Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft SurgeryLaura Hocum Stone 1, Christin Wright 1, Erin Chappuis 1, Mia Messer 1, Herbert B. Ward 1, Edward O. McFalls 2, Rosemary F. Kelly 1
1Department of Surgery, University of Minnesota, 2Cardiology, Minneapolis VA Medical Center
This protocol presents a surgical large animal model of chronic, single vessel ischemia that results in regional abnormalities but does not create infarct, known as hibernating myocardium. Following establishment of chronic ischemia, animals are treated with off-pump LIMA-LAD coronary artery bypass graft surgery to revascularize the ischemic tissue.
