Edit Y. Tshuva
Department of Chemistry,
Institute of Chemistry
The Hebrew University of Jerusalem
Edit Tshuva is a Full Professor of Chemistry at the Institute of Chemistry, the Faculty of Science, the Hebrew University of Jerusalem.
Born in 1975, Prof. Tshuva conducted her Ph.D. studies under the supervision of Prof. Moshe Kol at Tel-Aviv University. Throughout these studies, she developed early transition metal based catalysts for the stereoselective polymerization of terminal olefins. After graduating with Distinction in 2001, she continued to postdoctoral studies as a Fulbright fellow, and spent two years at The Massachusetts Institute of Technology (MIT), working under the supervision of Prof. Stephen J. Lippard on the development of synthetic models for metalloenzymes with that exhibit carboxylate-bridged di-iron sites.
In 2003 Prof. Tshuva joined the Hebrew University of Jerusalem as a Senior Lecturer holding the Allon fellowship, and was promoted to a Full Professor in 2016. Her research group is interested in various topics that relate to synthetic bioinorganic chemistry, applying coordination chemistry techniques in the synthesis and investigation of transition metal complexes that have valuable biological and medicinal applications. Among other topics, the Tshuva group has been working on the development and understanding of safe, potent, and targeted metal-based chemotherapy and peptide-based therapy for copper related disorders.
Prof. Tshuva was awarded several European Research Council (ERC) grants including StG, CoG, and PoC, and she has served in the editorial boards of ChemMedChem, JoVE, and Scientific Reports.
Photograph by: Ben Kelmer
Catalytic oxidation by a carboxylate-bridged non-heme diiron complex.
Journal of the American Chemical Society Mar, 2002 | Pubmed ID: 11890772
Synthetic models for non-heme carboxylate-bridged diiron metalloproteins: strategies and tactics.
Chemical reviews Feb, 2004 | Pubmed ID: 14871147
Catalytic oxidative ring opening of THF promoted by a carboxylate-bridged diiron complex, triarylphosphines, and dioxygen.
Inorganic chemistry Jul, 2004 | Pubmed ID: 15236556
Distinctive structural features of hydroxyamino-1,3,5-triazine ligands leading to enhanced hydrolytic stability of their titanium complexes.
Dalton transactions (Cambridge, England : 2003) Sep, 2006 | Pubmed ID: 16924295
Antitumor reactivity of non-metallocene titanium complexes of oxygen-based ligands: is ligand lability essential?
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry Aug, 2007 | Pubmed ID: 17483967
Active cytotoxic reagents based on non-metallocene non-diketonato well-defined C2-symmetrical titanium complexes of tetradentate bis(phenolato) ligands.
Journal of the American Chemical Society Oct, 2007 | Pubmed ID: 17877357
Synthesis and conformational analysis of constrained ethylene-bridged bis(hydroxylamino-1,3,5-triazine) compounds as tetradentate ligands; structure of rigid dinuclear Ti(IV) complex.
The Journal of organic chemistry Aug, 2008 | Pubmed ID: 18572965
Synthesis, characterization, cytotoxicity, and hydrolytic behavior of C2- and C1-symmetrical Ti(IV) complexes of tetradentate diamine bis(phenolato) ligands: a new class of antitumor agents.
Chemistry (Weinheim an der Bergstrasse, Germany) , 2009 | Pubmed ID: 19156656
Markedly different cytotoxicity of the two enantiomers of C(2)-symmetrical Ti(IV) phenolato complexes; mechanistic implications.
Dalton transactions (Cambridge, England : 2003) Feb, 2010 | Pubmed ID: 20104339
Different ortho and para electronic effects on hydrolysis and cytotoxicity of diamino bis(phenolato) "salan" Ti(IV) complexes.
Inorganic chemistry Feb, 2011 | Pubmed ID: 21214265
NMR characterization of a Cu(I)-bound peptide model of copper metallochaperones: insights on the role of methionine.
Chemical communications (Cambridge, England) Jun, 2011 | Pubmed ID: 21552638
The MXCXXC class of metallochaperone proteins: model studies.
Chemical Society reviews Nov, 2011 | Pubmed ID: 21695339
Trans titanium(IV) complexes of salen ligands exhibit high antitumor activity.
Inorganic chemistry Sep, 2011 | Pubmed ID: 21797239
Major impact of N-methylation on cytotoxicity and hydrolysis of salan Ti(IV) complexes: sterics and electronics are intertwined.
Dalton transactions (Cambridge, England : 2003) Oct, 2011 | Pubmed ID: 21874187
New insights on the active species and mechanism of cytotoxicity of salan-Ti(IV) complexes: a stereochemical study.
