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Kean University

3 ARTICLES PUBLISHED IN JoVE

Biology

Trajectory Data Analyses for Pedestrian Space-time Activity Study

¹School of Environmental and Life Sciences, Kean University, ²Department of Geography, University of Wisconsin-Madison

A suite of spatiotemporal processing methods are presented to analyze human trajectory data, such as that collected using a GPS device, for the purpose of modeling pedestrian space-time activities.

Immunology and Infection

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages

Farshad Tamari¹, Joanna Tychowski², Laura Lorentzen³

¹Department of Biological Sciences, Kingsborough Community College, ²Institute for Cellular and Molecular Biology, University of Texas at Austin, ³New Jersey Center for Science, Technology and Mathematics, Kean University

We set out to determine tolerable concentrations of three fatty acids (oleic, linoleic and linolenic acids) and cholera toxin that did not significantly and adversely affect cell survival by solubilizing the fatty acids and the toxin and using them in cell survival assays.

Cancer Research

Coculture Assays to Study Macrophage and Microglia Stimulation of Glioblastoma Invasion

Salvatore Coniglio¹, Ian Miller², Marc Symons³, Jeffrey E. Segall⁴

¹New Jersey Center for Science, Technology and Mathematics, Kean University, ²Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, ³The Feinstein Institute for Medical Research at North Shore-LIJ, ⁴Department of Anatomy and Structural Biology, Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine

Understanding the malignant behavior of cancer requires creating accurate models of how tumor cells interact with components of the tumor microenvironment, such as macrophages. Here we describe two methods to study glioblastoma cell interaction with tumor associated macrophages and microglia where the effect on glioblastoma invasion is assessed.