Granulocyte-dependent Autoantibody-induced Skin BlisteringKinga Csorba 1, Sebastian Sitaru 2, Cassian Sitaru 1,3
1Department of Dermatology, University of Freiburg , 2Kepler High School Freiburg, 3Centre for Biological Signalling Studies (BIOSS), University of Freiburg
In the animal model described in our present work, purified IgG antibodies against a stretch of 200 amino acids (aa 757-967) of collagen VII are injected repeatedly into mice reproducing the blistering phenotype as well as the histo- and immunopathological features characteristic to human epidermolysis bullosa acquisita (EBA)1.
