Department of Medicine
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Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus.
Circulation research Mar, 2013 | Pubmed ID: 23334860
PGC1α-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension.
American journal of respiratory and critical care medicine Apr, 2013 | Pubmed ID: 23449689
The role of redox signaling in epigenetics and cardiovascular disease.
Antioxidants & redox signaling May, 2013 | Pubmed ID: 23480168
Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension.
Pulmonary circulation Jan, 2013 | Pubmed ID: 23662191
Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension.
Journal of molecular medicine (Berlin, Germany) Oct, 2013 | Pubmed ID: 23794090
Atrioventricular heart block and syncope coincident with diagnosis of systemic lupus erythematosus.
The Canadian journal of cardiology Oct, 2013 | Pubmed ID: 23916739
Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jan, 2014 | Pubmed ID: 24076965
SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress.
Molecular and cellular biology Mar, 2014 | Pubmed ID: 24344202
Relevant issues in the pathology and pathobiology of pulmonary hypertension.
Journal of the American College of Cardiology Dec, 2013 | Pubmed ID: 24355640
Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus.
Journal of molecular medicine (Berlin, Germany) Sep, 2014 | Pubmed ID: 24906456
The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure.
Circulation research Jun, 2014 | Pubmed ID: 24951766
Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension.
Circulation Jan, 2015 | Pubmed ID: 25361553
Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model.
Critical care medicine Feb, 2015 | Pubmed ID: 25599491
Mitochondrial dynamics in cardiovascular disease: fission and fusion foretell form and function.
Journal of molecular medicine (Berlin, Germany) Mar, 2015 | Pubmed ID: 25669447
Soluble guanylate cyclase: a new therapeutic target for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
Clinical pharmacology and therapeutics Jan, 2015 | Pubmed ID: 25670386
Mitochondrial dynamics in pulmonary arterial hypertension.
Journal of molecular medicine (Berlin, Germany) Mar, 2015 | Pubmed ID: 25672499
Right ventricular adaptation and failure in pulmonary arterial hypertension.
The Canadian journal of cardiology Apr, 2015 | Pubmed ID: 25840092
Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension.
Circulation May, 2015 | Pubmed ID: 25964279
A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus.
Pflugers Archiv : European journal of physiology Jan, 2016 | Pubmed ID: 26395471
Gone fission: an asymptomatic STAT2 mutation elongates mitochondria and causes human disease following viral infection.
Brain : a journal of neurology Oct, 2015 | Pubmed ID: 26408653
Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension.
American journal of respiratory and critical care medicine 08, 2016 | Pubmed ID: 26926454
Pulmonary hypertension begets pulmonary hypertension: mutually reinforcing roles for haemodynamics, inflammation, and cancer-like phenotypes.
Cardiovascular research 07, 2016 | Pubmed ID: 27216865
Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications.
Advances in experimental medicine and biology , 2016 | Pubmed ID: 27343087
Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine.
Chest Jan, 2017 | Pubmed ID: 27645688
MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype.
American journal of respiratory and critical care medicine Feb, 2017 | Pubmed ID: 27648837
The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease.
Clinical science (London, England : 1979) 11, 2016 | Pubmed ID: 27660309
Executive Summary of the American Heart Association and American Thoracic Society Joint Guidelines for Pediatric Pulmonary Hypertension.
American journal of respiratory and critical care medicine Oct, 2016 | Pubmed ID: 27689707
Pulmonary pulse wave transit time is associated with right ventricular-pulmonary artery coupling in pulmonary arterial hypertension.
Pulmonary circulation Dec, 2016 | Pubmed ID: 28090301
Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension.
Journal of molecular medicine (Berlin, Germany) Apr, 2017 | Pubmed ID: 28265681
Abnormal angiogenesis in blood outgrowth endothelial cells derived from von Willebrand disease patients.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Mar, 2017 | Pubmed ID: 28362648
Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension.
Journal of the American Heart Association May, 2017 | Pubmed ID: 28566298
Resistance over compliance describes right ventricular afterload better than resistance-compliance time: a friendly amendment.
Pulmonary circulation Mar, 2017 | Pubmed ID: 28680587
Interleukin-6 is independently associated with right ventricular function in pulmonary arterial hypertension.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Mar, 2018 | Pubmed ID: 28893516
Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension.
Hypertension (Dallas, Tex. : 1979) 01, 2018 | Pubmed ID: 29158355
Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension.
Circulation Dec, 2017 | Pubmed ID: 29255124
Disproportionate Right Ventricular Dysfunction and Poor Survival in Group 3 Pulmonary Hypertension.
American journal of respiratory and critical care medicine Jun, 2018 | Pubmed ID: 29360393
Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications.
Circulation Jul, 2018 | Pubmed ID: 29431643
Increasing Incidence and Prevalence of World Health Organization Groups 1 to 4 Pulmonary Hypertension: A Population-Based Cohort Study in Ontario, Canada.
Circulation. Cardiovascular quality and outcomes Feb, 2018 | Pubmed ID: 29444925
Pulmonary arterial hypertension: pathogenesis and clinical management.
BMJ (Clinical research ed.) 03, 2018 | Pubmed ID: 29540357
Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research.
Circulation research Mar, 2018 | Pubmed ID: 29599278
A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017.
American journal of physiology. Lung cellular and molecular physiology Oct, 2018 | Pubmed ID: 29877097
Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension.
Frontiers in physiology , 2018 | Pubmed ID: 30042687
A Step Closer to Understanding How Riociguat Results in Remodelling of the Right Ventricle in Chronic Thromboembolic Pulmonary Hypertension.
The Canadian journal of cardiology Sep, 2018 | Pubmed ID: 30170664
Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities.
International journal of molecular sciences Sep, 2018 | Pubmed ID: 30213070
Survival in pulmonary hypertension due to chronic lung disease: Influence of low diffusion capacity of the lungs for carbon monoxide.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Sep, 2018 | Pubmed ID: 30391191
Ping Yu Xiong*,1,2,
Shunsuke Baba*,3,4,
Naritomo Nishioka3,5,
Yoshitaka Fujimoto3,
Stephen L. Archer1,
Susumu Minamisawa1,4
1Department of Medicine, Queen's University,
2Department of Biomedical and Molecular Sciences, Queen's University,
3Department of Cell Physiology, The Jikei University School of Medicine,
4Department of Pediatrics, The Jikei University School of Medicine,
5Department of Cardiovascular Surgery, The Jikei University School of Medicine
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