Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass GraftRishav Aggarwal 1, Annie Shao 1, Koray N. Potel 2, Laura Hocum Stone 1, Cory Swingen 1, Christin Wright 1, Edward O. McFalls 3, Tammy A. Butterick 4,5, Rosemary F. Kelly 1
1Department of Surgery, University of Minnesota, 2School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, 3Cardiology, Richmond VA Medical Center, 4Department of Research Service, Center for Veterans Research and Education, Veterans Affairs Health Care System, 5Department of Neuroscience, University of Minnesota
This study presents a surgical porcine model of chronic myocardial ischemia due to progressive coronary artery stenosis, resulting in impaired cardiac function without infarction. Following ischemia, animals undergo off-pump coronary artery bypass graft with epicardial placement of stem cells-derived exosomes-laden collagen patch. This adjunctive therapy improves myocardial function and recovery.
