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Pusan National University

3 ARTICLES PUBLISHED IN JoVE

Chemistry

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Youngkyu Han¹, Suk-kyun Ahn^2,3, Zhe Zhang^1,4, Gregory S. Smith¹, Changwoo Do¹

¹Biology and Soft Matter Division, Neutron Science Directorate, Oak Ridge National Laboratory, ²Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, ³Department of Polymer Science and Engineering, Pusan National University, ⁴Jülich Center for Neutron Science, Forschungszentrum Jülich

A method for the functionalization of carbon nanotubes with structure-tunable polymeric encapsulation layers and structural characterization using small-angle neutron scattering is presented.

Medicine

Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model

Se-Eun Lee^*1, Chiyeon Lim^*2, Minji Lee¹, Chang-Hyun Kim², Hyungwoo Kim¹, Byoungho Lee³, Suin Cho¹

¹School of Korean Medicine, Pusan National University, ²College of Medicine, Dongguk University, ³Kyunghee Naseul Korean Medicine Clinic

In this study, we modify an existing experimental method to obtain more reproducible results, by establishing a middle cerebral artery occlusion (MCAO) mouse model. Oral administration of Glycyrrhizae Radix et Rhizome (GR) methanol extract (GRex), following stroke induction, significantly decreased total infarction volume relative to the untreated control group.

Behavior

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Hyeonwi Son¹, Ju Hwan Yang², Hyun Joon Kim^*1, Dong Kun Lee^*3

¹Department of Anatomy and Convergence Medical Sciences, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University Medical School, ²Department of Biological Sciences, Pusan National University, ³Department of Physiology and Convergence Medical Sciences, Institute of Health Sciences, Gyeongsang National University Medical School

This article provides a simplified and standardized protocol for induction of depressive-like behavior in chronically immobilized mice by using a restrainer. In addition, behavior and physiological techniques to verify induction of depression are explained.