David P. Speert

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment.

Epidemiology of Burkholderia cepacia complex in patients with cystic fibrosis, Canada.

Differential persistence among genomovars of the Burkholderia cepacia complex in a murine model of pulmonary infection.

Burkholderia anthina sp. nov. and Burkholderia pyrrocinia, two additional Burkholderia cepacia complex bacteria, may confound results of new molecular diagnostic tools.

Multidrug efflux systems play an important role in the invasiveness of Pseudomonas aeruginosa.

Effect of Burkholderia cepacia infection in the clinical course of patients with cystic fibrosis: a pilot study in a Sydney clinic.

Molecular epidemiology of Pseudomonas aeruginosa.

Biofilm formation and acyl homoserine lactone production in the Burkholderia cepacia complex.

Evaluation of a diagnostic polymerase chain reaction assay for Neisseria meningitidis in North America and field experience during an outbreak.

Epidemiology of Pseudomonas aeruginosa in cystic fibrosis in British Columbia, Canada.

Colonial morphology of Burkholderia cepacia complex genomovar III: implications in exopolysaccharide production, pilus expression, and persistence in the mouse.

The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization.

The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes.

Primary immunodeficiency to pneumococcal infection due to a defect in Toll-like receptor signaling.

Detection and genotyping of varicella-zoster virus by TaqMan allelic discrimination real-time PCR.

Differential post-transcriptional activation of human phagocytes by different Pseudomonas aeruginosa isolates.

Burkholderia cepacia complex and cystic fibrosis: in search of the smoking gun.

Production of exopolysaccharide by Burkholderia cenocepacia results in altered cell-surface interactions and altered bacterial clearance in mice.

Persistence of Burkholderia multivorans within the pulmonary macrophage in the murine lung.

Burkholderia phenoliruptrix sp. nov., to accommodate the 2,4,5-trichlorophenoxyacetic acid and halophenol-degrading strain AC1100.

Burkholderia cenocepacia induces neutrophil necrosis in chronic granulomatous disease.

Identification of DNA markers for a transmissible Pseudomonas aeruginosa cystic fibrosis strain.

Viridans streptococci bacteremia in children with malignancy: relevance of species identification and penicillin susceptibility.

Pseudomonas aeruginosa: role in the pathogenesis of the CF lung lesion.

Chronic granulomatous disease: from genetic defect to clinical presentation.

Primary immune deficiencies presenting in adults: seven years of experience from Iran.

Multilocus sequence typing scheme that provides both species and strain differentiation for the Burkholderia cepacia complex.

Exopolysaccharides from Burkholderia cenocepacia inhibit neutrophil chemotaxis and scavenge reactive oxygen species.

Persistent bacteremia and severe thrombocytopenia caused by coagulase-negative Staphylococcus in a neonatal intensive care unit.

Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients.

IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells.

Reliability of multilocus sequence typing of the Burkholderia cepacia complex in cystic fibrosis.

Proteomic identification and characterization of bacterial factors associated with Burkholderia cenocepacia survival in a murine host.

Bacterial infections of the lung in normal and immunodeficient patients.

Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-kappa B.

Environmental Burkholderia cepacia complex isolates in human infections.

Unique lipid a modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis.

Recurrent systemic pneumococcal disease and IRAK4 deficiency.

Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing.

Differential mucoid exopolysaccharide production by members of the Burkholderia cepacia complex.

Differential modulation of innate immune cell functions by the Burkholderia cepacia complex: Burkholderia cenocepacia but not Burkholderia multivorans disrupts maturation and induces necrosis in human dendritic cells.

ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease.

Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp. nov. and Burkholderia lata sp. nov.

Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages.

Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity.

Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface.

The role of mucoidy in virulence of bacteria from the Burkholderia cepacia complex: a systematic proteomic and transcriptomic analysis.

Mucoid and nonmucoid Burkholderia cepacia complex bacteria in cystic fibrosis infections.

Toll-like receptor gene polymorphisms and preeclampsia risk: a case-control study and data synthesis.

Parallel evolution in Pseudomonas aeruginosa over 39,000 generations in vivo.

Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis.

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.

In vitro susceptibility of Burkholderia vietnamiensis to aminoglycosides.

In vivo-transmigrated human neutrophils are resistant to antiapoptotic stimulation.

Mucoid morphotype variation of Burkholderia multivorans during chronic cystic fibrosis lung infection is correlated with changes in metabolism, motility, biofilm formation and virulence.

Identification of hopanoid biosynthesis genes involved in polymyxin resistance in Burkholderia multivorans.

Identification of differentially expressed proteins from Burkholderia pseudomallei isolated during primary and relapsing melioidosis.

Influence of common non-synonymous Toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants.

Serum susceptibility in clinical isolates of Burkholderia cepacia complex bacteria: development of a growth-based assay for high throughput determination.

Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life.

Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life.

Recurrent subacute post-viral onset of ataxia associated with a PRF1 mutation.