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Department of Biology
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Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2003 | Pubmed ID: 12909716
GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2005 | Pubmed ID: 15788781
Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2008 | Pubmed ID: 18768695
Intrabody gene therapy ameliorates motor, cognitive, and neuropathological symptoms in multiple mouse models of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2009 | Pubmed ID: 19864571
Antibody therapy in neurodegenerative disease.
Reviews in the neurosciences , 2010 | Pubmed ID: 21086760
Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1.
PloS one , 2011 | Pubmed ID: 21304966
Gene therapy in mouse models of huntington disease.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry Apr, 2011 | Pubmed ID: 21489966
Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease.
Molecular neurodegeneration , 2011 | Pubmed ID: 21854568
Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin.
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2011 | Pubmed ID: 21971427
Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice.
Human molecular genetics Feb, 2012 | Pubmed ID: 22328089
California Institute of Technology
Tinh N. Luong*,1,
Holly J. Carlisle*,1,
Amber Southwell1,
Paul H. Patterson1
1Department of Biology, California Institute of Technology
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