Thorsten Hoppe

Think locally: control of ubiquitin-dependent protein degradation in neurons.

Life and destruction: ubiquitin-mediated proteolysis in aging and longevity.

A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans.

CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.

Analysis of ubiquitin-dependent proteolysis in Caenorhabditis elegans.

Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome.

The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans.

A novel interaction between aging and ER overload in a protein conformational dementia.

Create and preserve: proteostasis in development and aging is governed by Cdc48/p97/VCP.

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.

Hexosamine pathway metabolites enhance protein quality control and prolong life.

Ubiquitin sets the timer: impacts on aging and longevity.

Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system.

Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo.

Reversible 26S proteasome disassembly upon mitochondrial stress.

Limited proteolysis: DisRUPting proteasomal inhibition.

The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.

MicroRNAs meet calcium: joint venture in ER proteostasis.

Regulation of the DNA damage response by ubiquitin conjugation.

Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegans.

Double-edged alliance: mitochondrial surveillance by the UPS and autophagy.

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.

Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin.

It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin.

E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis.

Stefan Jentsch (1955-2016)-Maestro of the ubiquitin family.

The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover.

Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis.

Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD).

Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity.

CHIPped balance of proteostasis and longevity.

Stressed Out: Mitohormesis Is Crossing Borders.

Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis.

Ub and Down: Ubiquitin Exercise for the Elderly.

The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients.

ERADicate Tumor Progression with Metformin.

Hepatic ERAD takes control of the organism.

Western blot analysis of the autophagosomal membrane protein LGG-1/LC3 in Caenorhabditis elegans.

Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signaling.

The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy.

Latest advances in aging research and drug discovery.

The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.

Author Correction: The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients.

Regulation of E3 ubiquitin ligases by homotypic and heterotypic assembly.

Mitochondrial Quality Control Governed by Ubiquitin.

The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells.

Author Correction: Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling.

Organismal Protein Homeostasis Mechanisms.

CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage.

Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior.

Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores.

The price of longevity.

Build-UPS and break-downs: metabolism impacts on proteostasis and aging.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

Correction to: Build-UPS and break-downs: metabolism impacts on proteostasis and aging.