Pubmed ID: 12620411
Polyubiquitination of p53 by a ubiquitin ligase activity of p300.
Science (New York, N.Y.) Apr, 2003 | Pubmed ID: 12690203
Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2.
Nature structural biology Jul, 2003 | Pubmed ID: 12778114
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2003 | Pubmed ID: 14595012
Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination.
Molecular imaging Oct, 2003 | Pubmed ID: 14717328
Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.
Cancer cell Mar, 2004 | Pubmed ID: 15050914
p53 targets simian virus 40 large T antigen for acetylation by CBP.
Journal of virology Aug, 2004 | Pubmed ID: 15254196
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.
Cancer cell Jul, 2004 | Pubmed ID: 15261140
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
Science (New York, N.Y.) Sep, 2004 | Pubmed ID: 15353804
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.
Cancer cell Feb, 2005 | Pubmed ID: 15710326
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing.
Genes & development Feb, 2005 | Pubmed ID: 15713842
Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism.
The Journal of biological chemistry Aug, 2005 | Pubmed ID: 15951563
A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.
PLoS genetics Jul, 2005 | Pubmed ID: 16103922
In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging.
Cancer research Sep, 2005 | Pubmed ID: 16166309
Antimyeloma activity of heat shock protein-90 inhibition.
Blood Feb, 2006 | Pubmed ID: 16234364
Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies.
Cancer research Dec, 2005 | Pubmed ID: 16357147
Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and antiangiogenic treatment effect.
Neurosurgery Feb, 2006 | Pubmed ID: 16462491
Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2006 | Pubmed ID: 16638967
A novel noninvasive model of endometriosis for monitoring the efficacy of antiangiogenic therapy.
The American journal of pathology Jun, 2006 | Pubmed ID: 16723720
Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.
Cancer cell Jun, 2006 | Pubmed ID: 16766266
Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias.
Blood Mar, 2007 | Pubmed ID: 17068153
Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity.
Gastroenterology Dec, 2006 | Pubmed ID: 17087936
Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma.
Blood Apr, 2007 | Pubmed ID: 17119115
CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research Nov, 2006 | Pubmed ID: 17121897
Targeting the AIB1 oncogene through mammalian target of rapamycin inhibition in the mammary gland.
Cancer research Dec, 2006 | Pubmed ID: 17145884
Practices and pitfalls of mouse cancer models in drug discovery.
Advances in cancer research , 2007 | Pubmed ID: 17161681
Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.
PLoS medicine Apr, 2007 | Pubmed ID: 17425403
Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells.
Molecular cancer therapeutics Jul, 2007 | Pubmed ID: 17620426
Therapeutic targeting of apoptosis pathways in cancer.
Current opinion in oncology Jan, 2008 | Pubmed ID: 18043263
Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells.
Blood Apr, 2008 | Pubmed ID: 18184863
Anti-apoptosis mechanisms in malignant gliomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Jan, 2008 | Pubmed ID: 18202424
Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation.
Human molecular genetics Jun, 2008 | Pubmed ID: 18319327
Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells.
Molecular cancer therapeutics May, 2008 | Pubmed ID: 18445657
Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2008 | Pubmed ID: 18607002
The requirement for cyclin D function in tumor maintenance.
Cancer cell Oct, 2012 | Pubmed ID: 23079655
Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage.
Pigment cell & melanoma research Aug, 2008 | Pubmed ID: 18627530
Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins.
The Journal of clinical investigation Sep, 2008 | Pubmed ID: 18677408
Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells.
Blood Dec, 2008 | Pubmed ID: 18820131
H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Cancer cell Nov, 2008 | Pubmed ID: 18977325
Desferroxamine infusion increases cerebral blood flow: a potential association with hypoxia-inducible factor-1.
Clinical science (London, England : 1979) May, 2009 | Pubmed ID: 19014354
HOXA9 is required for survival in human MLL-rearranged acute leukemias.
Blood Mar, 2009 | Pubmed ID: 19056693
Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy.
Nature biotechnology Jan, 2009 | Pubmed ID: 19098899
Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo.
Neoplasia (New York, N.Y.) Jan, 2009 | Pubmed ID: 19107234
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.
Blood Apr, 2009 | Pubmed ID: 19139079
Lipocalin 2 promotes breast cancer progression.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2009 | Pubmed ID: 19237579
Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2009 | Pubmed ID: 19255431
The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity.
The Journal of biological chemistry May, 2009 | Pubmed ID: 19297328
Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer.
Journal of the National Cancer Institute Apr, 2009 | Pubmed ID: 19318631
Identification of AML1-ETO modulators by chemical genomics.
Blood Jun, 2009 | Pubmed ID: 19377049
HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice.
The Journal of clinical investigation Aug, 2009 | Pubmed ID: 19662677
In vivo pharmacodynamic imaging of proteasome inhibition.
Molecular imaging May-Jun, 2009 | Pubmed ID: 19723471
Proteomic and genetic approaches identify Syk as an AML target.
Cancer cell Oct, 2009 | Pubmed ID: 19800574
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2009 | Pubmed ID: 19805293
Systematic in vivo structure-function analysis of p300 in hematopoiesis.
Blood Nov, 2009 | Pubmed ID: 19822904
Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia.
Genome biology , 2009 | Pubmed ID: 19828020
Direct inhibition of the NOTCH transcription factor complex.
Nature Nov, 2009 | Pubmed ID: 19907488
An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells.
