Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse ModelSe-Eun Lee *1, Chiyeon Lim *2, Minji Lee 1, Chang-Hyun Kim 2, Hyungwoo Kim 1, Byoungho Lee 3, Suin Cho 1
1School of Korean Medicine, Pusan National University, 2College of Medicine, Dongguk University, 3Kyunghee Naseul Korean Medicine Clinic
In this study, we modify an existing experimental method to obtain more reproducible results, by establishing a middle cerebral artery occlusion (MCAO) mouse model. Oral administration of Glycyrrhizae Radix et Rhizome (GR) methanol extract (GRex), following stroke induction, significantly decreased total infarction volume relative to the untreated control group.
