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Gynaecology Oncology Group,
School of Biomedical Sciences and Pharmacy,
Gynaecology Oncology Group, School of Biomedical Sciences and Pharmacy
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In vivo evidence of role of bone morphogenetic protein-4 in the mouse ovary.
Animal reproduction science Jul, 2008 | Pubmed ID: 17644284
Drosophila follicle cells: morphogenesis in an eggshell.
Seminars in cell & developmental biology Jun, 2008 | Pubmed ID: 18304845
The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2008 | Pubmed ID: 18375761
Constitutive activation of Beta-catenin in uterine stroma and smooth muscle leads to the development of mesenchymal tumors in mice.
Biology of reproduction Sep, 2009 | Pubmed ID: 19403928
Lin28 promotes transformation and is associated with advanced human malignancies.
Nature genetics Jul, 2009 | Pubmed ID: 19483683
Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis.
Biology of reproduction Feb, 2010 | Pubmed ID: 19794154
Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchyme.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2010 | Pubmed ID: 20805501
Stromal deletion of the APC tumor suppressor in mice triggers development of endometrial cancer.
Cancer research Mar, 2011 | Pubmed ID: 21363919
Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN.
PloS one , 2011 | Pubmed ID: 21695255
Dynamic expression of bone morphogenetic protein 4 in reproductive organs of female mice.
Reproduction (Cambridge, England) Oct, 2011 | Pubmed ID: 21810858
Adenomatous polyposis coli (APC) is essential for maintaining the integrity of the seminiferous epithelium.
Molecular endocrinology (Baltimore, Md.) Oct, 2011 | Pubmed ID: 21816903
Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility.
Endocrinology Jan, 2012 | Pubmed ID: 22128018
Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2012 | Pubmed ID: 22308459
Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis.
Human molecular genetics Oct, 2012 | Pubmed ID: 22791749
Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.
PLoS genetics , 2012 | Pubmed ID: 22916036
The Müllerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained β-catenin signaling.
Carcinogenesis Dec, 2012 | Pubmed ID: 22962306
PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression.
Carcinogenesis Apr, 2013 | Pubmed ID: 23276799
Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.
Carcinogenesis Mar, 2014 | Pubmed ID: 24170201
Epithelial Wnt/βcatenin signalling is essential for epididymal coiling.
Developmental biology Apr, 2016 | Pubmed ID: 26934381
Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium.
Oncotarget Apr, 2016 | Pubmed ID: 27036037
Germ cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development.
Scientific reports Jun, 2016 | Pubmed ID: 27265527
Ovarian hormones through Wnt signalling regulate the growth of human and mouse ovarian cancer initiating lesions.
Oncotarget Oct, 2016 | Pubmed ID: 27588493
Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice.
Oncotarget Dec, 2016 | Pubmed ID: 27980219
Germ cell-specific sustained activation of Wnt signalling perturbs spermatogenesis in aged mice, possibly through non-coding RNAs.
Oncotarget Dec, 2016 | Pubmed ID: 27992363
University of Newcastle
Manish Kumar1,
Pradeep Tanwar1
1Gynaecology Oncology Group, School of Biomedical Sciences and Pharmacy, University of Newcastle
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