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University Hospital Center and University of Lausanne

3 ARTICLES PUBLISHED IN JoVE

Medicine

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index

Marie Schaer¹, Meritxell Bach Cuadra^2,3, Nick Schmansky⁴, Bruce Fischl⁴, Jean-Philippe Thiran², Stephan Eliez¹

¹Department of Psychiatry, University of Geneva School of Medicine, ²Signal Processing Laboratory, École Polytechnique Fédérale de Lausanne, ³Department of Radiology, University Hospital Center and University of Lausanne, ⁴Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital

Measuring gyrification (cortical folding) at any age represents a window into early brain development. Hence, we previously developed an algorithm to measure local gyrification at thousands of points over the hemisphere¹. In this paper, we detail the computation of this local gyrification index.

Immunology and Infection

Discovery of New Intracellular Pathogens by Amoebal Coculture and Amoebal Enrichment Approaches

Nicolas Jacquier¹, Sébastien Aeby¹, Julia Lienard¹, Gilbert Greub¹

¹Institute of Microbiology, University Hospital Center and University of Lausanne

Amoebal coculture is a cell culture system using adherent amoebae to selectively grow intracellular pathogens able to resist phagocytic cells such as amoebae and macrophages. It thus represents a key tool to discover new infectious agents. Amoebal enrichment allows discovery of new amoebal species and of their specific intracellular bacteria.

Immunology and Infection

Preparation of a Blood Culture Pellet for Rapid Bacterial Identification and Antibiotic Susceptibility Testing

Antony Croxatto¹, Guy Prod'hom¹, Christian Durussel¹, Gilbert Greub¹

¹Institute of Microbiology, University Hospital Center and University of Lausanne

A rapid bacterial pellet preparation from a positive blood culture can be used as a sample for applications such as identification by MALDI-TOF, Gram staining, antibiotic susceptibility testing and PCR-based test. The results can be rapidly communicated to clinicians to improve the outcome of patients suffering from bloodstream infections.