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Institute of Reconstructive Neurobiology
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Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons.
Stem cells (Dayton, Ohio) Jul, 2008 | Pubmed ID: 18420830
A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2009 | Pubmed ID: 19218428
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.
Nature Nov, 2011 | Pubmed ID: 22113611
Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons.
PloS one , 2012 | Pubmed ID: 22272239
Small molecules enable highly efficient neuronal conversion of human fibroblasts.
Nature methods Jun, 2012 | Pubmed ID: 22484851
Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation.
The American journal of pathology Jun, 2012 | Pubmed ID: 22510327
Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies.
Nature reviews. Molecular cell biology Apr, 2013 | Pubmed ID: 23486282
Embryonic stem cell-based modeling of tau pathology in human neurons.
The American journal of pathology May, 2013 | Pubmed ID: 23499461
Nature reviews. Molecular cell biology Apr, 2013 | Pubmed ID: 23847783
Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration.
Nature neuroscience Jan, 2014 | Pubmed ID: 24241396
APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation.
Stem cell reports , 2013 | Pubmed ID: 24371804
Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy.
Molecular therapy : the journal of the American Society of Gene Therapy Sep, 2015 | Pubmed ID: 26061647
Modeling CNS Development and Disease.
Stem cells international , 2016 | Pubmed ID: 27642304
An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome.
Cell reports Apr, 2017 | Pubmed ID: 28380362
A Little Bit of Guidance: Mini Brains on Their Route to Adolescence.
Cell stem cell Aug, 2017 | Pubmed ID: 28777940
University of Bonn
Olivia Krefft*,1,
Ammar Jabali*,1,
Vira Iefremova1,
Philipp Koch1,2,3,
Julia Ladewig1
1Institute of Reconstructive Neurobiology, University of Bonn,
2Central Institute of Mental Health, University of Heidelberg/Medical Faculty Mannheim,
3, Hector Institute for Translational Brain Research (HITBR gGmbH)
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