Mitchell Kronenberg

Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines.

Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice.

Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides.

Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice.

The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex.

Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs.

The unconventional lifestyle of NKT cells.

CD1 tetramers: a powerful tool for the analysis of glycolipid-reactive T cells.

Homeostasis of V alpha 14i NKT cells.

Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer.

Peptide-independent folding and CD8 alpha alpha binding by the nonclassical class I molecule, thymic leukemia antigen.

Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice.

Human invariant V alpha 24-J alpha Q TCR supports the development of CD1d-dependent NK1.1+ and NK1.1- T cells in transgenic mice.

The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory.

Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity.

Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics.

CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells.

Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes.

NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells.

Intrathymic NKT cell development is blocked by the presence of alpha-galactosylceramide.

Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo.

Cross-presentation of disialoganglioside GD3 to natural killer T cells.

Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model.

An anti-inflammatory role for V alpha 14 NK T cells in Mycobacterium bovis bacillus Calmette-Guérin-infected mice.

CD4+ CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responses.

Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells.

Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function.

The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells.

Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus.

Natural killer T cells: natural or unnatural regulators of autoimmunity?

MHC-dependent and -independent modulation of endogenous Ly49 receptors on NK1.1+ T lymphocytes directed by T-cell receptor type.

Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity.

Presenting fats with SAPs.

Surface receptors identify mouse NK1.1+ T cell subsets distinguished by function and T cell receptor type.

Expansion of human Valpha24+ NKT cells by repeated stimulation with KRN7000.

NKT cells: what's in a name?

CD1d1 displayed on cell size beads identifies and enriches an NK cell population negatively regulated by CD1d1.

Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies.

The Third Way: Progress on pathways of antigen processing and presentation by CD1.

The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition.

Salmonella typhimurium infection halts development of type 1 diabetes in NOD mice.

Going both ways: immune regulation via CD1d-dependent NKT cells.

The role of innate immunity in autoimmunity.

ICOS costimulates invariant NKT cell activation.

Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells.

Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets.

IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2.

The mouse CD1d cytoplasmic tail mediates CD1d trafficking and antigen presentation by adaptor protein 3-dependent and -independent mechanisms.

Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule.

Toward an understanding of NKT cell biology: progress and paradoxes.

Cutting edge: IFN-gamma signaling to macrophages is required for optimal Valpha14i NK T/NK cell cross-talk.

Recognition of bacterial glycosphingolipids by natural killer T cells.

Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids.

CD1 and MHC II find different means to the same end.

A murine model of NKT cell-mediated liver injury induced by alpha-galactosylceramide/d-galactosamine.

Regulation of immunity by self-reactive T cells.

Mucosal T lymphocytes--peacekeepers and warriors.

Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis.

Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cells.

Infection, autoimmunity, and glycolipids: T cells detect microbes through self-recognition.

Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation.

Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells.

Phenotypical and functional alterations during the expansion phase of invariant Valpha14 natural killer T (Valpha14i NKT) cells in mice primed with alpha-galactosylceramide.

Activation or anergy: NKT cells are stunned by alpha-galactosylceramide.

Carboxylated glycans mediate colitis through activation of NF-kappa B.

The proatherogenic role of T cells requires cell division and is dependent on the stage of the disease.

Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH.

V alpha14 i NKT cells are innate lymphocytes that participate in the immune response to diverse microbes.

Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells.

Immediate antigen-specific effector functions by TCR-transgenic CD8+ NKT cells.

Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d.

CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma.

Elevated serum anti-I2 and anti-OmpW antibody levels in children with IBD.

A unique lymphotoxin {alpha}beta-dependent pathway regulates thymic emigration of V{alpha}14 invariant natural killer T cells.

The complementarity determining region 2 of BV8S2 (V beta 8.2) contributes to antigen recognition by rat invariant NKT cell TCR.

Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice.

Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.

Synergistic costimulation by both B7 molecules regulates colitis pathogenesis.

Activation of natural killer T cells by glycolipids.

Frontline T cells: gammadelta T cells and intraepithelial lymphocytes.

Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs.

On the road: progress in finding the unique pathway of invariant NKT cell differentiation.

Invariant NKT cells amplify the innate immune response to lipopolysaccharide.

Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses.

Natural killer T cells: know thyself.

Paradoxical effect of reduced costimulation in T cell-mediated colitis.

The unique role of natural killer T cells in the response to microorganisms.

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.

Invariant natural killer cells in the response to bacteria: the advent of specific antigens.

Role of NKT cells in the digestive system. IV. The role of canonical natural killer T cells in mucosal immunity and inflammation.

CD1 mediated T cell recognition of glycolipids.

Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis.

Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids.

Villous B cells of the small intestine are specialized for invariant NK T cell dependence.

Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms.

A crucial role for HVEM and BTLA in preventing intestinal inflammation.

Acid test: lipid antigens get into the groove.

Natural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells.

RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis.

Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals.

Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses.

Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation.

NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi.

NKG2A inhibits invariant NKT cell activation in hepatic injury.

Detection of microbes by natural killer T cells.

Unconventional ligand activation of herpesvirus entry mediator signals cell survival.

Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naive T cells.

Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.

Synthesis and evaluation of 3''- and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000.

NKT cells turn ten.

Carbohydrate specificity of the recognition of diverse glycolipids by natural killer T cells.

Innate-like recognition of microbes by invariant natural killer T cells.

The roles of 3' and 4' hydroxy groups in alpha-galactosylceramide stimulation of invariant natural killer T cells.

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis.

Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.

Transcriptional regulator Id2 controls survival of hepatic NKT cells.

T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment.

Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells.

Commensal microbiota and CD8+ T cells shape the formation of invariant NKT cells.

Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells.

A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity.

Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.

Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model.

Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection.

Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency.

The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode.

Regulation of inflammation, autoimmunity, and infection immunity by HVEM-BTLA signaling.

Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids.

Hepatic stellate cells function as regulatory bystanders.

Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection.

Invariant NKT cells are required for airway inflammation induced by environmental antigens.

Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria.

Cooling the fires of inflammation.

Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule.

Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells.

Glycolipids that elicit IFN-γ-biased responses from natural killer T cells.

Making memory at birth: understanding the differentiation of natural killer T cells.