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Department of Chemical and Systems Biology
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Medulloblastoma growth inhibition by hedgehog pathway blockade.
Science (New York, N.Y.) Aug, 2002 | Pubmed ID: 12202832
Small molecule modulation of Smoothened activity.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2002 | Pubmed ID: 12391318
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
Genes & development Nov, 2002 | Pubmed ID: 12414725
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.
Science (New York, N.Y.) Dec, 2004 | Pubmed ID: 15618519
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
Nature chemical biology Jan, 2006 | Pubmed ID: 16408088
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.
Molecular and cellular biology Oct, 2006 | Pubmed ID: 16908539
Small-molecule regulation of zebrafish gene expression.
Nature chemical biology Mar, 2007 | Pubmed ID: 17237798
Light-controlled gene silencing in zebrafish embryos.
Nature chemical biology Oct, 2007 | Pubmed ID: 17717538
Gene regulation technologies in zebrafish.
Molecular bioSystems Apr, 2008 | Pubmed ID: 18354783
Fish 'n clicks.
Nature chemical biology Jul, 2008 | Pubmed ID: 18560429
Chemical technologies for probing embryonic development.
Chemical Society reviews Jul, 2008 | Pubmed ID: 18568156
The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning.
Developmental biology Sep, 2008 | Pubmed ID: 18590719
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Nature chemical biology Mar, 2009 | Pubmed ID: 19151731
The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling.
Angewandte Chemie (International ed. in English) , 2009 | Pubmed ID: 19222062
Converse conformational control of smoothened activity by structurally related small molecules.
The Journal of biological chemistry Jul, 2009 | Pubmed ID: 19366682
Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent.
Developmental biology Apr, 2009 | Pubmed ID: 19389352
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2009 | Pubmed ID: 19666565
Versatile synthesis and rational design of caged morpholinos.
Journal of the American Chemical Society Sep, 2009 | Pubmed ID: 19708646
Controlling destiny through chemistry: small-molecule regulators of cell fate.
ACS chemical biology Jan, 2010 | Pubmed ID: 20000447
Oligonucleotide-based tools for studying zebrafish development.
Zebrafish Mar, 2010 | Pubmed ID: 20392138
Synthetic strategies for studying embryonic development.
Chemistry & biology Jun, 2010 | Pubmed ID: 20609409
Targeted and Conditional Gene Expression Workshop, 8th International Conference on Zebrafish Development and Genetics.
Zebrafish Oct, 2008 | Pubmed ID: 20798783
Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways.
Chemical Society reviews Aug, 2011 | Pubmed ID: 21505654
Spatiotemporal control of embryonic gene expression using caged morpholinos.
Methods in cell biology , 2011 | Pubmed ID: 21924162
A crucial requirement for Hedgehog signaling in small cell lung cancer.
Nature medicine , 2011 | Pubmed ID: 21983857
A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury.
Science translational medicine Oct, 2011 | Pubmed ID: 22013124
Neuropilins are positive regulators of Hedgehog signal transduction.
Genes & development Nov, 2011 | Pubmed ID: 22051878
Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish.
Development (Cambridge, England) Dec, 2011 | Pubmed ID: 22069185
Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons.
Development (Cambridge, England) Dec, 2011 | Pubmed ID: 22069186
Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development.
Nature chemical biology , 2012 | Pubmed ID: 22286130
Stanford University
Joshua A. Clanton1,
Ilya A. Shestopalov2,
James K. Chen2,
Joshua T. Gamse1
1Department of Biological Sciences, Vanderbilt University,
2Department of Chemical and Systems Biology, Stanford University
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