Cancer cell Mar, 2010 | Pubmed ID: 20227043
Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity.
Nature medicine Apr, 2010 | Pubmed ID: 20228816
Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants.
Blood May, 2010 | Pubmed ID: 20299508
Discovery and characterization of novel mutant FLT3 kinase inhibitors.
Molecular cancer therapeutics Sep, 2010 | Pubmed ID: 20807780
Selective inhibition of BET bromodomains.
Nature Dec, 2010 | Pubmed ID: 20871596
Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene.
Cancer research Dec, 2010 | Pubmed ID: 20952506
A stapled p53 helix overcomes HDMX-mediated suppression of p53.
Cancer cell Nov, 2010 | Pubmed ID: 21075307
Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas.
Journal of neuro-oncology Aug, 2011 | Pubmed ID: 21246394
Optical techniques for tracking multiple myeloma engraftment, growth, and response to therapy.
Journal of biomedical optics Jan-Feb, 2011 | Pubmed ID: 21280893
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Nature Mar, 2011 | Pubmed ID: 21368833
Differentiation of NUT midline carcinoma by epigenomic reprogramming.
Cancer research Apr, 2011 | Pubmed ID: 21447744
Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.
Blood Jul, 2011 | Pubmed ID: 21555743
A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo.
Neuro-oncology Aug, 2011 | Pubmed ID: 21724651
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.
Cancer cell Jul, 2011 | Pubmed ID: 21741596
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.
Cancer cell Jul, 2011 | Pubmed ID: 21741597
Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation.
PloS one , 2011 | Pubmed ID: 21750699
A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo.
Chemistry & biology Jul, 2011 | Pubmed ID: 21802004
High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.
The Journal of experimental medicine Aug, 2011 | Pubmed ID: 21807868
Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular endothelial growth factor receptor 2 expression and signaling in experimental endometriosis in vivo.
Fertility and sterility Oct, 2011 | Pubmed ID: 21821246
BET bromodomain inhibition as a therapeutic strategy to target c-Myc.
Cell Sep, 2011 | Pubmed ID: 21889194
Inactivation of a single copy of Crebbp selectively alters pre-mRNA processing in mouse hematopoietic stem cells.
PloS one , 2011 | Pubmed ID: 21901164
Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2011 | Pubmed ID: 21949374
P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment.
Blood Feb, 2012 | Pubmed ID: 22096244
Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm.
Experimental hematology Dec, 2011 | Pubmed ID: 22198154
Molecular and cellular effects of NEDD8-activating enzyme inhibition in myeloma.
Molecular cancer therapeutics Apr, 2012 | Pubmed ID: 22246439
Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma.
Blood Mar, 2012 | Pubmed ID: 22262760
Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition.
The Journal of experimental medicine Feb, 2012 | Pubmed ID: 22271575
Incongruity of imaging using fluorescent 2-DG conjugates compared to 18F-FDG in preclinical cancer models.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Oct, 2012 | Pubmed ID: 22302178
The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia.
The Journal of clinical investigation Mar, 2012 | Pubmed ID: 22326953
Anti-inflammatory properties of histone deacetylase inhibitors: a mechanistic study.
The journal of trauma and acute care surgery Feb, 2012 | Pubmed ID: 22327976
Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features.
Blood Jun, 2012 | Pubmed ID: 22394600
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.
Nature Mar, 2012 | Pubmed ID: 22425996
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency.
Cancer cell Apr, 2012 | Pubmed ID: 22516262
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.
The Journal of clinical investigation Jun, 2012 | Pubmed ID: 22622039
Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia.
Nature medicine Jul, 2012 | Pubmed ID: 22683780
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia.
Blood Oct, 2012 | Pubmed ID: 22904298
Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling.
Science translational medicine Aug, 2012 | Pubmed ID: 22914623
Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma.
Cancer cell Sep, 2012 | Pubmed ID: 22975378
In vivo imaging of inflammatory phagocytes.
Chemistry & biology Sep, 2012 | Pubmed ID: 22999887
In Vivo Fluorescent Labeling of Tumor Cells with the HaloTag® Technology.
Current chemical genomics , 2012 | Pubmed ID: 23115613
The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations.
Genes & cancer Jul, 2012 | Pubmed ID: 23264850
Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis.
Angiogenesis Jan, 2013 | Pubmed ID: 23334337
KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.
British journal of haematology Apr, 2013 | Pubmed ID: 23373539
Shikonin, a natural product from the root of Lithospermum erythrorhizon, is a cytotoxic DNA-binding agent.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Feb, 2013 | Pubmed ID: 23422689
Targeting MYCN in neuroblastoma by BET bromodomain inhibition.
Cancer discovery Mar, 2013 | Pubmed ID: 23430699
Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.
Cancer cell Mar, 2013 | Pubmed ID: 23434461
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF.
Cancer cell Mar, 2013 | Pubmed ID: 23477830
High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma.
Cancer research May, 2013 | Pubmed ID: 23536552
AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/β-catenin signaling pathway.
Blood Jun, 2013 | Pubmed ID: 23645839
Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation.
Chemistry & biology May, 2013 | Pubmed ID: 23706636
Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer.
Cancer discovery Aug, 2013 | Pubmed ID: 23715154
Differential Disruption of EWS-FLI1 Binding by DNA-Binding Agents.
PloS one , 2013 | Pubmed ID: 23894528
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