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Université de Caen Basse-Normandie

2 ARTICLES PUBLISHED IN JoVE

Medicine

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Pei-Yi Lin¹, Nadege Roche-Labarbe^1,2, Mathieu Dehaes³, Stefan Carp¹, Angela Fenoglio³, Beniamino Barbieri⁴, Katherine Hagan¹, P. Ellen Grant³, Maria Angela Franceschini¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, ²Lab. PALM, Université de Caen Basse-Normandie, ³Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, ⁴ISS, INC.

We combined frequency-domain near-infrared spectroscopy measures of cerebral hemoglobin oxygenation with diffuse correlation spectroscopy measures of cerebral blood flow index to estimate an index of oxygen metabolism. We tested the utility of this measure as a bedside screening tool to evaluate the health and development of the newborn brain.

Medicine

A Sensitive Method to Quantify Senescent Cancer Cells

Julie Cahu¹, Brigitte Sola¹

¹MILPAT (EA 4652), Université de Caen Basse-Normandie

Whether senescence prevents or promotes tumorigenesis remains controversial. Since chemotherapeutical drugs can induce cancer cells to senesce, studying senescence is essential for proposing new therapies. However, the standard and broadly used β-galactosidase assay presents major drawbacks. We propose here a rapid and sensitive flow cytometry-based assay to quantify senescence.