Inorganic chemistry Oct, 2011 | Pubmed ID: 21923127
A marked synergistic effect in antitumor activity of salan titanium(IV) complexes bearing two differently substituted aromatic rings.
Journal of the American Chemical Society Oct, 2011 | Pubmed ID: 21967133
Unexpected influence of stereochemistry on the cytotoxicity of highly efficient Ti(IV) salan complexes: new mechanistic insights.
Chemistry (Weinheim an der Bergstrasse, Germany) Dec, 2011 | Pubmed ID: 22076809
Cytotoxicity and hydrolysis of trans-Ti(IV) complexes of salen ligands: structure-activity relationship studies.
Inorganic chemistry Feb, 2012 | Pubmed ID: 22220885
Cytotoxic salan-titanium(IV) complexes: high activity toward a range of sensitive and drug-resistant cell lines, and mechanistic insights.
ChemMedChem Apr, 2012 | Pubmed ID: 22262543
Highly cytotoxic vanadium(V) complexes of salan ligands; insights on the role of hydrolysis.
Dalton transactions (Cambridge, England : 2003) May, 2012 | Pubmed ID: 22415291
High antitumor activity of highly resistant salan-titanium(IV) complexes in nanoparticles: an identified active species.
Angewandte Chemie (International ed. in English) Oct, 2012 | Pubmed ID: 22961758
Peptide models of Cu(I) and Zn(II) metallochaperones: the effect of pH on coordination and mechanistic implications.
Inorganic chemistry Mar, 2013 | Pubmed ID: 23458158
A comparative chemical-biological evaluation of titanium(IV) complexes with a salan or cyclopentadienyl ligand.
Chemical communications (Cambridge, England) May, 2013 | Pubmed ID: 23598498
Heteroleptic titanium(iv) catecholato/piperazine systems and their anti-cancer properties.
Dalton transactions (Cambridge, England : 2003) Nov, 2013 | Pubmed ID: 24201896
C1-symmetrical titanium(IV) complexes of salan ligands with differently substituted aromatic rings: enhanced cytotoxic activity.
Inorganic chemistry Mar, 2014 | Pubmed ID: 24588655
Anti-proliferative activity of nano-formulated phenolato titanium(IV) complexes against cancer cells.
ChemMedChem Jun, 2014 | Pubmed ID: 24677761
Highly Stable Tetra-Phenolato Titanium(IV) Agent Formulated into Nanoparticles Demonstrates Anti-Tumoral Activity and Selectivity.
Molecules (Basel, Switzerland) Oct, 2015 | Pubmed ID: 26473816
Highly Effective and Hydrolytically Stable Vanadium(V) Amino Phenolato Antitumor Agents.
Inorganic chemistry Jan, 2016 | Pubmed ID: 26699515
Unbound position II in MXCXXC metallochaperone model peptides impacts metal binding mode and reactivity: Distinct similarities to whole proteins.
Journal of inorganic biochemistry 06, 2016 | Pubmed ID: 26901629
Insights into molecular mechanism of action of salan titanium(IV) complex with in vitro and in vivo anticancer activity.
Journal of inorganic biochemistry 10, 2016 | Pubmed ID: 27090292
Effective Inhibition of Cellular ROS Production by MXCXXC-Type Peptides: Potential Therapeutic Applications in Copper-Homeostasis Disorders.
Chemistry (Weinheim an der Bergstrasse, Germany) Jun, 2016 | Pubmed ID: 27124086
Specific Design of Titanium(IV) Phenolato Chelates Yields Stable and Accessible, Effective and Selective Anticancer Agents.
Chemistry (Weinheim an der Bergstrasse, Germany) Jul, 2016 | Pubmed ID: 27320784
Selenocysteine containing analogues of Atx1-based peptides protect cells from copper ion toxicity.
Organic & biomolecular chemistry Aug, 2016 | Pubmed ID: 27349676
Fluorescent antitumor titanium(iv) salen complexes for cell imaging.
Dalton transactions (Cambridge, England : 2003) Mar, 2018 | Pubmed ID: 29451281
Synthesis of Pure Enantiomers of Titanium(IV) Complexes with Chiral Diaminobis(phenolato) Ligands and Their Biological Reactivity.
Scientific reports Jun, 2018 | Pubmed ID: 29946136
combinations of inert phenolato Ti(iv) complexes with clinically employed anticancer chemotherapy: synergy with oxaliplatin on colon cells.
RSC advances Feb, 2018 | Pubmed ID: 30009018
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